Cited by 311Curcumin's Biomedical ApplicationsCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatments

Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer’s disease

Ahmed, Touqeer, Gilani, Anwarul-Hassan·2009·Pharmacology Biochemistry and Behavior

Abstract

Curcuminoids (a mixture of curcumin, bisdemethoxycurcumin and demethoxycurcumin) share vital pharmacological properties possessed by turmeric, a well known curry spice, considered useful in Alzheimer's disease (AD). The aim of this study was to evaluate if curcuminoids possess acetylcholinesterase (AChE) inhibitory and memory enhancing activities. The in-vitro and ex-vivo models of AChE inhibitory activity were used along with Morris water maze test to study the effect on memory in rats. Curcuminoids inhibited AChE in the in-vitro assay with IC(50) value of 19.67, bisdemethoxycurcumin 16.84, demethoxycurcumin 33.14 and curcumin 67.69 microM. In the ex-vivo AChE assay, curcuminoids and its individual components except curcumin showed dose-dependent (3-10 mg/kg) inhibition in frontal cortex and hippocampus. When studied for their effect on memory at a fixed dose (10 mg/kg), all compounds showed significant (p<0.001) and comparable effect in scopolamine-induced amnesia. These data indicate that curcuminoids and all individual components except curcumin possess pronounced AChE inhibitory activity. Curcumin was relatively weak in the in-vitro assay and without effect in the ex-vivo AChE model, while equally effective in memory enhancing effect, suggestive of additional mechanism(s) involved. Thus curcuminoids mixture might possess better therapeutic profile than curcumin for its medicinal use in AD.

Integrity signals

Registry

Crossref · 10.1016/j.pbb.2008.09.010

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 60 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Ahmed, T., & Gilani, A.-H.
Affiliations
Aga Khan University (PK)
Corresponding author
Gilani, Anwarul-Hassan
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2009-02
Volume
91
Issue
4
Pages
554-559
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2010499668
Cited by
301
References
60
Citations by year
2026: 6 · 2025: 13 · 2024: 16 · 2023: 17 · 2022: 17 · 2021: 18 · 2020: 28 · 2019: 28 · 2018: 14 · 2017: 21 · 2016: 19 · 2015: 14 · 2014: 20 · 2013: 22 · 2012: 19
FWCI
4.74
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • eCommons - AKU (Aga Khan University) (submittedVersion)
Funders
  • National Council for Higher Education
  • Yükseköğretim Kurulu
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
curcuminoids, curcumin, bisdemethoxycurcumin, demethoxycurcumin, acetylcholinesterase inhibition, scopolamine-induced amnesia, memory enhancement, Alzheimer's disease, turmeric, hippocampus, frontal cortex
MeSH terms
Acetylcholinesterase, Alzheimer Disease, Amnesia, Animals, Cholinesterase Inhibitors, Curcumin, Dose-Response Relationship, Drug, Hippocampus, Male, Phytotherapy, Memory, Parasympatholytics, Scopolamine, Rats, Sprague-Dawley, Prefrontal Cortex, Maze Learning, Curcuma, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review