Rate of Nonadherence to Antipsychotic Medications and Factors Leading to Nonadherence among Psychiatric Patients in Gondar University Hospital, Northwest Ethiopia
Open accessAbstract
Objective. The main aim of this study was to assess the rate of medication nonadherence among psychiatry patients at University of Gondar Hospital. Materials and Methods. Cross-sectional, descriptive method was conducted over a period of one month in May, 2013, at University of Gondar Hospital. Rate of nonadherence was computed using Medication Adherence Rating Scale questionnaire and self-reporting via a structured patient interview. Chi-square was used to determine the statistical significance of the association of variables with adherence. Result. Out of 209 respondents, 105 (50.2%) were found to be nonadherent. Patients who were forced to take their medication against their will (P<0.001), those who did not believe they require medication (P=0.026), and those who discontinued their medication without consulting their prescriber (P<0.001) had significant association with nonadherence. Adherence among schizophrenia was 75.7%; psychotic was 46.7%; bipolar disorder was 37.5%; and psychosis with depression was 52.6%. Reasons for nonadherence included recovery from the illness (26.7%), seeking alternative therapy and unavailability of drugs (18.1% each), adverse drug reaction (12.7%), forgetfulness (10.6%), and being busy (8.6%). Conclusion. The observed rate of antipsychotic medication nonadherence in this study was high. Interventions to increase adherence are therefore crucial.
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Patients and caregivers' perceived medication adverse drug reaction was a factor associated with psychotropic medication non-adherence in two studies.
“Moreover, patients and caregivers’ perceived medication adverse drug reaction was a factor associated with psychotropic medication non-adherence [34, 36].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [34]
Taking lower potent concomitant psychotropic medications, recovery from illness, felt better, and failure to improve with medication were factors associated with medication efficacy related with psychotropic medication non-adherence.
“Taking lower potent concomitant psychotropic medications [47, 65], recovery from illness [34], felt better [24, 52], and failure to improve with medication [37] were the factors associated with medication efficacy related with psychotropic medication non-adherence.”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [34]
Medication non-adherence was associated with lack of free access to medicine due to inadequate or unavailability of psychotropic drug supplies in health facilities in three studies.
“In three studies, medication non-adherence was associated with lack of free access to medicine due to inadequate or unavailability of psychotropic drug supplies in health facilities [24, 25, 34].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [34]
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Cites
Osterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974 · see citing works
Patient adherence to treatment: three decades of research. A comprehensive review
Vermeire, E., Hearnshaw, H., Royen, P. V., & Denekens, J. (2001) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2001.00363.x · Cited by 1,833 · see citing works
Robinson, D., Woerner, M. G., Alvir, J. M. J., Bilder, R., Goldman, R., Geisler, S., Koreen, A., Sheitman, B., Chakos, M., Mayerhoff, D., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.3.241 · Cited by 1,327 · see citing works
Reliability and validity of a new Medication Adherence Rating Scale (MARS) for the psychoses
Thompson, K. N., Kulkarni, J., & Sergejew, A. A. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00130-9 · Cited by 997 · see citing works
Determinants of Medication Compliance in Schizophrenia: Empirical and Clinical Findings
Fenton, W. S., Blyler, C. R., & HEINSSEN, R. K. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.4.637 · Cited by 944 · see citing works
Compliance With Medication Regimens for Mental and Physical Disorders
Cramer, J. A., & Rosenheck, R. (1998) · Psychiatric Services · doi:10.1176/ps.49.2.196 · Cited by 725 · see citing works
Velligan, D. I., Weiden, P. J., Sajatovic, M., Scott, J. L., Carpenter, D., Ross, R., & Docherty, J. P. (2009) · PubMed · Cited by 625 · see citing works
Antipsychotic Medication Adherence: Is There a Difference Between Typical and Atypical Agents?
Dolder, C. R., Lacro, J. P., Dunn, L. B., & Jeste, D. V. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.1.103 · Cited by 385 · see citing works
Morken, G., Widen, J. H., & Gråwe, R. W. (2008) · BMC Psychiatry · doi:10.1186/1471-244x-8-32 · Cited by 299 · see citing works
Predicting medication adherence in severe mental disorders
Adams, J. M., & Scott, J. L. (2000) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2000.90061.x · Cited by 208 · see citing works
Alcoholism treatment adherence: older age predicts better adherence and drinking outcomes.
Oslin, D., Pettinati, H., & Volpicelli, J. (2002) · The American journal of geriatric psychiatry · doi:10.1097/00019442-200211000-00013 · Cited by 150 · see citing works
The Effects of Monitoring and Feedback on Compliance
Elixhauser, A., Eisen, S. A., Romeis, J. C., & Homan, S. M. (1990) · Medical Care · doi:10.1097/00005650-199010000-00003 · Cited by 61 · see citing works
Factors Associated with Medication Adherence Among Psychiatric Outpatients at Substance Abuse Risk
Magura, S. (2011) · The Open Addiction Journal · doi:10.2174/1874941001104010058 · Cited by 59 · see citing works
Taj, F., Tanwir, M., Aly, Z., Khowajah, A. A., Tariq, A., Syed, F. K., Waqar, F., & Shahzada, K. (2008) · PubMed · Cited by 51 · see citing works
A study of reasons of non-compliance to psychiatric treatment.
Taj, R., & Khan, S. (2005) · PubMed · Cited by 40 · see citing works
Alene, M., Wiese, M. D., Angamo, M. T., Bajorek, B. V., Yesuf, E. A., & Wabe, N. T. (2012) · BMC Clinical Pharmacology · doi:10.1186/1472-6904-12-10 · Cited by 34 · see citing works
Medication adherence of psychiatric patients in an outpatient setting
Mahaye, S. (2012) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp11.646 · Cited by 31 · see citing works
The Noncompliant Patient in Psychiatry: The Case For and Against Covert/Surreptitious Medication
Latha, K. (2010) · Mens Sana monographs · doi:10.4103/0973-1229.58822 · Cited by 29 · see citing works
Alcoholism Treatment Adherence: Older Age Predicts Better Adherence and Drinking Outcomes
Oslin, D. (2002) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.10.6.740 · Cited by 22 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- H. Thomas and E. Donald, "Primary medication adherence in rural population, " The Journal of American Family Medicine, vol. 12, pp. 27-59, 2006.
Cited by
Sorted by citations
Semahegn, A., Torpey, K., Manu, A., Assefa, N., Tesfaye, G., & Ankomah, A. (2020) · Systematic Reviews · doi:10.1186/s13643-020-1274-3 · Cited by 555 · see citing works
Zortéa, K., Franco, V. C., Guimarães, P., & Belmonte-de-Abreu, P. S. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00159 · Cited by 56 · see citing works
Zortéa, K., Franco, V. C., Francesconi, L. P., Ceresér, K. M. M., Lobato, M. I. R., & Belmonte-de-Abreu, P. S. (2016) · Nutrients · doi:10.3390/nu8020073 · Cited by 56 · see citing works
Demeke, S. M., Mossie, T. B., Mekonen, T., & Menberu, M. (2021) · International Journal of Mental Health Systems · doi:10.1186/s13033-021-00464-0 · Cited by 51 · see citing works
Khalifeh, A. H., & Hamdan‐Mansour, A. M. (2020) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/02793695-20201015-05 · Cited by 22 · see citing works
Gudeta, D. B., Leta, K., Alemu, B., & Kandula, U. R. (2023) · PLoS ONE · doi:10.1371/journal.pone.0283829 · Cited by 21 · see citing works
Inwanna, S., Duangchan, C., & Matthews, A. K. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19052887 · Cited by 19 · see citing works
Zewdu, W. S., Dagnew, S. B., Tarekegn, G. Y., Yazie, T. S., Ayicheh, M. A., Dagnew, F. N., & Moges, T. A. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06838-9 · Cited by 18 · see citing works
Ashong, S., Kretchy, I. A., Afrane, B. A., & Aikins, A. D. (2018) · Psychiatry Journal · doi:10.1155/2018/9850594 · Cited by 12 · see citing works
Tamene, F. B., Mihiretie, E. A., Mulugeta, A., Kassaye, A., Gubae, K., & Wondm, S. A. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06004-7 · Cited by 11 · see citing works
Tamene, F. B., Sema, F. D., Mihiretie, E. A., Solomon, T., & Sendekie, A. K. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-074112 · Cited by 7 · see citing works
Kretchy, I. A., Appiah, B., Agyabeng, K., Kwarteng, E. B., Ganyaglo, E., & Aboagye, G. O. (2021) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-021-01264-9 · Cited by 7 · see citing works
Tsega, S. S., Wassie, Y. A., Zegeye, A. F., Kiflu, M., Wubante, S. M., Mekonnen, K., Yazew, B. G., Mekonnen, B. D., & Tarekegn, Y. A. (2025) · BMC Research Notes · doi:10.1186/s13104-025-07080-y · Cited by 6 · see citing works
Landmarks of pharmacogenomics and some considerations for clinical practice
Ampong, D. N. (2019) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125319896650 · Cited by 4 · see citing works
Gebru, W. A., Kidanemariam, G., Berhe, K. T., Begashaw, T. D., Reta, H. G., & Gebreslassie, H. T. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07202-7 · Cited by 3 · see citing works
Adherence to Pharmacological Treatment Among Patients with Schizophrenia
Abdulkareem, M., & Mahmood, H. (2022) · Iraqi National Journal of Medicine · doi:10.37319/iqnjm.4.1.4 · Cited by 3 · see citing works
Beyene, M. G., Teferra, S., & Fenta, T. G. (2025) · PLoS ONE · doi:10.1371/journal.pone.0314403 · Cited by 2 · see citing works
Tamene, F. B., Mihiretie, E. A., Zeleke, T. K., Sendekie, A. K., Belachew, E. A., & Wondm, S. A. (2025) · Scientific Reports · doi:10.1038/s41598-025-85379-3 · Cited by 4 · see citing works
Amatayakul, A., Purnama, H., & Maneerat, S. (2016) · International Conference on Advances in Economics, Social Science and Human Behaviour Study (ESSHBS) · doi:10.15224/978-1-63248-098-9-33 · Cited by 2 · see citing works
Effects of missed dose and delayed dose quetiapine on its pharmacokinetics and pharmacodynamics
Methaneethorn, J. (2022) · Therapies · doi:10.1016/j.therap.2022.08.001 · Cited by 1 · see citing works
Drug therapy problems in patients with schizophrenia: A cross-sectional study
Temtem, G., Woldu, M. A., Berha, A. B., Shibeshi, W., Teferra, S., & Engidawork, E. (2023) · Clinical Medicine Insights Psychiatry · doi:10.1177/11795573231222147 · Cited by 1 · see citing works
Delcine, J. M., Shivanand, H. B., Mangalwedhe, S. B., Arunkumar, C., Anusha, M. S., & Desai, M. (2023) · Taiwanese Journal of Psychiatry · doi:10.4103/tpsy.tpsy_32_23 · Cited by 1 · see citing works
Duman, Z. Ç., Ertem, M., Yakışır, A., & Işıklı, S. (2025) · Journal of Health Psychology · doi:10.1177/13591053251384826 · Cited by 1 · see citing works
Nalini, S. (2020) · Indian Journal of Public Health Research & Development · doi:10.37506/ijphrd.v11i11.11371 · Cited by 1 · see citing works
Sarwar, A. S., Khan, A., Mehmood, T., Khan, J., Malik, O., & Johar, M. (2020) · American Scientific Research Journal for Engineering, Technology, and Sciences
Psychoeducation in Bipolar Disorder
Huang, J. J. S., Khoe, H. C. H., & Ho, C. S. H. (2025) · Springer eBooks · doi:10.1007/978-3-031-85519-1_29
Medication Non‐Adherence in First Episode Psychosis: A Systematic Review
Hunt, J., & Georgiades, A. (2026) · Early Intervention in Psychiatry · doi:10.1111/eip.70234
- Authors
- Endale Gurmu, A., Abdela, E., Allele, B., Cheru, E., & Amogne, B.
- Affiliations
- School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia
- University of Gondar (ET)
- ORCID
- Endale Gurmu, Abyot
- Venue
- Advances in Psychiatry
- Publisher
- Wiley
- Published
- 2014-12-16
- Volume
- 2014
- Pages
- 1-5
- ISSN
- 2314-7768 (ISSN-L)
- 2356-685X
- OpenAlex
- W1983887793
- Cited by
- 28
- References
- 18
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 1 · 2016: 3
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Advances in Psychiatry (publishedVersion, cc-by)
- Funders
- University of Gondar
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- medication non-adherence, antipsychotic drugs, psychiatric patients, schizophrenia, bipolar disorder, reasons for non-adherence, adverse drug reactions, drug availability, adherence interventions
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