The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Tumor Suppression and Promotion by Autophagy
Open accessAbstract
Autophagy is a highly regulated catabolic process that involves lysosomal degradation of proteins and organelles, mostly mitochondria, for the maintenance of cellular homeostasis and reduction of metabolic stress. Problems in the execution of this process are linked to different pathological conditions, such as neurodegeneration, aging, and cancer. Many of the proteins that regulate autophagy are either oncogenes or tumor suppressor proteins. Specifically, tumor suppressor genes that negatively regulate mTOR, such as PTEN, AMPK, LKB1, and TSC1/2 stimulate autophagy while, conversely, oncogenes that activate mTOR, such as class I PI3K, Ras, Rheb, and AKT, inhibit autophagy, suggesting that autophagy is a tumor suppressor mechanism. Consistent with this hypothesis, the inhibition of autophagy promotes oxidative stress, genomic instability, and tumorigenesis. Nevertheless, autophagy also functions as a cytoprotective mechanism under stress conditions, including hypoxia and nutrient starvation, that promotes tumor growth and resistance to chemotherapy in established tumors. Here, in this brief review, we will focus the discussion on this ambiguous role of autophagy in the development and progression of cancer.
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Cites
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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mTOR: from growth signal integration to cancer, diabetes and ageing
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Autophagy and the Integrated Stress Response
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Cited by
The Roles of Autophagy in Cancer
Yun, C. W., & Lee, S. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113466 · Cited by 965
Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy
Poillet-Perez, L., Despouy, G., Delage-Mourroux, R., & Boyer-Guittaut, M. (2015) · Redox Biology · doi:10.1016/j.redox.2014.12.003 · Cited by 503
The interplay of ROS and the PI3K/Akt pathway in autophagy regulation
Kma, L., & Baruah, T. J. (2022) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2104 · Cited by 394
Mitochondria‐associated endoplasmic reticulum membrane: Overview and inextricable link with cancer
Yang, X., Zhuang, J., Song, W., Shen, W., Wu, W., Shen, H., & Han, S. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17696 · Cited by 55
Autophagy dark genes: Can we find them with machine learning?
Ranjbar, M., Yang, J. J., Kumar, P., Byrd, D. R., Bearer, E. L., & Oprea, T. I. (2023) · Natural Sciences · doi:10.1002/ntls.20220067 · Cited by 7
Metadata
- Authors
- Ávalos, Y., Canales, J., Bravo-Sagua, R., Criollo, A., Lavandero, S., & Quest, A. F. G.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-15
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W1991903498
- Cited by
- 196
- References
- 31
- FWCI
- 12.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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