Taurine Rescues Cisplatin-Induced Muscle Atrophy in Vitro: A Morphological Study
Open accessAbstract
Cisplatin (CisPt) is a widely used chemotherapeutic drug whose side effects include muscle weakness and cachexia. Here we analysed CisPt-induced atrophy in C2C12 myotubes by a multidisciplinary morphological approach, focusing on the onset and progression of autophagy, a protective cellular process that, when excessively activated, may trigger protein hypercatabolism and atrophy in skeletal muscle. To visualize autophagy we used confocal and transmission electron microscopy at different times of treatment and doses of CisPt. Moreover we evaluated the effects of taurine, a cytoprotective beta-amino acid able to counteract oxidative stress, apoptosis, and endoplasmic reticulum stress in different tissues and organs. Our microscopic results indicate that autophagy occurs very early in 50 μM CisPt challenged myotubes (4 h-8 h) before overt atrophy but it persists even at 24 h, when several autophagic vesicles, damaged mitochondria, and sarcoplasmic blebbings engulf the sarcoplasm. Differently, 25 mM taurine pretreatment rescues the majority of myotubes size upon 50 μM CisPt at 24 h. Taurine appears to counteract atrophy by restoring regular microtubular apparatus and mitochondria and reducing the overload and the localization of autophagolysosomes. Such a promising taurine action in preventing atrophy needs further molecular and biochemical studies to best define its impact on muscle homeostasis and the maintenance of an adequate skeletal mass in vivo.
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In C2C12 myotubes, taurine rescues cisplatin-induced muscle atrophy by restoring microtubular and mitochondrial function and reducing overload and localization of autophagolysosomes.
“In C2C12 myotubes, Stacchiotti et al. reported that taurine rescues cisplatin-induced muscle atrophy by restoring microtubular and mitochondrial function and reducing the overload and the localization of autophagolysosomes [38].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [38]
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- Authors
- Stacchiotti, A., Rovetta, F., Ferroni, M., Corsetti, G., Lavazza, A., Sberveglieri, G., & Aleo, M. F.
- Affiliations
- University of Brescia (IT)
- Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini" (IT)
- Corresponding author
- Stacchiotti, Alessandra
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Hindawi Limited
- Published
- 2014
- Volume
- 2014
- Pages
- 1-11
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC4053152
- OpenAlex
- W2121035565
- Cited by
- 21
- References
- 55
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2013: 1
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
- Keywords
- taurine, cisplatin, muscle atrophy, autophagy, skeletal muscle, C2C12 myotubes, chemotherapy-induced myopathy, autophagolysosomes, mitochondria, oxidative stress, cachexia
- MeSH terms
- Adenine, Animals, Autophagy, Cell Line, Cisplatin, Muscular Atrophy, Necrosis, Taurine, Time Factors, Tubulin, Apoptosis, Muscle Fibers, Skeletal, Mice
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