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Cited by 28Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationNeonatal Respiratory Health Research

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Hematopoietic and Mesenchymal Stem Cells for the Treatment of Chronic Respiratory Diseases: Role of Plasticity and Heterogeneity

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Conese, Massimo, Piro, Donatella, Carbone, Annalucia, Castellani, Stefano, Di Gioia, Sante·2014·The Scientific World Journal
DOI 10.1155/2014/859817PMC PMC3916026
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Abstract

Chronic lung diseases, such as cystic fibrosis (CF), asthma, and chronic obstructive pulmonary disease (COPD) are incurable and represent a very high social burden. Stem cell-based treatment may represent a hope for the cure of these diseases. In this paper, we revise the overall knowledge about the plasticity and engraftment of exogenous marrow-derived stem cells into the lung, as well as their usefulness in lung repair and therapy of chronic lung diseases. The lung is easily accessible and the pathophysiology of these diseases is characterized by injury, inflammation, and eventually by remodeling of the airways. Bone marrow-derived stem cells, including hematopoietic stem/progenitor cells (HSPCs) and mesenchymal stromal (stem) cells (MSCs), encompass a wide array of cell subsets with different capacities of engraftment and injured tissue regenerating potential. Proof-of-principle that marrow cells administered locally may engraft and give rise to specialized epithelial cells has been given, but the efficiency of this conversion is too limited to give a therapeutic effect. Besides the identification of plasticity mechanisms, the characterization/isolation of the stem cell subpopulations represents a major challenge to improving the efficacy of transplantation protocols used in regenerative medicine for lung diseases.

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Figure 1 Still debated issues about homing and engraftment of marrow cells in the lung.
Figure 1 Still debated issues about homing and engraftment of marrow cells in the lung.CC BY · PubMed Central

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Metadata

Authors
Conese, M., Piro, D., Carbone, A., Castellani, S., & Di Gioia, S.
Affiliations
  • University of Foggia (IT)
  • Department of Medical and Surgical Sciences, University of Foggia, Viale L. Pinto 1, 71122 Foggia, Italy
Corresponding author
Conese, Massimo
ORCID
Venue
The Scientific World Journal
Publisher
Wiley
Published
2014
Volume
2014
Pages
1-11
ISSN
  • 1537-744X (ISSN-L)
  • 2356-6140
DOI
10.1155/2014/859817
PMC
PMC3916026
OpenAlex
W2008928656
Cited by
28
References
4
Citations by year
2024: 2 · 2022: 1 · 2021: 4 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 2
FWCI
0.86
Type
journal article
Language
en
Open access
Licence
Locations
  • The Scientific World JOURNAL (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Funders
Cystic Fibrosis Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Keywords
hematopoietic stem and progenitor cells, mesenchymal stem cells, stem cell plasticity, chronic lung disease, cystic fibrosis, asthma, chronic obstructive pulmonary disease, bone marrow-derived stem cells, engraftment, lung regeneration, stem cell heterogeneity, regenerative medicine, cell therapy
MeSH terms
Chronic Disease, Humans, Lung Diseases, Respiration Disorders, Hematopoietic Stem Cell Transplantation, Regenerative Medicine, Mesenchymal Stem Cell Transplantation

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