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Cited by 34Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular DisturbancesNeurological Disease Mechanisms and Treatments

Astroglia-Microglia Cross Talk during Neurodegeneration in the Rat Hippocampus

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Batlle, Montserrat, Ferri, Lorenzo, Andrade, Carmen, Ortega, Francisco-Javier, Vidal-Taboada, Jose M., Pugliese, Marco, Mahy, Nicole, Rodríguez, Manuel J.·2015·BioMed Research International
DOI 10.1155/2015/102419PMC PMC4419226
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Abstract

Brain injury triggers a progressive inflammatory response supported by a dynamic astroglia-microglia interplay. We investigated the progressive chronic features of the astroglia-microglia cross talk in the perspective of neuronal effects in a rat model of hippocampal excitotoxic injury. N-Methyl-D-aspartate (NMDA) injection triggered a process characterized within 38 days by atrophy, neuronal loss, and fast astroglia-mediated S100B increase. Microglia reaction varied with the lesion progression. It presented a peak of tumor necrosis factor-α(TNF-α) secretion at one day after the lesion, and a transient YM1 secretion within the first three days. Microglial glucocorticoid receptor expression increased up to day 5, before returning progressively to sham values. To further investigate the astroglia role in the microglia reaction, we performed concomitant transient astroglia ablation with L-α-aminoadipate and NMDA-induced lesion. We observed a striking maintenance of neuronal death associated with enhanced microglial reaction and proliferation, increased YM1 concentration, and decreased TNF-α secretion and glucocorticoid receptor expression. S100B reactivity only increased after astroglia recovery. Our results argue for an initial neuroprotective microglial reaction, with a direct astroglial control of the microglial cytotoxic response. We propose the recovery of the astroglia-microglia cross talk as a tissue priority conducted to ensure a proper cellular coordination that retails brain damage.

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  • Microglia and astrocytes coordinate their functions in many ways, both in the healthy and diseased brain.

    “However, recent data indicate that microglia and astrocytes coordinate their functions in many ways, both in the healthy and diseased brain [14–21].”

    From Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates (2021) · cites this paper as [19]

    The Introduction and Conclusions describe astrocyte–microglia interactions during neurodegeneration and brain injury, including astroglial influence on microglial responses. They do not establish coordination in the healthy brain, so that part of the cited sentence is not supported by this paper. (LLM, conf=0.86)

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  • Astrocytes are capable of stimulating microglia phagocytosis by secretion of cytokines such as IL33 and the complement protein C3.

    “Several studies have demonstrated that astrocytes are capable of stimulating microglia phagocytosis by secretion of cytokines such as IL33 and the complement protein C3 [19, 34].”

    From Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates (2021) · cites this paper as [19]

    The Introduction says astrocytes release S100B, which modulates microglial activity, and the Discussion describes a change in microglial phagocytic morphology after astrocyte depletion. Neither passage says astrocyte-secreted factors stimulate microglial phagocytosis, and the searched passages do not identify IL33 or C3 as mediators. Page numbers were not available in our copy. (LLM, conf=0.83)

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Cited by

Sorted by citations

Authors
Batlle, M., Ferri, L., Andrade, C., Ortega, F.-J., Vidal-Taboada, J. M., Pugliese, M., Mahy, N., & Rodríguez, M. J.
Affiliations
  • Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
  • Università Cattolica del Sacro Cuore (IT)
Corresponding author
Rodríguez, Manuel J.
ORCID
Venue
BioMed Research International
Publisher
Wiley
Published
2015
Volume
2015
Pages
1-15
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
DOI
10.1155/2015/102419
PMC
PMC4419226
OpenAlex
W2123227838
Cited by
34
References
1
Citations by year
2025: 2 · 2023: 8 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 2
FWCI
1.78
Type
journal article
Language
en
Open access
Licence
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Ministerio de Economia y Competitividad (IPT-2012-0614-010000)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
neuroinflammation, NMDA excitotoxicity, S100B, TNF-α, Ym1, glucocorticoid receptor, neuronal cell death, microglial proliferation, neuroprotection, astroglia
MeSH terms
Animals, Astrocytes, beta-N-Acetylhexosaminidases, Hippocampus, Nerve Degeneration, Neurons, Receptors, Glucocorticoid, Tumor Necrosis Factor-alpha, Gene Expression, N-Methylaspartate, Microglia, Cell Proliferation, Rats, S100 Calcium Binding Protein beta Subunit

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