Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species
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According to recent estimates, cancer continues to remain the second leading cause of death and is becoming the leading one in old age. Failure and high systemic toxicity of conventional cancer therapies have accelerated the identification and development of innovative preventive as well as therapeutic strategies to contrast cancer-associated morbidity and mortality. In recent years, increasing body of in vitro and in vivo studies has underscored the cancer preventive and therapeutic efficacy of the isothiocyanate sulforaphane. In this review article, we highlight that sulforaphane cytotoxicity derives from complex, concurring, and multiple mechanisms, among which the generation of reactive oxygen species has been identified as playing a central role in promoting apoptosis and autophagy of target cells. We also discuss the site and the mechanism of reactive oxygen species’ formation by sulforaphane, the toxicological relevance of sulforaphane-formed reactive oxygen species, and the death pathways triggered by sulforaphane-derived reactive oxygen species.
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Sulforaphane is a naturally occurring isothiocyanate found in broccoli and other cruciferous vegetables.
“Sulforaphane is a naturally occurring isothiocyanate (found in broccoli and other cruciferous vegetables) [63–65].”
From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [63]
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- Authors
- Sestili, P., & Fimognari, C.
- Affiliations
- University of Urbino (IT)
- University of Bologna (IT)
- Corresponding author
- Fimognari, Carmela
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-9
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC4491563
- OpenAlex
- W1499923741
- Cited by
- 90
- References
- 96
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 15 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 10 · 2018: 12 · 2017: 10 · 2016: 9
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- sulforaphane, reactive oxygen species, isothiocyanates, cytotoxicity, anticancer activity, apoptosis, autophagy, cancer prevention, cancer therapy, toxicology
- MeSH terms
- Animals, Antioxidants, Cell Survival, Cytotoxins, Dose-Response Relationship, Drug, Humans, Models, Biological, Neoplasms, Sulfoxides, Anticarcinogenic Agents, Treatment Outcome, Apoptosis, Reactive Oxygen Species, Isothiocyanates, Oxidative Stress
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