Cited by 90Genomics, phytochemicals, and oxidative stressBioactive Compounds and Antitumor AgentsCancer and biochemical research

Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species

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Sestili, Piero, Fimognari, Carmela·2015·BioMed Research International

Abstract

According to recent estimates, cancer continues to remain the second leading cause of death and is becoming the leading one in old age. Failure and high systemic toxicity of conventional cancer therapies have accelerated the identification and development of innovative preventive as well as therapeutic strategies to contrast cancer-associated morbidity and mortality. In recent years, increasing body of in vitro and in vivo studies has underscored the cancer preventive and therapeutic efficacy of the isothiocyanate sulforaphane. In this review article, we highlight that sulforaphane cytotoxicity derives from complex, concurring, and multiple mechanisms, among which the generation of reactive oxygen species has been identified as playing a central role in promoting apoptosis and autophagy of target cells. We also discuss the site and the mechanism of reactive oxygen species’ formation by sulforaphane, the toxicological relevance of sulforaphane-formed reactive oxygen species, and the death pathways triggered by sulforaphane-derived reactive oxygen species.

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Authors
Sestili, P., & Fimognari, C.
Affiliations
  • University of Urbino (IT)
  • University of Bologna (IT)
Corresponding author
Fimognari, Carmela
Venue
BioMed Research International
Publisher
Wiley
Published
2015
Volume
2015
Pages
1-9
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
OpenAlex
W1499923741
Cited by
90
References
96
Citations by year
2026: 1 · 2025: 5 · 2024: 15 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 10 · 2018: 12 · 2017: 10 · 2016: 9
FWCI
1.00
Type
journal article
Language
en
Open access
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords
sulforaphane, reactive oxygen species, isothiocyanates, cytotoxicity, anticancer activity, apoptosis, autophagy, cancer prevention, cancer therapy, toxicology
MeSH terms
Animals, Antioxidants, Cell Survival, Cytotoxins, Dose-Response Relationship, Drug, Humans, Models, Biological, Neoplasms, Sulfoxides, Anticarcinogenic Agents, Treatment Outcome, Apoptosis, Reactive Oxygen Species, Isothiocyanates, Oxidative Stress

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