Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems
Abstract
Sulforaphane is an isothiocyanate compound that has been derived from cruciferous vegetables. It was shown in numerous studies to be active against multiple cancer types including pancreatic, prostate, breast, lung, cervical, and colorectal cancers. Sulforaphane exerts its therapeutics action by a variety of mechanisms, such as by detoxifying carcinogens and oxidants through blockage of phase I metabolic enzymes, and by arresting cell cycle in the G2/M and G1 phase to inhibit cell proliferation. The most striking observation was the ability of sulforaphane to potentiate the activity of several classes of anticancer agents including paclitaxel, docetaxel, and gemcitabine through additive and synergistic effects. Although a good number of reviews have reported on the mechanisms by which sulforaphane exerts its anticancer activity, a comprehensive review on the synergistic effect of sulforaphane and its delivery strategies is lacking. Therefore, the aim of the current review was to provide a summary of the studies that have been reported on the activity enhancement effect of sulforaphane in combination with other anticancer therapies. Also provided is a summary of the strategies that have been developed for the delivery of sulforaphane.
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Sulforaphane is a naturally occurring isothiocyanate found in broccoli and other cruciferous vegetables.
“Sulforaphane is a naturally occurring isothiocyanate (found in broccoli and other cruciferous vegetables) [63–65].”
From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [65]
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An Update on Psychopharmacological Treatment of Autism Spectrum Disorder
Aishworiya, R., Valica, T., Hagerman, R., & Restrepo, B. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01183-1 · Cited by 233 · see citing works
Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives
Tănase, D. M., Gosav, E. M., Anton, M. I., Floria, M., Isac, P. N. S., Hurjui, L. L., Tărniceriu, C. C., Costea, C. F., Ciocoiu, M., & Rezuș, C. (2022) · Biomolecules · doi:10.3390/biom12091227 · Cited by 203 · see citing works
Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
Kaiser, A. E., Baniasadi, M., Giansiracusa, D., Giansiracusa, M., Garcia, M., Fryda, Z., Wong, T. L., & Bishayee, A. (2021) · Cancers · doi:10.3390/cancers13194796 · Cited by 161 · see citing works
Chang, X., Zhou, S., Yan, Z., Zhang, Q., Liu, J., Wang, Y., Guan, X., Wu, Q., & Liu, R. (2025) · Phytotherapy Research · doi:10.1002/ptr.70008 · Cited by 134 · see citing works
Syed, R. U., Moni, S. S., Break, M. K. B., Khojali, W. M. A., Jafar, M., Alshammari, M. D., Abdelsalam, K., Taymour, S., Alreshidi, K. S. M., Taha, M. M. E., et al. (2023) · Antibiotics · doi:10.3390/antibiotics12071157 · Cited by 102 · see citing works
Ma, C., Gu, C., Lian, P., Wazir, J., Lu, R., Ruan, B., Wei, L., Li, L., Pu, W., Peng, Z., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06234-9 · Cited by 88 · see citing works
Jacob, S., Rao, R., Gorain, B., Boddu, S. H. S., & Nair, A. B. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081079 · Cited by 81 · see citing works
Carbonic Anhydrase IX Inhibitors as Candidates for Combination Therapy of Solid Tumors
Kalinin, S., Михайловна, М. А., Sharonova, T. V., Sharoyko, V. V., Bunev, A. S., Supuran, C. T., & Krasavin, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413405 · Cited by 74 · see citing works
Anticancer properties of sulforaphane: current insights at the molecular level
Ali, M. A., Khan, N., Kaleem, N., Ahmad, W., Alharethi, S. H., Alharbi, B., Alhassan, H. H., Al-Enazi, M. M., Razis, A. F. A., Modu, B., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1168321 · Cited by 74 · see citing works
Waliat, S., Arshad, M. S., Hanif, H., Ejaz, A., Khalid, W., Kauser, S., & AL-Farga, A. M. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2176001 · Cited by 68 · see citing works
Dietary isothiocyanates inhibit cancer progression by modulation of epigenome
Sundaram, M. K., Preetha, R., Haque, S., Akhter, N., Khan, S. A., Ahmad, S., & Hussain, A. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.12.021 · Cited by 67 · see citing works
A Comparative Review of Key Isothiocyanates and Their Health Benefits
Olayanju, J. B., Božić, D., Naidoo, U., & Sadik, O. A. (2024) · Nutrients · doi:10.3390/nu16060757 · Cited by 64 · see citing works
Nanodelivery of natural isothiocyanates as a cancer therapeutic
Wang, Q., & Bao, Y. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.044 · Cited by 61 · see citing works
The Potential of Phytochemicals in Oral Cancer Prevention and Therapy: A Review of the Evidence
Lee, T., & Tseng, Y. (2020) · Biomolecules · doi:10.3390/biom10081150 · Cited by 62 · see citing works
Fahey, J. W., & Kensler, T. W. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.648788 · Cited by 55 · see citing works
Anticancer activity of broccoli, its organosulfur and polyphenolic compounds
Gasmi, A., Benahmed, A. G., Shanaida, M., Chirumbolo, S., Menzel, A., Anzar, W., Arshad, M., Martins, N. A., Lysiuk, R., Beley, N. M., et al. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2195493 · Cited by 55 · see citing works
Baralić, K., Živanović, J., Marić, Đ., Božić, D., Grahovac, L., Miljaković, E. A., Ćurčić, M., Djordjević, A. B., Bulat, Z., Antonijević, B., et al. (2024) · Antioxidants · doi:10.3390/antiox13020147 · Cited by 55 · see citing works
Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds
Choudhary, N., Bawari, S., Burcher, J. T., Sinha, D., Tewari, D., & Bishayee, A. (2023) · Cancers · doi:10.3390/cancers15153980 · Cited by 52 · see citing works
Novel treatments for autism spectrum disorder based on genomics and systems biology
Baribeau, D. A., & Anagnostou, E. A. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107939 · Cited by 50 · see citing works
Role of chemopreventive phytochemicals in NRF2-mediated redox homeostasis in humans
Chun, K., Raut, P. K., Kim, D., & Surh, Y. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.06.031 · Cited by 39 · see citing works
Lopes, J., Rodrigues, C. M. P., Gaspar, M. M., & Reis, C. P. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091817 · Cited by 37 · see citing works
Deng, W., Mei, X.-P., Cheng, Z.-J., gan, T.-X., Tian, X., Hu, J.-N., Zang, C.-R., Sun, B., Wu, J., Deng, Y., et al. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134817 · Cited by 30 · see citing works
Artés‐Hernández, F., Martínez‐Zamora, L., Cano‐Lamadrid, M., Hashemi, S., & Castillejo, N. (2023) · Foods · doi:10.3390/foods12030561 · Cited by 29 · see citing works
Quercetin-Induced Glutathione Depletion Sensitizes Colorectal Cancer Cells to Oxaliplatin
Lee, J., Jang, C. H., Kim, Y., Oh, J., & Kim, J. (2023) · Foods · doi:10.3390/foods12081733 · Cited by 29 · see citing works
Regulation of the Notch signaling pathway by natural products for cancer therapy
Cai, J., Qiao, Y., Chen, L., Lu, Y., & Zheng, D. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109483 · Cited by 28 · see citing works
Cano‐Lamadrid, M., Martínez‐Zamora, L., Castillejo, N., Cattaneo, C., Pagliarini, E., & Artés‐Hernández, F. (2023) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2023.112411 · Cited by 27 · see citing works
Mondal, D., Narwani, D., Notta, S., Ghaffar, D., Mardhekar, N. M., & Quadri, S. S. A. (2020) · Cancer Drug Resistance · doi:10.20517/cdr.2020.71 · Cited by 25 · see citing works
Men, X., Han, X., Lee, S.-J., Oh, G., Park, K.-T., Han, J.-K., Choi, S., & Lee, O. (2022) · Nutrients · doi:10.3390/nu14183814 · Cited by 25 · see citing works
Serviou, S. K., Gkizis, P. L., Sánchez, D. P., Plassais, N., Gohier, F., Cabanetos, C., & Kokotos, C. G. (2024) · ChemSusChem · doi:10.1002/cssc.202400903 · Cited by 23 · see citing works
Dietary isothiocyanates and anticancer agents: exploring synergism for improved cancer management
Wang, Q., Li, D., Liu, L., Shan, Y., & Bao, Y. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1386083 · Cited by 22 · see citing works
Fouad, G. I. (2023) · Cardiovascular Toxicology · doi:10.1007/s12012-022-09776-0 · Cited by 22 · see citing works
Ultrasound-Assisted Extraction of Bioactive Compounds from Broccoli By-Products
Martínez‐Zamora, L., Hashemi, S., Cano‐Lamadrid, M., Bueso, M. C., Aguayo, E., Kessler, M., & Artés‐Hernández, F. (2024) · Foods · doi:10.3390/foods13101441 · Cited by 22 · see citing works
Liu, F., Bai, Q., Tang, W., Zhang, S., Guo, Y. H., Pan, S., Ma, X., Yang, Y., & Fan, H. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1505153 · Cited by 19 · see citing works
Ngo, S. N. T., & Williams, D. B. (2020) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520620666200924104550 · Cited by 19 · see citing works
Napoli, E., Flores, A., Mansuri, Y., Hagerman, R. J., & Giulivi, C. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105427 · Cited by 19 · see citing works
Sulforaphane is a reversible covalent inhibitor of 3‐chymotrypsin‐like protease of SARS‐CoV‐2
Chen, Z., Du, R., Cooper, L. M., Achi, J. G., Dong, M., Ran, Y., Zhang, J., Zhan, P., Rong, L., & Cui, Q. (2023) · Journal of Medical Virology · doi:10.1002/jmv.28609 · Cited by 17 · see citing works
Zambrano, V., Bustos, R. O., Arozarena, Y., & Mahn, A. (2023) · Foods · doi:10.3390/foods12203869 · Cited by 17 · see citing works
Modulation of Nrf2 and Mitochondrial Function: Pharmacological Implications
Saso, L., Ateş, İ., Tunc, R., Yılmaz, B., Gallorini, M., Carradori, S., & Süzen, S. (2025) · Pharmaceuticals · doi:10.3390/ph18111698 · Cited by 18 · see citing works
Tuttis, K., Machado, A. R. T., dos Santos, P. W. D. S., & Antunes, L. M. G. (2023) · Nutrients · doi:10.3390/nu15122742 · Cited by 16 · see citing works
Moon, H.-W., & Ku, K. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1111069 · Cited by 15 · see citing works
Farani, M. R., Sarlak, M., Gholami, A., Azaraian, M., Binabaj, M. M., Kakavandi, S., Tambuwala, M. M., Taheriazam, A., Hashemi, M., & Ghasemi, S. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154688 · Cited by 15 · see citing works
Pogorzelska, A., Świtalska, M., Wietrzyk, J., Mazur, M., Milczarek, M., Medyńska, K., & Wiktorska, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-65455-w · Cited by 15 · see citing works
Effects of nanocarbon solution treatment on the nutrients and glucosinolate metabolism in broccoli
Li, Z., Liu, G., He, H., Liu, Y., Han, F., & Liu, W. (2022) · Food Chemistry X · doi:10.1016/j.fochx.2022.100429 · Cited by 15 · see citing works
Beneficial role of broccoli and its active ingredient, sulforaphane in the treatment of diabetes
Mohammed, A., & Mohammed, H. A. (2023) · Phytomedicine Plus · doi:10.1016/j.phyplu.2023.100431 · Cited by 14 · see citing works
Li, C., Zhang, L., Li, X., Hu, Q., Mao, L., Shao, Y., Han, M., Zhang, S., Ejaz, I., Mesbah, L., et al. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109803 · Cited by 14 · see citing works
Gao, L., Du, F., Wang, J., Zhao, Y., Liu, J., Cai, D., Zhang, X., Wang, Y., & Zhang, S. (2021) · Oncology Letters · doi:10.3892/ol.2021.12951 · Cited by 14 · see citing works
Neurofibromatosis: Molecular Pathogenesis and Natural Compounds as Potential Treatments
Amaravathi, A., Oblinger, J. L., Welling, D. B., Kinghorn, A. D., & Chang, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.698192 · Cited by 15 · see citing works
Martínez‐Zamora, L., Castillejo, N., & Artés‐Hernández, F. (2022) · Antioxidants · doi:10.3390/antiox11081490 · Cited by 14 · see citing works
Liver disorders in COVID-19, nutritional approaches and the use of phytochemicals
Vargas-Mendoza, N., García‐Machorro, J., Ángeles-Valencia, M., Martínez‐Archundia, M., Madrigal‐Santillán, E., Morales‐González, Á., Anguiano‐Robledo, L., & Morales‐González, J. A. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i34.5630 · Cited by 14 · see citing works
Adelakun, S. A., Akintunde, O. W., Ogunlade, B., & Adeyeluwa, B. E. (2022) · Morphologie · doi:10.1016/j.morpho.2022.05.002 · Cited by 13 · see citing works
Sita, G., Graziosi, A., Hrelia, P., & Morroni, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011201 · Cited by 12 · see citing works
An Update on Psychopharmacological Treatment of Autism Spectrum Disorder
Aishworiya, R., Valica, T., Hagerman, R. J., & Restrepo, B. (2024) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.24022006 · Cited by 15 · see citing works
Perspective on dietary isothiocyanates in the prevention, development and treatment of cancer
Yeger, H., & Mokhtari, R. B. (2020) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2020.61 · Cited by 12 · see citing works
Maphutha, J., Twilley, D., & Lall, N. (2024) · Molecules · doi:10.3390/molecules29030721 · Cited by 11 · see citing works
Božić, D., Živančević, K., Baralić, K., Miljaković, E. A., Djordjević, A. B., Ćurčić, M., Bulat, Z., Antonijević, B., & Đukić-Ćosić, D. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114316 · Cited by 11 · see citing works
Beneficial Diets and Pancreatic Cancer: Molecular Mechanisms and Clinical Practice
Zhang, Y., Zhang, T., Yang, W., Chen, H., Geng, X., Li, G., Chen, H., Wang, Y., Li, L., & Sun, B. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.630972 · Cited by 10 · see citing works
Process optimization for microfluidic preparation of liposomes using food-grade components
Hong, S.-C., Hong, C. R., Kim, M., Kang, Y. J., Jung, Y. H., Park, K.-M., Choi, J., & Chang, P.-S. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.139437 · Cited by 10 · see citing works
Wu, H., Witt, B. L., Pol, W. J. V. D., Morrow, C. D., Duck, L. W., & Tollefsbol, T. O. (2025) · Nutrients · doi:10.3390/nu17122023 · Cited by 10 · see citing works
Jiang, P., Jiang, W., Li, X., & Zhu, Q. (2024) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-024-04873-y · Cited by 10 · see citing works
Nrf2 paradox: Can cancer patients eat broccoli?
Surh, Y. (2021) · Food Frontiers · doi:10.1002/fft2.61 · Cited by 10 · see citing works
Naveed, T., Ali, S., & Summer, M. (2025) · Medical Oncology · doi:10.1007/s12032-025-02894-z · Cited by 9 · see citing works
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Wang, F., Li, S., Rosencrans, W. M., Cheng, K., Stott, G. M., Mroczkowski, B., & Chou, T. (2022) · ChemMedChem · doi:10.1002/cmdc.202200030 · Cited by 9 · see citing works
Tsaur, I., Thomas, A., Taskiran, E., Rutz, J., Chun, F. K. ‐., Haferkamp, A., Juengel, E., & Blaheta, R. A. (2022) · Cancers · doi:10.3390/cancers14194643 · Cited by 9 · see citing works
Broccoli Sprouts and Their Influence on Thyroid Function in Different In Vitro and In Vivo Models
Paśko, P., Zagrodzki, P., Okoń, K., Prochownik, E., Krośniak, M., & Galanty, A. (2022) · Plants · doi:10.3390/plants11202750 · Cited by 9 · see citing works
Integrative Management of Pancreatic Cancer (PDAC): Emerging Complementary Agents and Modalities
Djamgoz, M. B. A., & Jentzsch, V. (2021) · Nutrition and Cancer · doi:10.1080/01635581.2021.1934043 · Cited by 8 · see citing works
The intestinal stem cell as a target: A review
Faizo, N. L. (2024) · Medicine · doi:10.1097/md.0000000000039456 · Cited by 7 · see citing works
Peñata-Taborda, A., Espitia-Pérez, P., Espitia-Pérez, L., Coneo–Pretelt, A., Brango, H., Ricardo-Caldera, D., Arteaga, G. C., Jiménez-Vidal, L., Galeano–Páez, C., Pastor–Sierra, K., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031013 · Cited by 7 · see citing works
Adelakun, S. A., Akintunde, O. W., Ogunlade, B., Peter, A. B., & Siyanbade, J. A. (2024) · Aspects of Molecular Medicine · doi:10.1016/j.amolm.2024.100055 · Cited by 7 · see citing works
Sulforaphane: The Principal Broccoli Phytochemical as a Cancer Challenger
Djaldetti, M. (2022) · Recent Progress in Nutrition · doi:10.21926/rpn.2201008 · Cited by 7 · see citing works
Alshammari, A. N., Alfawaz, M. S., Alenezi, Y. M., Al-Ghafari, A. B., Doghaither, H. A. A., Elmorsy, E. M., Atta, M. M. F., & El‐Raghi, A. A. (2025) · BMC Cancer · doi:10.1186/s12885-025-15279-2 · Cited by 6 · see citing works
Are Aspects of Integrative Concepts Helpful to Improve Pancreatic Cancer Therapy?
Oei, S. L., & Schad, F. (2023) · Cancers · doi:10.3390/cancers15041116 · Cited by 6 · see citing works
Phytochemicals as the Source of Natural Immunomodulator and Their Role in Cancer Chemoprevention
Gupta, C., & Prakash, D. (2022) · Springer eBooks · doi:10.1007/978-981-16-6379-6_7 · Cited by 6 · see citing works
Chen, Y., Cui, R., Xiong, D., Zhao, Y., Pang, J., Gul, S., Qi, Q., Tang, Y., Zhou, X., & Tang, W. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30746 · Cited by 5 · see citing works
Zhang, G., Li, Y., & Sun, Y. (2024) · European Journal of Nutrition · doi:10.1007/s00394-024-03472-1 · Cited by 5 · see citing works
Ciriello, M., Izzo, L., Navarré, A., Campana, E., Colla, G., Corrado, G., Pascale, S. D., Rouphael, Y., & El‐Nakhel, C. (2025) · Foods · doi:10.3390/foods14142489 · Cited by 4 · see citing works
Efficacy and safety of sulforaphane-loaded emulsomes as tested on MCF7 and MCF10A cells
Karroum, R., & Üçışık, M. H. (2024) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2023-0210 · Cited by 4 · see citing works
Masoumvand, M., Ramezani, E., Milasi, Y. E., Rahimi, V. B., & Askari, V. R. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03706-3 · Cited by 3 · see citing works
Microgreens as Budding Medicine and Bountiful Source of Nutrition
Gupta, A., Sharma, T., Bhardwaj, V., Manojkumar, S. S., Sanjaykumar, D. Y., Singh, D., & Dhulipalla, M. (2025) · Springer eBooks · doi:10.1007/978-3-031-75678-8_26 · Cited by 3 · see citing works
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Bioactives and Bioactivities from Food Byproducts
Radha, Prakash, S., Kumari, N., Sharma, N., Puri, S., Singh, J., Thakur, M., Pundir, A., & Kumar, M. (2024) · Current Food Science and Technology Reports · doi:10.1007/s43555-024-00039-3 · Cited by 3 · see citing works
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Solarska‐Ściuk, K., Kapavarapu, R., Poliszak, Z., Wnuk, M., & Lewińska, A. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112033 · Cited by 2 · see citing works
Xenobiotic Sulforaphane in Head and Neck Cancer: Beyond the Nrf2 Pathway
Polizzi, A., Rotondo, R., Zeppa, S. D., Cecati, M., Smolik, M., Schiavoni, V., Montana, A., Pozzi, V., Sartini, D., Campagna, R., et al. (2026) · Journal of Xenobiotics · doi:10.3390/jox16030099 · Cited by 2 · see citing works
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Sulforaphane-Loaded Nanomedicines Applications: Trends on Inflammatory Diseases and Cancer Treatment
Nascimento, M. H. M., de Faria, N. C., & de Araújo, D. R. (2023) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-19-8342-9_15 · Cited by 2 · see citing works
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Reda, Y., Zong, C., Ikoma, A., Fergany, A., Ahmed, S., Naby, W. S. H. A. E., Ichihara, S., & Ichihara, G. (2025) · Toxicology Letters · doi:10.1016/j.toxlet.2025.111737 · Cited by 2 · see citing works
An innovative beverage made from revalorized broccoli and carrots by-products
Perez, P. F., Hashemi, S., Cano‐Lamadrid, M., Lorena, M. Z., Gómez, P. A., & Artés‐Hernández, F. (2024) · Acta Horticulturae · doi:10.17660/actahortic.2024.1387.25 · Cited by 2 · see citing works
Global pharmaceutical care approaches to autism spectrum disorder: a scoping review protocol
Sape, R. M., Shead, D. A., & Maseko, B. C. (2024) · JBI Evidence Synthesis · doi:10.11124/jbies-23-00247 · Cited by 1 · see citing works
Structural Elucidation and Storage Stability of Novel Dietary Sulfur Compounds from Radish
Jeong, G. A., Lee, I., Sung, J., & Lee, C. J. (2025) · Foods · doi:10.3390/foods14183254 · Cited by 1 · see citing works
Peng, Y., Liu, B., Guo, Y., Chen, J., Chen, H., Liu, X., Huang, J., Luo, D., Hong, Y., Wu, D., et al. (2025) · RSC Medicinal Chemistry · doi:10.1039/d5md00733j · Cited by 1 · see citing works
Marino, C., Magliocchetti, M., Lieto, D. D., Cione, E., Vocca, C., Ceccato, T., Botti, S., Palumbo, F., Gallelli, L., & Cai, T. (2026) · Urologia Journal · doi:10.1177/03915603251408298 · Cited by 1 · see citing works
Sulforaphane as a Multi-Scale Mechano-Modulator in Cancer: An Integrative Perspective
Zhang, X., Cheng, L., Han, Y., Chen, T., & Zhao, X. (2026) · Biology · doi:10.3390/biology15020167 · Cited by 1 · see citing works
Cao, J., Bao, J., Lan, S., Li, S., & Ma, S. (2026) · Industrial Crops and Products · doi:10.1016/j.indcrop.2026.123069 · Cited by 1 · see citing works
Therapeutic Implications of Phytochemicals in ROS Induced Cancer
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- Authors
- Kamal, M. M., Akter, S., Lin, C.-N., & Nazzal, S.
- Affiliations
- University of Louisiana at Monroe (US)
- Texas Woman's University (US)
- Texas Tech University Health Sciences Center (US)
- Corresponding author
- Nazzal, Sami
- Venue
- Archives of Pharmacal Research
- Published
- 2020-03-10
- Volume
- 43
- Issue
- 4
- Pages
- 371-384
- ISSN
- 0253-6269 (ISSN-L)
- 1976-3786
- OpenAlex
- W3012392756
- Cited by
- 115
- References
- 103
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 24 · 2023: 21 · 2022: 19 · 2021: 16 · 2020: 4
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Pharmacal Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Health Sciences › Medicine › Complementary and alternative medicine › Nigella sativa pharmacological applications
- Keywords
- sulforaphane, isothiocyanates, cruciferous vegetables, anticancer mechanism, drug synergy, drug potentiation, cell cycle arrest, G2/M cell cycle arrest, G1 cell cycle arrest, paclitaxel, docetaxel, gemcitabine, drug delivery systems, drug safety, chemoprevention
- MeSH terms
- Antineoplastic Agents, Humans, Neoplasms, Sulfoxides, Molecular Structure, Drug Delivery Systems, Isothiocyanates, Cell Proliferation, Cell Cycle Checkpoints
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