Cited by 115Genomics, phytochemicals, and oxidative stressBioactive Compounds and Antitumor AgentsNigella sativa pharmacological applications

Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems

Kamal, Mohammad M., Akter, Sharmin, Lin, Chin-Nu, Nazzal, Sami·2020·Archives of Pharmacal Research

Abstract

Sulforaphane is an isothiocyanate compound that has been derived from cruciferous vegetables. It was shown in numerous studies to be active against multiple cancer types including pancreatic, prostate, breast, lung, cervical, and colorectal cancers. Sulforaphane exerts its therapeutics action by a variety of mechanisms, such as by detoxifying carcinogens and oxidants through blockage of phase I metabolic enzymes, and by arresting cell cycle in the G2/M and G1 phase to inhibit cell proliferation. The most striking observation was the ability of sulforaphane to potentiate the activity of several classes of anticancer agents including paclitaxel, docetaxel, and gemcitabine through additive and synergistic effects. Although a good number of reviews have reported on the mechanisms by which sulforaphane exerts its anticancer activity, a comprehensive review on the synergistic effect of sulforaphane and its delivery strategies is lacking. Therefore, the aim of the current review was to provide a summary of the studies that have been reported on the activity enhancement effect of sulforaphane in combination with other anticancer therapies. Also provided is a summary of the strategies that have been developed for the delivery of sulforaphane.

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Crossref · 10.1007/s12272-020-01225-2

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103 of 103 references verified0 citation errors · 0 not checkable

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Authors
Kamal, M. M., Akter, S., Lin, C.-N., & Nazzal, S.
Affiliations
  • University of Louisiana at Monroe (US)
  • Texas Woman's University (US)
  • Texas Tech University Health Sciences Center (US)
Corresponding author
Nazzal, Sami
Venue
Archives of Pharmacal Research
Published
2020-03-10
Volume
43
Issue
4
Pages
371-384
ISSN
  • 0253-6269 (ISSN-L)
  • 1976-3786
OpenAlex
W3012392756
Cited by
115
References
103
Citations by year
2026: 13 · 2025: 17 · 2024: 24 · 2023: 21 · 2022: 19 · 2021: 16 · 2020: 4
FWCI
1.44
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Pharmacal Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
  • Health Sciences › Medicine › Complementary and alternative medicine › Nigella sativa pharmacological applications
Keywords
sulforaphane, isothiocyanates, cruciferous vegetables, anticancer mechanism, drug synergy, drug potentiation, cell cycle arrest, G2/M cell cycle arrest, G1 cell cycle arrest, paclitaxel, docetaxel, gemcitabine, drug delivery systems, drug safety, chemoprevention
MeSH terms
Antineoplastic Agents, Humans, Neoplasms, Sulfoxides, Molecular Structure, Drug Delivery Systems, Isothiocyanates, Cell Proliferation, Cell Cycle Checkpoints

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