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Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

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Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

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Bacterial infection causes stress-induced memory dysfunction in mice

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The Putative Antidepressant Mechanisms of Probiotic Bacteria: Relevant Genes and Proteins

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Probiotics Exert Protective Effect against Sepsis-Induced Cognitive Impairment by Reversing Gut Microbiota Abnormalities

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Dual-directional regulation of spinal cord injury and the gut microbiota

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Butyrate regulates inflammatory cytokine expression without affecting oxidative respiration in primary astrocytes from spontaneously hypertensive rats

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A narrative review on the use of probiotics in several diseases. Evidence and perspectives

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Tetragonia tetragonioides Protected against Memory Dysfunction by Elevating Hippocampal Amyloid-β Deposition through Potentiating Insulin Signaling and Altering Gut Microbiome Composition

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Atherosclerosis: The Culprit and Co-victim of Vascular Dementia

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Therapeutic Prospect of New Probiotics in Neurodegenerative Diseases

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Anti-depressant effect of Zhi-zi-chi decoction on CUMS mice and elucidation of its signaling pathway

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The emerging role of microbiota derived SCFAs in neurodegenerative disorders

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Modulation of Gut Microbiota in Pathological States

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Cultivable butyrate-producing bacteria of elderly Japanese diagnosed with Alzheimer’s disease

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Does the Gut Microbial Metabolome Really Matter? The Connection between GUT Metabolome and Neurological Disorders

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Effect of Clostridium butyricum on High-Fat Diet-Induced Intestinal Inflammation and Production of Short-Chain Fatty Acids

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Lingguizhugan decoction ameliorates cognitive impairment in AD-like mice by influencing the microbiome–gut–brain axis mediated by SCFAs

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A Systematic Review on the Effects of Different Types of Probiotics in Animal Alzheimer's Disease Studies

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The contribution of gut-brain axis to development of neurological symptoms in COVID-19 recovered patients: A hypothesis and review of literature

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Milk kefir alters fecal microbiota impacting gut and brain health in mice

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Prophylactic use of probiotics as an adjunctive treatment for ischemic stroke via the gut-spleen-brain axis

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Human Gut Microbiota and Mental Health: Advancements and Challenges in Microbe-Based Therapeutic Interventions

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Cerebral small vessel disease burden is associated with decreased abundance of gut Barnesiella intestinihominis bacterium in the Framingham Heart Study

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Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve

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Monobutyrin and Monovalerin Affect Brain Short-Chain Fatty Acid Profiles and Tight-Junction Protein Expression in ApoE-Knockout Rats Fed High-Fat Diets

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Low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate HDAC4 to promote apoptosis in rat hippocampal neurons

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Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration

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Diet-microbiome-gut-brain nexus in acute and chronic brain injury

Krakovski, M., Arora, N., Jain, S., Glover, J., Dombrowski, K. E., Hernandez, B., Yadav, H., & Sarma, A. K. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1002266 · Cited by 27

Dysregulation of the Gut Microbiota Contributes to Sevoflurane-Induced Cognitive Dysfunction in Aged Mice by Activating the NLRP3 Inflammasome

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Gut–brain axis and brain health: modulating neuroinflammation, cognitive decline, and neurodegeneration

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The microbiota-gut- hippocampus axis

Salami, M., & Soheili, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1065995 · Cited by 30

The microbiome and inborn errors of metabolism: Why we should look carefully at their interplay?

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Exploring the relationship between the gut microbiota and cognitive function in schizophrenia patients with distinct weights

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The role of probiotics, prebiotics, and postbiotics: cellular and molecular pathways activated on glial cells in Alzheimer’s disease

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Probiotic as a Potential Gut Microbiome Modifier for Stroke Treatment: A Systematic Scoping Review of In Vitro and In Vivo Studies

Savigamin, C., Samuthpongtorn, C., Mahakit, N., Nopsopon, T., Heath, J., & Pongpirul, K. (2022) · Nutrients · doi:10.3390/nu14173661 · Cited by 21

Microbial Reprogramming in Obsessive–Compulsive Disorders: A Review of Gut–Brain Communication and Emerging Evidence

Bendriss, G., MacDonald, R. S., & McVeigh, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511978 · Cited by 25

Metabolomics: The Key to Unraveling the Role of the Microbiome in Visceral Pain Neurotransmission

Shute, A., Bihan, D. G., Lewis, I. A., & Nasser, Y. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.917197 · Cited by 21

Gut microbiota in ischemic stroke: Where we stand and challenges ahead

Long, J.-X., Wang, J., Li, Y., & Chen, D. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1008514 · Cited by 22

Rhizoma Gastrodiae Water Extract Modulates the Gut Microbiota and Pathological Changes of P-TauThr231 to Protect Against Cognitive Impairment in Mice

Zhao, W., Wang, J., Latta, M., Wang, C., Liu, Y., Ma, W., Zhou, Z., Hu, S., Chen, P., & Liu, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.903659 · Cited by 20

Impact of cafeteria diet and n3 supplementation on the intestinal microbiota, fatty acids levels, neuroinflammatory markers and social memory in male rats

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The Involvement of Canonical Wnt Signaling in Memory Impairment Induced by Chronic Cerebral Hypoperfusion in Mice

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The Gut Microbiome and Its Impact on Mood and Decision-Making: A Mechanistic and Therapeutic Review

Diotaiuti, P., Misiti, F., Marotta, G., Falese, L., Calabrò, G. E., & Mancone, S. (2025) · Nutrients · doi:10.3390/nu17213350 · Cited by 24

Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1α/VEGF/TFEB-Activated Angiogenesis

Zhang, R., Zhao, T., Zheng, B., Zhang, Y. L., Li, X., Zhang, F., Cen, J., & Duan, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.648107 · Cited by 18

Mumefural Improves Recognition Memory and Alters ERK-CREB-BDNF Signaling in a Mouse Model of Chronic Cerebral Hypoperfusion

Kim, M., Kim, B., Kim, J. I., Lee, J., & Jeon, W. K. (2023) · Nutrients · doi:10.3390/nu15143271 · Cited by 18

NMR analysis seeking for cognitive decline and dementia metabolic markers in plasma from aged individuals.

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A Discovery of Relevant Hepatoprotective Effects and Underlying Mechanisms of Dietary Clostridium butyricum Against Corticosterone-Induced Liver Injury in Pekin Ducks

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Chronic exposure to ambient traffic-related air pollution (TRAP) alters gut microbial abundance and bile acid metabolism in a transgenic rat model of Alzheimer’s disease

Dutta, M., Weigel, K. M., Patten, K. T., Valenzuela, A. E., Wallis, C., Bein, K. J., Wexler, A. S., Lein, P. J., & Cui, J. Y. (2022) · Toxicology Reports · doi:10.1016/j.toxrep.2022.03.003 · Cited by 17

Combination of thalidomide and Clostridium butyricum relieves chemotherapy-induced nausea and vomiting via gut microbiota and vagus nerve activity modulation

Zhao, X., Wu, H., Zhu, R., Shang, G., Wei, J., Shang, H., Tian, P., Chen, T., & Wei, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1220165 · Cited by 17

Synthetic Biology Tools for Genome and Transcriptome Engineering of Solventogenic Clostridium

Kwon, S. W., Paari, K. A., Malaviya, A., & Jang, Y. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00282 · Cited by 17

Could the Gut Microbiota Serve as a Therapeutic Target in Ischemic Stroke?

Zhang, J., Tang, Q., & Zhu, L. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/1391384 · Cited by 17

The experimental research on neuroplasticity in rats’ hippocampus subjected to chronic cerebral hypoperfusion and interfered by Modified Dioscorea Pills

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Different Exercise Time on 5-HT and Anxiety-like Behavior in the Rat With Vascular Dementia

Fan, Y., Zhang, L., Kong, X., Liu, K., & Wu, H. (2022) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175221082743 · Cited by 16

The effect of probiotics on select cognitive domains in mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis

Tripathi, S., Kaushik, M., Dwivedi, R., Tiwari, P., Tripathi, M., & Dada, R. (2024) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823241289039 · Cited by 16

Higher dietary butyrate intake is associated with better cognitive function in older adults: evidence from a cross-sectional study

Tu, J., Zhang, J., & Chen, G. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1522498 · Cited by 16

Microbiota links to neural dynamics supporting threat processing

Hall, C. V., Harrison, B. J., Iyer, K. K., Savage, H. S., Zakrzewski, M., Simms, L. A., Radford‐Smith, G. L., Moran, R., & Cocchi, L. (2021) · Human Brain Mapping · doi:10.1002/hbm.25682 · Cited by 14

The involvement of the gut microbiota in postoperative cognitive dysfunction based on integrated metagenomic and metabolomics analysis

Zhang, S., Jia, X.-Y., Wu, Q., Jin, J., Xu, L., Yang, L., Han, J., & Zhou, Q. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.03104-23 · Cited by 17

Cell-Free Supernatant of Lactobacillus rhamnosus and Bifidobacterium breve Ameliorates Ischemic Stroke-Generated Neurological Deficits in Rats

Rahman, Z., Padhy, H. P., & Dandekar, M. P. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10256-w · Cited by 16

Anti-apoptotic effects of BDNF-TrkB signaling in the treatment of hemorrhagic stroke

Hasegawa, Y., Cheng, C., Hayashi, K., Takemoto, Y., & Kim‐Mitsuyama, S. (2020) · Brain Hemorrhages · doi:10.1016/j.hest.2020.04.003 · Cited by 14

Effect of 40 Hz light flicker on cognitive impairment and transcriptome of hippocampus in right unilateral common carotid artery occlusion mice

Niu, Z., Yu, M.-J., Xu, P., Liu, R., Li, S., Wu, C., Huang, B., Ye, X., Hu, J., Xu, Y., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-48897-6 · Cited by 14

Gut Microbiota Regulates Epigenetic Remodelling in the Amygdala: A Role in Repeated Mild Traumatic Brain Injury (rMTBI)-Induced Anxiety

Jadhav, G., Dudhabhate, B. B., Kokare, D. M., & Sakharkar, A. J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03697-x · Cited by 12

Treadmill exercise pretreatment ameliorated structural synaptic plasticity impairments of medial prefrontal cortex in vascular dementia rat and improved recognition memory

Zhang, L., Chen, Y., Fan, Y., & Shi, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-57080-4 · Cited by 12

Clostridium butyricum enhances cognitive function in APP/PS1 mice by modulating neuropathology and regulating acetic acid levels in the gut microbiota

Ye, S., Xinjie, L., Xiaotong, Z., Chen, J., Jia-hai, L., Xiaodong, C., Lou, Y., & Li, X. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.00178-25 · Cited by 12

Prebiotic effect of fructo-oligosaccharides on the inner ear of DBA/2 J mice with early-onset progressive hearing loss

Kondo, T., Saigo, S., Ugawa, S., Kato, M., Yoshikawa, Y., Miyoshi, N., & Tanabe, K. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108247 · Cited by 12

The Effect of Clostridium butyricum on Gut Microbial Changes and Functional Profiles of Metabolism in High-fat Diet–fed Rats Depending on Age and Sex

Choi, S. I., Kim, N., Choi, Y., Nam, R. H., Jang, J. Y., & Cho, S. (2024) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm23096 · Cited by 13

Role of inflammatory cytokines and the gut microbiome in vascular dementia: insights from Mendelian randomization analysis

Yang, Y., Rao, T., Sheng, W., Cheng, J., Zhan, Y., Lin, T., Chen, J., Zhong, X., Jiang, Y., & Yang, S. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1398618 · Cited by 13

Intriguing Role of Gut-Brain Axis on Cognition with an Emphasis on Interaction with Papez Circuit

Xavier, J., Anu, M., Fathima, A. S., Ravichandiran, V., & Kumar, N. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220614124145 · Cited by 11

Influence of fisetin combined with hesperidin on chronic mild hyperhomocysteinemia induced cognitive dysfunction and oxidative stress in wistar rats

Boyina, H. K., Jerald, M. K., Bharatraj, D. K., & Diwan, P. V. (2018) · PharmaNutrition · doi:10.1016/j.phanu.2018.06.003 · Cited by 11

The Potential Role of Microbiota in Age-Related Cognitive Decline: A Narrative Review of the Underlying Molecular Mechanisms

Olejnik, P., Golenia, A., & Małyszko, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041590 · Cited by 10

Molecular systems biology approaches to investigate mechanisms of gut−brain communication in neurological diseases

Vandemoortele, B., & Vermeirssen, V. (2023) · European Journal of Neurology · doi:10.1111/ene.15819 · Cited by 10

Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats

Quintanilla, M. E., Santapau, D., Díaz, E., Martı́nez, I., Medina, N., Landskron, G., Dominguez, A., Morales, P., Ramírez, D., Hermoso, M. A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-80228-1 · Cited by 9

The Association of Dietary Fatty Acids and Gut Microbiota Alterations in the Development of Neuropsychiatric Diseases: A Systematic Review

Kaur, K. K., Allahbadia, G. N., & Singh, M. (2020) · Obesity Research - Open Journal · doi:10.17140/oroj-7-143 · Cited by 9

The Potential of Clostridium butyricum to Preserve Gut Health, and to Mitigate Non-AIDS Comorbidities in People Living with HIV

Yang, Q., Zaongo, S. D., Zhu, L., Yan, J., Yang, J., & Ouyang, J. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10227-1 · Cited by 8

Oh my gut! Is the microbial origin of neurodegenerative diseases real?

Walker, A. C., & Czyż, D. M. (2023) · Infection and Immunity · doi:10.1128/iai.00437-22 · Cited by 11

Microglia and Microbiome-Gut-Brain Axis

Filho, A. M. C., Gomes, N. S., Lós, D. B., Leite, I. B., Tremblay, M., & Macêdo, D. S. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_17 · Cited by 8

Bioderived materials that disarm the gut mucosal immune system: Potential lessons from commensal microbiota

Harriman, R., & Lewis, J. S. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.05.045 · Cited by 9

The Microbiota-gut-brain axis in vascular cognitive impairment: unraveling the mysterious link and therapeutic prospects

Liu, T., Li, Y., Xiong, X., Lai, X., & Xu, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1648800 · Cited by 8

Microbiota–gut–brain axis and probiotics: potential therapeutic strategies for treating Alzheimer’s disease

Ajith, T. A., & Sreejith, J. K. (2025) · Nutritional Neuroscience · doi:10.1080/1028415x.2025.2567429 · Cited by 7

Draft Genome Sequence of Butyricimonas faecihominis 30A1, Isolated from Feces of a Japanese Alzheimer’s Disease Patient

Nguyen, T. T. T., Oshima, K., Toh, H., Khasnobish, A., Fujii, Y., Arakawa, K., & Morita, H. (2019) · Microbiology Resource Announcements · doi:10.1128/mra.00462-19 · Cited by 7

Foods may modify responsiveness to cancer immune checkpoint blockers by altering both the gut microbiota and activation of estrogen receptors in immune cells

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Gut Microbiota Metabolites Differentially Release Gliotransmitters from the Cultured Human Astrocytes: A Preliminary Report

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Additional file 1 of Amelioration of gut dysbiosis-induced cognitive deterioration by repeated administration of human clostridium butyricum: targeting intestinal and blood–brain barrier

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