Diabetes Remission after Nonsurgical Intensive Lifestyle Intervention in Obese Patients with Type 2 Diabetes
Open accessAbstract
Partial or complete remission from type 2 diabetes was recently observed after bariatric surgeries. Limited data is available about the possibility of inducing diabetes remission through intensive weight reduction. We retrospectively evaluated diabetes remissions after one year of the Weight Achievement and Intensive Treatment (Why WAIT) program, a 12-week intensive program for diabetes weight management in real-world clinical practice. Among 120 obese patients with type 2 diabetes who completed the program, 88 patients returned for follow-up at one year. Nineteen patients (21.6%) had major improvement in their glycemic control, defined as achieving an A1C <6.5% after one year. Four patients (4.5%) achieved either partial or complete diabetes remission defined as A1C <6.5% and <5.7%, respectively, on no antihyperglycemic medications for one year; 2 achieved partial remission (2.3%) and 2 achieved complete remission (2.3%). At the time of intervention, patients who achieved diabetes remission had shorter diabetes duration (<5 years) and lower A1C (<8%) and were treated with fewer than 2 oral medications. They achieved a weight reduction of >7% after 12 weeks. These results indicate that a subset of obese patients with type 2 diabetes is appropriate for intensive lifestyle intervention with the aim of inducing diabetes remission.
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A fraction of individuals are successful at long-term weight loss maintenance and true disease remission is uncommon.
“However, a fraction of individuals are successful at long-term weight loss maintenance and true disease remission is uncommon [3, 9].”
From Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study (2018) · cites this paper as [9]
The Results report that only 4 of 88 patients achieved partial or complete diabetes remission at one year, supporting the claim that remission is uncommon. They also report maintained weight loss among those who achieved remission, but do not establish what fraction of all participants maintained weight loss long term; follow-up was limited to one year. (LLM, conf=0.85)
Experimental — accuracy not yet measuredSome studies subdivided results as previously proposed by Buse et al.
“Some studies [54–57] subdivided results as previously proposed by Buse et al. [58].”
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- Authors
- Mottalib, A., Sakr, M., Shehabeldin, M., & Hamdy, O.
- Affiliations
- Joslin Diabetes Center (US)
- Corresponding author
- Hamdy, Osama
- Venue
- Journal of Diabetes Research
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-4
- ISSN
- 2314-6745 (ISSN-L)
- 2314-6753
- PMC
- PMC4465710
- OpenAlex
- W1509973842
- Cited by
- 44
- References
- 30
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 1 · 2022: 8 · 2021: 5 · 2020: 1 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 4
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Update notices
- corrigendum (2016-01-06)
- Open access
- gold
- doi.org
- Locations
- Journal of Diabetes Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- type 2 diabetes remission, intensive lifestyle intervention, obesity, weight loss, glycemic control, HbA1c, diabetes duration
- MeSH terms
- Boston, Combined Modality Therapy, Diabetes Mellitus, Type 2, Diet, Reducing, Drug Therapy, Combination, Follow-Up Studies, Glycated Hemoglobin, Humans, Hyperglycemia, Hypoglycemic Agents, Life Style, Middle Aged, Obesity, Patient Education as Topic, Remission Induction, Retrospective Studies, Weight Loss, Exercise, Cognitive Behavioral Therapy, Body Mass Index, Drug Monitoring, Precision Medicine
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