Association of an intensive lifestyle intervention with remission of type 2 diabetes
Open accessAbstract
CONTEXT: The frequency of remission of type 2 diabetes achievable with lifestyle intervention is unclear. OBJECTIVE: To examine the association of a long-term intensive weight-loss intervention with the frequency of remission from type 2 diabetes to prediabetes or normoglycemia. DESIGN, SETTING, AND PARTICIPANTS: Ancillary observational analysis of a 4-year randomized controlled trial (baseline visit, August 2001-April 2004; last follow-up, April 2008) comparing an intensive lifestyle intervention (ILI) with a diabetes support and education control condition (DSE) among 4503 US adults with body mass index of 25 or higher and type 2 diabetes. INTERVENTIONS: Participants were randomly assigned to receive the ILI, which included weekly group and individual counseling in the first 6 months followed by 3 sessions per month for the second 6 months and twice-monthly contact and regular refresher group series and campaigns in years 2 to 4 (n=2241) or the DSE, which was an offer of 3 group sessions per year on diet, physical activity, and social support (n=2262). MAIN OUTCOME MEASURES: Partial or complete remission of diabetes, defined as transition from meeting diabetes criteria to a prediabetes or nondiabetic level of glycemia (fasting plasma glucose <126 mg/dL and hemoglobin A1c <6.5% with no antihyperglycemic medication). RESULTS Intensive lifestyle intervention participants lost significantly more weight than DSE participants at year 1 (net difference, -7.9%; 95% CI, -8.3% to -7.6%) and at year 4 (-3.9%; 95% CI, -4.4% to -3.5%) and had greater fitness increases at year 1 (net difference, 15.4%; 95% CI, 13.7%-17.0%) and at year 4 (6.4%; 95% CI, 4.7%-8.1%) (P < .001 for each). The ILI group was significantly more likely to experience any remission (partial or complete), with prevalences of 11.5% (95% CI, 10.1%-12.8%) during the first year and 7.3% (95% CI, 6.2%-8.4%) at year 4, compared with 2.0% for the DSE group at both time points (95% CIs, 1.4%-2.6% at year 1 and 1.5%-2.7% at year 4) (P < .001 for each). Among ILI participants, 9.2% (95% CI, 7.9%-10.4%), 6.4% (95% CI, 5.3%-7.4%), and 3.5% (95% CI, 2.7%-4.3%) had continuous, sustained remission for at least 2, at least 3, and 4 years, respectively, compared with less than 2% of DSE participants (1.7% [95% CI, 1.2%-2.3%] for at least 2 years; 1.3% [95% CI, 0.8%-1.7%] for at least 3 years; and 0.5% [95% CI, 0.2%-0.8%] for 4 years). CONCLUSIONS: In these exploratory analyses of overweight adults, an intensive lifestyle intervention was associated with a greater likelihood of partial remission of type 2 diabetes compared with diabetes support and education. However, the absolute remission rates were modest. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00017953.
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A weight reduction of 5% or more brings further health benefits, such as preventing or resolving type 2 diabetes, lowering blood pressure and lipids, improving non-alcoholic fatty liver disease, and alleviating urinary incontinence and sexual dysfunction.
“Weight loss of this size confers additional health benefits beyond those described above. These include prevention and resolution of type 2 diabetes,11,12 reduction in blood pressure and lipids,13–14 amelioration of non-alcoholic fatty liver disease,15 and improvements in urinary incontinence and sexual dysfunction.16,17”
From Eight-year weight losses with an intensive lifestyle intervention: The look AHEAD study (2014) · cites this paper as [12]
The Results report that remission was more common among participants with greater weight loss, including those who lost more than 6.5% of their weight. The Comment reports diabetes-prevention findings from other studies, but this paper studied remission in adults who already had type 2 diabetes; it does not establish a 5% threshold for either outcome. The other listed benefits are attached to different citations in the citing sentence. (LLM, conf=0.84)
Experimental — accuracy not yet measuredSeveral approaches have been reported to elicit T2D remission including surgery, intensive insulin therapy upon diagnosis, and nutrition therapy utilizing significant caloric and/or dietary carbohydrate restriction.
“Several approaches have been reported to elicit T2D remission including surgery, intensive insulin therapy upon diagnosis, and nutrition therapy utilizing significant caloric and/or dietary carbohydrate restriction [4][5][6][7].”
From 5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study (2024) · cites this paper as [5]
The Abstract and COMMENT report remission following bariatric surgery, and the Intervention and COMMENT describe a calorie-reducing lifestyle program associated with partial or complete remission. The paper does not report remission from intensive insulin therapy upon diagnosis or from dietary carbohydrate restriction; its dietary intervention reduced calories and fat and included physical activity. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredShorter duration of diabetes, lower fasting insulin, and less medication use at enrollment were factors associated with remission in the present investigation, consistent with previous studies.
“However, shorter duration of diabetes, lower fasting insulin, and less medication use at enrollment were factors associated with remission in the present investigation, consistent with findings reported in previous studies [5,7].”
From 5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study (2024) · cites this paper as [5]
The Results (page not available in our copy) associate remission with fewer years since diabetes diagnosis and not taking insulin at baseline. They do not identify lower fasting insulin as a predictor; the reported measure is lower baseline HbA1c. The medication finding is also narrower than less medication use generally. (LLM, conf=0.88)
Experimental — accuracy not yet measuredA fraction of individuals are successful at long-term weight loss maintenance and true disease remission is uncommon.
“However, a fraction of individuals are successful at long-term weight loss maintenance and true disease remission is uncommon [3, 9].”
From Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study (2018) · cites this paper as [3]
The Comment section says complete type 2 diabetes remission after intensive lifestyle intervention is rare, and the Results report a low absolute prevalence. The Results also show average weight loss at four years, but do not establish what fraction of individuals successfully maintained long-term weight loss. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIntensive lifestyle interventions are effective treatments for obese individuals with T2D when weight loss is achieved and sustained.
“Intensive lifestyle interventions are effective treatments for obese individuals with T2D when weight loss is achieved and sustained [3].”
From Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study (2018) · cites this paper as [3]
The COMMENT reports higher remission rates with intensive lifestyle intervention than with diabetes support and education among overweight adults with type 2 diabetes, particularly those with substantial weight loss. But complete remission was rare, and the paper says its four-year follow-up could not fully assess how long remission lasted. It therefore supports a benefit for some patients, not an unqualified claim of effective treatment when weight loss is sustained. (LLM, conf=0.84)
Experimental — accuracy not yet measured
An intensive lifestyle intervention resulted in remission rates (both partial and complete) of 11.5% and 9.2% at 1 and 2 years.
“while an intensive lifestyle intervention resulted in remission rates (both partial and complete) of 11.5 and 9.2% at 1 and 2 years (5).”
From Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial (2019) · cites this paper as [5]
The Results report 11.5% partial or complete remission during year 1. They report 9.2% for remission sustained for at least two years at some point during follow-up, not the remission rate in year 2; the year-2 complete-case prevalence was 10.4%. (LLM, conf=0.90)
Experimental — accuracy not yet measuredLook AHEAD delivered a heavily supported programme in specialist centres, combining physical activity and dietary programme, and achieved a mean weight loss of 8.6 kg.
“Look AHEAD 21 delivered a heavily supported programme in specialist centres, combining physical activity and dietary programme, and achieved a mean weight loss of 8•6 kg.”
From Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial (2018) · cites this paper as [21]
The Study Design and Intervention sections describe 16 US research centers and frequent counseling combining dietary changes with increased physical activity. The Results report mean first-year weight loss of 8.6%, not 8.6 kg; the claimed unit is unsupported. (LLM, conf=0.90)
Experimental — accuracy not yet measuredIn Look AHEAD, risk factor management was improved with reduced utilization of antihypertensive medications, statins, and insulin.
“Risk factor management was improved with reduced utilization of antihypertensive medications, statins, and insulin (82).”
From 13. Older Adults: <i>Standards of Care in Diabetes—2024</i> (2024) · cites this paper as [82]
The COMMENT section reports improved HDL cholesterol, triglycerides, and systolic blood pressure in Look AHEAD, and the RESULTS and COMMENT sections report diabetes remission without drug treatment in some intervention participants (page numbers unavailable). The paper does not report reduced utilization of antihypertensives, statins, or insulin as claimed; its mention of insulin use concerns baseline status as a predictor of remission. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIn Look AHEAD, risk factor management was improved with reduced utilization of antihypertensive medications, statins, and insulin.
“Risk factor management was improved with reduced utilization of antihypertensive medications, statins, and insulin (89).”
From 13. Older Adults: Standards of Care in Diabetes—2025 (2025) · cites this paper as [89]
The Comment section reports improvements in HDL cholesterol, triglycerides, and systolic blood pressure in Look AHEAD. The Results report more diabetes remission with the lifestyle intervention, and remission required being off diabetes medication. However, this paper does not report reduced use of antihypertensives, statins, or insulin across the intervention group; its insulin and hypertension-medication figures describe baseline characteristics or predictors of remission, not reductions in use. (LLM, conf=0.87)
Experimental — accuracy not yet measuredRisk factor management improved with reduced use of antihypertensive medications, statins, and insulin in the Look AHEAD trial.
“Risk factor management improved with reduced use of antihypertensive medications, statins, and insulin”
From 13. Older Adults: Standards of Care in Diabetes—2026 (2026) · cites this paper as [100]
The COMMENT section reports improvements in cholesterol measures and systolic blood pressure in Look AHEAD, while the RESULTS section reports more diabetes remission without antihyperglycemic medication in the intensive-intervention group. Our copy does not report reduced use of antihypertensive medications, statins, or insulin as claimed; its mentions of baseline antihypertensive and insulin use are not evidence of reductions. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIn the Look AHEAD trial, the intensive lifestyle arm resulted in at least partial diabetes remission in 11.5% of participants compared with 2% in the control group.
“the intensive lifestyle arm resulted in at least partial diabetes remission in 11.5% of participants as compared with 2% in the control group (177).”
From Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report (2019) · cites this paper as [177]
Evidence of T2D remission beyond two years is sparse.
“Evidence of T2D remission beyond two years is sparse, with examples in bariatric surgery and following the three lifestyle interventions: 1) meal replacements for caloric restriction and physical activity [5,7,8]; 2) short-term total diet replacement with rescue therapy for weight maintenance [9]; and 3) a calorie-restricted Mediterranean diet [10].”
Previous studies consistently report that weight loss increases the likelihood of T2D remission.
“Previous studies consistently report that weight loss increases the likelihood of T2D remission (4, 5, 9).”
Length of time with a T2D diagnosis is a factor in remission, with longer time since diagnosis resulting in lower remission.
“Length of time with a T2D diagnosis is a factor in remission, with longer time since diagnosis resulting in lower remission (4, 5, 9).”
The 2 year remission rate (both partial and complete) in the CCI (17.6%) is higher than that achieved through intensive lifestyle intervention (ILI) in the Look AHEAD trial (9.2%).
“The 2 year remission rate (both partial and complete) in the CCI (17.6%) is higher than that achieved through intensive lifestyle intervention (ILI) in the Look AHEAD trial (9.2%) (5).”
The Look AHEAD trial and the Diabetes Remission Clinical Trial highlight the potential for type 2 diabetes remission in people undergoing weight loss treatment.
“The Look AHEAD trial (177) and the DiabetesRemissionClinicalTrial(DiRECT) (138) highlight the potential for type 2 diabetes remission d defi ned as the maintenance of euglycemia (complete remission) or prediabetes level of glycemia (partial remission) with no diabetes medication for at least 1 year (177,178) d in people undergoing weight loss treatment.”
From Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report (2019) · cites this paper as [177]
Individuals in the intervention group of Look AHEAD were more likely to experience partial diabetes remission during the first four years of the trial.
“Further, we recently reported that individuals in the intervention group of Look AHEAD were more likely to experience partial diabetes remission during the first four years of the trial.19”
From Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes (2013) · cites this paper as [19]
Evidence of long-term protection against cardiovascular disease events and mortality exists only for the Mediterranean diet.
“However, evidence of long-term protection against CVD events and mortality exists only for the Mediterranean diet.698,724–726”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [726]
The COMMENT section (page not available in our copy) reports that the Look AHEAD intensive lifestyle intervention did not reduce cardiovascular events. Our copy does not discuss whether the Mediterranean diet protects against cardiovascular events or mortality, or whether it is the only diet with such evidence (searched: Mediterranean diet, cardiovascular mortality). (LLM, conf=0.76)
Experimental — accuracy not yet measuredIn the Lyon Diet Heart Study, people with previous myocardial infarction randomized to a Mediterranean diet had lower rates of reinfarction and mortality after 4 years than those randomized to a northern European diet.
“Persons who had a previous MI were randomized to a Mediterranean diet or a diet typically consumed in northern European countries, and after 4 years, the Mediterranean diet group had reduced rates of reinfarction and mortality.”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [726]
The Study Design and Results sections describe the Look AHEAD trial in adults with type 2 diabetes, not the Lyon Diet Heart Study. Searches for the Lyon study, a Mediterranean diet, reinfarction, and a northern European diet found no passage addressing the claimed comparison or its four-year outcomes; page numbers were unavailable in our copy. (LLM, conf=0.77)
Experimental — accuracy not yet measuredThe strongest evidence on eating patterns for preventing type 2 diabetes in prediabetes concerns Mediterranean-style diets.
“The most robust research available regarding eating/meal patterns for T2D prevention in prediabetes pertains to Mediterranean-style diets.698,724–726,814–816”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [726]
The Intervention section describes calorie and fat reduction, physical activity, and meal replacements for participants who already had type 2 diabetes. The Comment section discusses remission and cites diabetes-prevention studies, but neither section assesses Mediterranean-style diets or ranks the evidence on eating patterns for prevention in prediabetes. Searches for Mediterranean-style diets and dietary patterns found no passage addressing that claim. (LLM, conf=0.76)
Experimental — accuracy not yet measuredOnly Mediterranean-style diets have long-term safety data showing protection against cardiovascular events, cardiovascular mortality, and all-cause mortality.
“However, the long-term safety data demonstrating protection against CVD events, CVD mortality, and all-cause mortality is only available for Mediterranean-style diets.724,726”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [726]
The COMMENT section reports that the Look AHEAD intensive lifestyle intervention did not reduce cardiovascular events, but it does not evaluate Mediterranean-style diets. Searches for Mediterranean-style diets, long-term diet safety, cardiovascular mortality, and all-cause mortality found no passage establishing the claimed protection or its exclusivity. (LLM, conf=0.77)
Experimental — accuracy not yet measuredMediterranean-style diets provide primary and secondary protection against cardiovascular events, cardiovascular mortality, and all-cause mortality in study populations about 50% with diabetes.
“In addition, RCTs have demonstrated primary724 and secondary726 protection against CVD events, CVD mortality, and all-cause mortality in study populations comprised of ~50% with DM.724”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [726]
The COMMENT section discusses diabetes remission after an intensive lifestyle intervention, not trials of Mediterranean-style diets. It notes that this intervention did not reduce cardiovascular events, but that finding does not establish whether Mediterranean-style diets provide the claimed primary or secondary protection. Searches for Mediterranean diets, cardiovascular mortality, all-cause mortality, and populations approximately 50% with diabetes found no passage addressing the claim. (LLM, conf=0.76)
Experimental — accuracy not yet measuredRecidivism in glycemia is typically observed across all interventions in diabetes, including pharmaceutical interventions.
“Although recidivism in glycemia is typically observed across all interventions in diabetes [4,5,6,29] including pharmaceutical interventions [3,37]”
From 5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study (2024) · cites this paper as [5]
The Results (page unavailable) report that some participants returned to clinical diabetes status after remission in the lifestyle-intervention and support-and-education groups. The citation is attached specifically to the claim about pharmaceutical interventions; our copy mentions their effects on HbA1c but does not report glycemic recidivism following them. I searched for pharmaceutical-intervention relapse and recurrence. (LLM, conf=0.74)
Experimental — accuracy not yet measuredFive studies compared diet interventions with usual care according to clinical guidelines, without providing foods or dietary products for participants.
“Five studies compared diet interventions with usual care according to clinical guidelines, without providing foods or dietary products for participants [49–53].”
Among trials reporting post hoc analyses for remission, one using two meal replacements/day during 0-20 weeks and one per day thereafter reported 11% remission at 1 year, with mean weight loss 8.6 kg, compared with 2% in standard care (N = 4503; GRADE low certainty; some concern over risk of bias).
“Among trials reporting post hoc analyses for remission, one using two meal replacements/day during 0–20 weeks and one per day thereafter reported 11% (247/2157) remission at 1 year (prevalence estimates), with mean weight loss 8.6 kg, compared with 2% (43/2170) in standard care (N = 4503; GRADE low certainty of evidence), with some concern over risk of bias [49].”
Among these five studies, three provided diabetes education or advice.
“Among these, three provided diabetes education or advice (Table 2) [49, 50, 52].”
In the Diabetes Prevention Program, a single restoration to normal fasting and 2-hour glucose levels during the intervention was linked to a lower subsequent diabetes incidence, largely through better β-cell function.
“in the Diabetes Prevention Program (DPP) restoring individuals to normal fasting and 2-hour glucose levels only once during the intervention phase was associated with a reduced rate of subsequently developing diabetes, due largely to improved β-cell function157.”
From Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future (2014) · cites this paper as [157]
The Look AHEAD, DiRECT and DIADEM-I trials highlighted the potential for T2DM remission with a weight loss of 15 kg or more within one year following a low or very low-calorie diet, and also using meal replacements.
“The Look AHEAD Trial, the Diabetes Remission Clinical Trial (DiRECT) and the Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I) highlighted the potential for T2DM remission, defined as the maintenance of euglycemia (complete remission) or prediabetes level of glycemia (partial remission) with no diabetes medication for at least 1 year, with a weight loss of 15 kg or more”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [125]
In the Look AHEAD trial, the intensive lifestyle arm resulted in at least partial diabetes remission in 12% of participants compared with 2% in the control group.
“In the Look AHEAD trial, when compared with the control group, the intensive lifestyle arm (more visits, 175 min/week unsupervised physical activity, dietary modification counseling, and a weight loss goal of 10%) resulted in at least partial diabetes remission in 12% of participants as compared with 2% in the control group [125].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [125]
Large lifestyle-intervention trials such as the Diabetes Prevention Program and Look AHEAD have shown beneficial effects on controlling and reversing diabetes.
“Large studies, like the National Diabetes Prevention Program (DPP) and the Look AHEAD (Action for Health in Diabetes) trial, have shown the beneficial effects of lifestyle interventions in controlling and reversing diabetes.”
From The Impact of Physical Activity in Patients With Type 2 Diabetes (2025) · cites this paper as [6]
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Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report
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Nutrition therapy recommendations for the management of adults with diabetes
Evert, A. B., Boucher, J. L., Cypress, M., Dunbar, S. A., Franz, M. J., Mayer-Davis, E. J., Neumiller, J. J., Nwankwo, R., Verdi, C. L., Urbanski, P., et al. (2013) · Diabetes Care · doi:10.2337/dc13-2042 · Cited by 1,129 · see citing works
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“Remission of type 2 diabetes was not the primary outcome in Look Ahead, but was observed in 9·2% at 2 years, with average weight loss of a little under 6kg.(21) The DiRECT intervention has similarities with Look Ahead, but was designed specifically for achieving remissions, with a view to delivery at scale for the ver…”
MethodBushnell, C., McCullough, L. D., Awad, I. A., Chireau, M. V., Fedder, W. N., Furie, K. L., Howard, V. J., Lichtman, J. H., Lisabeth, L. D., Piña, I. L., et al. (2014) · Stroke · doi:10.1161/01.str.0000442009.06663.48 · Cited by 941 · see citing works
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“These include prevention and resolution of type 2 diabetes (11,12), reduction in blood pressure and lipids (13,14), amelioration of nonalcoholic fatty liver disease (15), and improvements in urinary incontinence and sexual dysfunction (16,17).”
Nutrition therapy recommendations for the management of adults with diabetes
Evert, A. B., Boucher, J. L., Cypress, M., Dunbar, S. A., Franz, M. J., Mayer-Davis, E. J., Neumiller, J. J., Nwankwo, R., Verdi, C. L., Urbanski, P., et al. (2014) · Diabetes Care · doi:10.2337/dc14-s120 · Cited by 766 · see citing works
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The importance of weight management in type 2 diabetes mellitus
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“Length of time with a T2D diagnosis is a factor in remission, with longer time since diagnosis resulting in lower remission (4, 5, 9).”
BackgroundUnderstanding the mechanisms of reversal of type 2 diabetes
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- Authors
- Gregg, E. W., Chen, H., Wagenknecht, L. E., Clark, J. M., Delahanty, L. M., Bantle, J., Pownall, H. J., Johnson, K. C., Safford, M. M., Kitabchi, A. E., Pi-Sunyer, F. X., Wing, R. R., Bertoni, A. G., & Look AHEAD Research Group, F. T.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Wake Forest University (US)
- Johns Hopkins Medicine (US)
- Harvard University (US)
- University of Minnesota (US)
- Baylor College of Medicine (US)
- University of Tennessee Health Science Center (US)
- University of Alabama (US)
- Brown University (US)
- Corresponding author
- Gregg, Edward W.
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2012-12-19
- Volume
- 308
- Issue
- 23
- Pages
- 2489
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC4771522
- OpenAlex
- W1970727299
- Cited by
- 752
- References
- 34
- Citations by year
- 2026: 37 · 2025: 66 · 2024: 55 · 2023: 67 · 2022: 70 · 2021: 59 · 2020: 47 · 2019: 54 · 2018: 32 · 2017: 44 · 2016: 45 · 2015: 56 · 2014: 66 · 2013: 49 · 2012: 2
- FWCI
- 44.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (CC999999, 5p30dk046204-15)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-57171, DK 57136, DK57149, DK 57002, DK57182, DK56990, (DK 046204, DK57008, DK57177, DK 57078, DK57219, U01DK057149, DK-57178, U01DK057151, U01DK057135, U01DK057131, U01DK056990, DK-57135, U01DK057136, DK-56992, DK57154, U01DK057178, U01DK057182, U01DK057078, K24DK062222, U01DK057154, U01DK057008, R01DK083393, U01DK057171, DK57131, R01DK060427, U01DK057002, R01DK089557, U01DK057219, U01DK056992, U01DK057177, P30DK017047, P30DK048520, DK 57151, R01DK048117, P30-DK046204)
- National Center for Research Resources (M01-RR-0021140, M01RR002719, M01RR000056, M01RR000051, M01RR001066, M01RR001346, UL1RR024153)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 2 diabetes remission, intensive lifestyle intervention, weight loss, prediabetes, diabetes support and education, glycemic control, physical fitness, obesity, diabetes prevention, lifestyle counseling, long-term follow-up, fasting blood glucose, HbA1c, diabetes complications, diabetes-related hospitalization, diabetes-related quality of life
- MeSH terms
- Aged, Blood Glucose, Counseling, Diabetes Mellitus, Type 2, Diet, Female, Humans, Life Style, Male, Middle Aged, Patient Education as Topic, Psychotherapy, Group, Remission Induction, Social Support, Weight Loss, Exercise, Body Mass Index, Treatment Outcome, Risk Reduction Behavior, Overweight
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