The DOI matches its Crossref record; 216 of the 216 references it cites were found in a registry or an index.
Neuroplasticity Underlying the Comorbidity of Pain and Depression
Open accessAbstract
Acute pain induces depressed mood, and chronic pain is known to cause depression. Depression, meanwhile, can also adversely affect pain behaviors ranging from symptomology to treatment response. Pain and depression independently induce long-term plasticity in the central nervous system (CNS). Comorbid conditions, however, have distinct patterns of neural activation. We performed a review of the changes in neural circuitry and molecular signaling pathways that may underlie this complex relationship between pain and depression. We also discussed some of the current and future therapies that are based on this understanding of the CNS plasticity that occurs with pain and depression.
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Cites
1 retracted
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Cited by
TFOS DEWS II Sex, Gender, and Hormones Report
Sullivan, D. A., Rocha, E. M., Aragona, P., Clayton, J. A., Ding, J., Golebiowski, B., Hampel, U., McDermott, A. M., Schaumberg, D. A., Srinivasan, S., et al. (2017) · The Ocular Surface · doi:10.1016/j.jtos.2017.04.001 · Cited by 434
Insular Cortex is Critical for the Perception, Modulation, and Chronification of Pain
Lu, C., Yang, T., Zhao, H., Zhang, M., Meng, F., Fu, H., Xie, Y., & Xu, H. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-016-0016-y · Cited by 270
Comorbidity between pain and mental illness—evidence of a bidirectional relationship
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“Both clinical and preclinical studies clearly indicate that pain can cause depression and that depression can worsen pain behaviours.(47) In turn, depression and pain share biological pathways and neurotransmitters.”
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Self-citation
Metadata
- Authors
- Doan, L., Manders, T., & Wang, J.
- Venue
- Neural Plasticity
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-16
- ISSN
- 1687-5443 (ISSN-L)
- 2090-5904
- OpenAlex
- W1982188027
- Cited by
- 282
- References
- 216
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- gold
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