The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Diabetic Retinopathy: Vascular and Inflammatory Disease
Open accessAbstract
Diabetic retinopathy (DR) is the leading cause of visual impairment in the working-age population of the Western world. The pathogenesis of DR is complex and several vascular, inflammatory, and neuronal mechanisms are involved. Inflammation mediates structural and molecular alterations associated with DR. However, the molecular mechanisms underlying the inflammatory pathways associated with DR are not completely characterized. Previous studies indicate that tissue hypoxia and dysregulation of immune responses associated with diabetes mellitus can induce increased expression of numerous vitreous mediators responsible for DR development. Thus, analysis of vitreous humor obtained from diabetic patients has made it possible to identify some of the mediators (cytokines, chemokines, and other factors) responsible for DR pathogenesis. Further studies are needed to better understand the relationship between inflammation and DR. Herein the main vitreous-related factors triggering the occurrence of retinal complication in diabetes are highlighted.
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Cites
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“Hyperglycemia is the main culprit in DR development; it affects the levels of plasma cytokines (TNF-α and IL-6) implicated in insulin resistance [26].”
BackgroundSignaling in innate immunity and inflammation
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Xu, G.-T., Zhang, J.-F., & Tang, L. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.355743 · Cited by 280
Age-related eye disease and gender
Zetterberg, M. (2016) · Maturitas · doi:10.1016/j.maturitas.2015.10.005 · Cited by 185
Sala-Vila, A., Díaz-López, A., Valls-Pedret, C., Cofán, M., García-Layana, A., Lamuela-Raventós, R.-M., Castañer, O., Zanon-Moreno, V., Martinez-Gonzalez, M. A., Toledo, E., et al. (2016) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2016.2906 · Cited by 124
Nanoparticulate drug delivery to the retina
Li, Q., Weng, J., Wong, S. N., Thomas Lee, W. Y., & Chow, S. F. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00224 · Cited by 59
Liu, W., Tzeng, T.-F., & Liu, I.-M. (2016) · Molecules · doi:10.3390/molecules21121708 · Cited by 30
Metadata
- Authors
- Semeraro, F., Cancarini, A., dell’Omo, R., Rezzola, S., Romano, M. R., & Costagliola, C.
- Venue
- Journal of Diabetes Research
- Publisher
- Hindawi Limited
- Published
- 2015
- Volume
- 2015
- Pages
- 1-16
- ISSN
- 2314-6745 (ISSN-L)
- 2314-6753
- OpenAlex
- W1518103124
- Cited by
- 424
- References
- 9
- FWCI
- 33.58
- Type
- journal article
- Language
- en
- Open access
- gold
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- Semeraro, F., Cancarini, A., dell’Omo, R., Rezzola, S., Romano, M. R., & Costagliola, C. (2015). Diabetic Retinopathy: Vascular and Inflammatory Disease. Journal of Diabetes Research. https://doi.org/10.1155/2015/582060
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
