The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Exosomes: Novel Biomarkers for Clinical Diagnosis
Open accessAbstract
Exosomes are 30–120 nm endocytic membrane‐derived vesicles that participate in cell‐to‐cell communication and protein and RNA delivery. Exosomes harbor a variety of proteins, nucleic acids, and lipids and are present in many and perhaps all bodily fluids. A significant body of literature has demonstrated that molecular constituents of exosomes, especially exosomal proteins and microRNAs (miRNAs), hold great promise as novel biomarkers for clinical diagnosis. In this minireview, we summarize recent advances in the research of exosomal biomarkers and their potential application in clinical diagnostics. We also provide a brief overview of the formation, function, and isolation of exosomes.
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Cites
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
B lymphocytes secrete antigen-presenting vesicles.
Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546
Saman, S., Kim, W., Raya, M., Visnick, Y., Miro, S., Saman, S., Jackson, B., McKee, A. C., Alvarez, V. E., Lee, N. C. Y., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277061 · Cited by 985
Microfluidic isolation and transcriptome analysis of serum microvesicles
Chen, C., Skog, J., Hsu, C.-H., Lessard, R. T., Balaj, L., Wurdinger, T., Carter, B. S., Breakefield, X. O., Toner, M., & Irimia, D. (2010) · Lab Chip · doi:10.1039/b916199f · Cited by 572
Role of Pancreatic Cancer-derived Exosomes in Salivary Biomarker Development
Lau, C., Kim, Y., Chia, D., Spielmann, N., Eibl, G., Elashoff, D., Wei, F., Lin, Y.-L., Moro, A., Grogan, T., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.452458 · Cited by 256
Cited by
MicroRNA as Biomarkers and Diagnostics
Wang, J., Chen, J., & Sen, S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25056 · Cited by 793
Brites, D., & Fernandes, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00476 · Cited by 599
“Exosomal miRNAs have been indicated as a promising platform for compartment biomarker and early detection of diseases, including brain disorders (Cheng et al., 2014; Khalyfa and Gozal, 2014; Hornick et al., 2015; Lin et al., 2015; Schwarzenbach, 2015).”
BackgroundShin, H., Jeong, H., Park, J., Hong, S., & Choi, Y. (2018) · ACS Sensors · doi:10.1021/acssensors.8b01047 · Cited by 246
Role of Alix in miRNA packaging during extracellular vesicle biogenesis
IAVELLO, A., FRECH, V. S. L., GAI, C., DEREGIBUS, M. C., QUESENBERRY, P. J., & CAMUSSI, G. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2488 · Cited by 175
Molecular diagnostics of neurodegenerative disorders
Agrawal, M., & Biswas, A. (2015) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2015.00054 · Cited by 164
Metadata
- Authors
- Lin, J., Li, J., Huang, B., Liu, J., Chen, X., Chen, X.-M., Xu, Y.-M., Huang, L.-F., & Wang, X.-Z.
- Venue
- The Scientific World Journal
- Publisher
- Wiley
- Published
- 2015-01
- Volume
- 2015
- Issue
- 1
- Pages
- 657086-657086
- ISSN
- 1537-744X (ISSN-L)
- 2356-6140
- OpenAlex
- W2019081320
- Cited by
- 562
- References
- 6
- FWCI
- 16.34
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lin, J., Li, J., Huang, B., Liu, J., Chen, X., Chen, X.-M., Xu, Y.-M., Huang, L.-F., & Wang, X.-Z. (2015). Exosomes: Novel Biomarkers for Clinical Diagnosis. The Scientific World Journal. https://doi.org/10.1155/2015/657086
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
