MicroRNA as Biomarkers and Diagnostics
Open accessAbstract
MicroRNAs (miRNAs) are a group of small non-coding RNAs that are involved in regulating a range of developmental and physiological processes; their dysregulation has been associated with development of diseases including cancer. Circulating miRNAs and exosomal miRNAs have also been proposed as being useful in diagnostics as biomarkers for diseases and different types of cancer. In this review, miRNAs are discussed as biomarkers for cancer and other diseases, including viral infections, nervous system disorders, cardiovascular disorders, and diabetes. We summarize some of the clinical evidence for the use of miRNAs as biomarkers in diagnostics and provide some general perspectives on their use in clinical situations. The analytical challenges in using miRNAs in cancer and disease diagnostics are evaluated and discussed. Validation of specific miRNA signatures as biomarkers is a critical milestone in diagnostics.
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Extracellular miRNAs function as chemical messengers to mediate cell-cell communication.
“Extracellular miRNAs function as chemical messengers to mediate cell-cell communication.”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [22]
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Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
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“Indeed, miRNAs are involved in many biological processes and their dysregulations have been associated with human diseases [3].”
BackgroundHe, C., Aziguli, A., Zhen, J., Jiao, A., Liao, H., Du, C., Liu, W., Aihemaitijiang, K., & Xu, A. (2022) · Translational Cancer Research · doi:10.21037/tcr-22-1732 · Cited by 7 · see citing works
- Authors
- Wang, J., Chen, J., & Sen, S.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Sen, Subrata
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2015-09-28
- Volume
- 231
- Issue
- 1
- Pages
- 25-30
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- PMC
- PMC8776330
- OpenAlex
- W2105686255
- Cited by
- 793
- References
- 120
- Citations by year
- 2026: 42 · 2025: 79 · 2024: 94 · 2023: 73 · 2022: 100 · 2021: 103 · 2020: 100 · 2019: 80 · 2018: 62 · 2017: 33 · 2016: 22 · 2015: 4 · 2014: 1
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health, National Cancer Institute, USA (U01 CA111302)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- microRNA, biomarkers, cancer diagnosis, circulating microRNAs, exosomal microRNAs, non-coding RNA, viral infection, neurological disorders, cardiovascular disease, diabetes mellitus, analytical challenges
- MeSH terms
- Animals, Autoimmune Diseases, Cardiovascular Diseases, Humans, Neoplasms, Biomarkers, Tumor, Genetic Predisposition to Disease, MicroRNAs
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