The Influence of Aging on the Regenerative Potential of Human Adipose Derived Mesenchymal Stem Cells
Open accessAbstract
Tissue regeneration using human adipose derived mesenchymal stem cells (hASCs) has significant potential as a novel treatment for many degenerative bone and joint diseases. Previous studies have established that age negatively affects the proliferation status and the osteogenic and chondrogenic differentiation potential of mesenchymal stem cells. The aim of this study was to assess the age‐related maintenance of physiological function and differentiation potential of hASCs in vitro. hASCs were isolated from patients of four different age groups: (1) >20 years ( n = 7), (2) >50 years ( n = 7), (3) >60 years ( n = 7), and (4) >70 years ( n = 7). The hASCs were characterized according to the number of fibroblasts colony forming unit (CFU‐F), proliferation rate, population doubling time (PDT), and quantified parameters of adipogenic, chondrogenic, and osteogenic differentiation. Compared to younger cells, aged hASCs had decreased proliferation rates, decreased chondrogenic and osteogenic potential, and increased senescent features. A shift in favor of adipogenic differentiation with increased age was also observed. As many bone and joint diseases increase in prevalence with age, it is important to consider the negative influence of age on hASCs viability, proliferation status, and multilineage differentiation potential when considering the potential therapeutic applications of hASCs.
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MSCs derived from older individuals or those with underlying health conditions, such as HBV infection, may exhibit impaired proliferative, differentiation, and regenerative capacities, leading to ineffective treatments or unfavorable clinical outcomes.
“MSCs derived from older individuals or those with underlying health conditions, such as HBV infection, may exhibit impaired proliferative, differentiation, and regenerative capacities, leading to ineffective treatments or unfavorable clinical outcomes [315, 316].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [315]
The Results (§3.1) report lower proliferation in adipose-derived MSCs from older donors, and the Discussion (§5) reports reduced osteogenic and chondrogenic potential and a possible limitation for therapeutic use. The paper does not examine HBV infection or demonstrate ineffective treatments or unfavorable clinical outcomes; its clinical implications are prospective. Page numbers were not supplied in our copy. (LLM, conf=0.87)
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- Authors
- Marędziak, M., Marycz, K., Tomaszewski, K. A., Kornicka, K., & Henry, B. M.
- Affiliations
- Wrocław University of Environmental and Life Sciences (PL)
- Jagiellonian University (PL)
- Corresponding author
- Marycz, Krzysztof
- ORCID
- Venue
- Stem Cells International
- Publisher
- Wiley
- Published
- 2016-01
- Volume
- 2016
- Issue
- 1
- Pages
- 2152435-2152435
- ISSN
- 1687-966X (ISSN-L)
- 1687-9678
- PMC
- PMC4749808
- OpenAlex
- W2286064488
- Cited by
- 225
- References
- 54
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 15 · 2023: 13 · 2022: 19 · 2021: 34 · 2020: 31 · 2019: 29 · 2018: 24 · 2017: 22 · 2016: 13
- FWCI
- 21.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cells International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Wrocław Centre of Biotechnology
- Foundation for Polish Science
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- human adipose-derived mesenchymal stem cells, aging, cellular senescence, multilineage differentiation, osteogenic differentiation, chondrogenic differentiation, adipogenesis, cell proliferation, population doubling time, CFU-F, tissue regeneration
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