The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation
Open accessAbstract
Toll-like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs). They are highly conserved receptors that recognize conserved pathogen-associated molecular patterns (PAMPs), thus representing the first line of defense against infections. TLR4 has been long recognized as the sensing receptor for gram-negative lipopolysaccharide (LPS). In addition, it also binds endogenous molecules produced as a result of tissue injury. Hence, TLR4 represents a key receptor on which both infectious and noninfectious stimuli converge to induce a proinflammatory response. TLR4-mediated inflammation, triggered by exogenous or endogenous ligands, is also involved in several acute and chronic diseases, having a pivotal role as amplifier of the inflammatory response. This review focuses on the research progress about the role of TLR4 activation in infectious and noninfectious (e.g., sterile) inflammation and the effects of TLR4 signaling in some pathological conditions.
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CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4
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Cited by
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling
Ciesielska, A., Matyjek, M., & Kwiatkowska, K. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03656-y · Cited by 1,420
Chitosan oligosaccharide (COS): An overview
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Aboudounya, M. M., & Heads, R. J. (2021) · Mediators of Inflammation · doi:10.1155/2021/8874339 · Cited by 346
Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review
Razali, N. N. M., Ng, C. T., & Fong, L. Y. (2019) · Planta Medica · doi:10.1055/a-1008-6138 · Cited by 95
Metadata
- Authors
- Molteni, M., Gemma, S., & Rossetti, C.
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-9
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- OpenAlex
- W2403366498
- Cited by
- 446
- References
- 22
- FWCI
- 16.82
- Type
- journal article
- Language
- en
- Open access
- gold
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