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Cited by 95Medicinal Plants and NeuroprotectionPhytochemicals and Medicinal PlantsNatural product bioactivities and synthesis

Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review

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Razali, Nur Nadia Mohd, Ng, Chin Theng, Fong, Lai Yen·2019·Planta Medica
DOI 10.1055/a-1008-6138
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Abstract

Centella asiatica, a triterpene-rich medicinal herb, is traditionally used to treat various types of diseases including neurological, dermatological, and metabolic diseases. A few articles have previously reviewed a broad range of pharmacological activities of C. asiatica, but none of these reviews focuses on the use of C. asiatica in cardiovascular diseases. This review aims to summarize recent findings on protective effects of C. asiatica and its active constituents (asiatic acid, asiaticoside, madecassic acid, and madecassoside) in cardiovascular diseases. In addition, their beneficial effects on conditions associated with cardiovascular diseases were also reviewed. Articles were retrieved from electronic databases such as PubMed and Google Scholar using keywords “Centella asiatica,” “asiatic acid,” “asiaticoside,” “madecassic acid,” and “madecassoside.” The articles published between 2004 and 2018 that are related to the aforementioned topics were selected. A few clinical studies published beyond this period were also included. The results showed that C. asiatica and its active compounds possess potential therapeutic effects in cardiovascular diseases and cardiovascular disease-related conditions, as evidenced by numerous in silico, in vitro, in vivo, and clinical studies. C. asiatica and its triterpenes have been reported to exhibit cardioprotective, anti-atherosclerotic, antihypertensive, antihyperlipidemic, antidiabetic, antioxidant, and anti-inflammatory activities. In conclusion, more clinical and pharmacokinetic studies are needed to support the use of C. asiatica and its triterpenes as therapeutic agents for cardiovascular diseases. Besides, elucidation of the molecular pathways modulated by C. asiatica and its active constituents will help to understand the mechanisms underlying the cardioprotective action of C. asiatica.

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  • Various extracts and compounds isolated from C. asiatica lower occurrence of cardiovascular diseases such as cardiac hypertrophy, myocardial ischaemia, atherosclerosis and hypertension.

    “Various extracts and compounds isolated from C. asiatica are seen to lower the occurrence of cardiovascular diseases such as cardiac hypertrophy, myocardial ischaemia, atherosclerosis and hypertension.”

    From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [125]

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Authors
Razali, N. N. M., Ng, C. T., & Fong, L. Y.
Affiliations
  • Universiti Tunku Abdul Rahman Sungai Long Campus (MY)
  • AIMST University (MY)
ORCID
Venue
Planta Medica
Publisher
Georg Thieme Verlag KG
Published
2019-09-20
Volume
85
Issue
16
Pages
1203-1215
ISSN
  • 0032-0943 (ISSN-L)
  • 1439-0221
DOI
10.1055/a-1008-6138
OpenAlex
W2973845216
Cited by
95
References
5
Citations by year
2026: 7 · 2025: 14 · 2024: 17 · 2023: 16 · 2022: 13 · 2021: 21 · 2020: 6 · 2014: 1
FWCI
2.05
Type
journal article
Language
en
Open access
Locations
  • Planta Medica (publishedVersion)
  • PubMed (publishedVersion)
Funders
Universiti Tunku Abdul Rahman
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
Keywords
Centella asiatica, triterpenoids, asiatic acid, asiaticoside, madecassic acid, madecassoside, cardioprotection, cardiovascular disease, atherosclerosis, hypertension, hyperlipidemia, antidiabetic activity, antioxidant activity, anti-inflammatory activity, medicinal plants
MeSH terms
Cardiovascular Diseases, Humans, Plant Extracts, Plants, Medicinal, Triterpenes, Centella, Pentacyclic Triterpenes

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