The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome
Open accessAbstract
Macrophages are highly plastic cells. Under different stimuli, macrophages can be polarized into several different subsets. Two main macrophage subsets have been suggested: classically activated or inflammatory (M1) macrophages and alternatively activated or anti-inflammatory (M2) macrophages. Macrophage polarization is governed by a highly complex set of regulatory networks. Many recent studies have shown that macrophages are key orchestrators in the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and that regulation of macrophage polarization may improve the prognosis of ALI/ARDS. A further understanding of the mechanisms of macrophage polarization is expected to be helpful in the development of novel therapeutic targets to treat ALI/ARDS. Therefore, we performed a literature review to summarize the regulatory mechanisms of macrophage polarization and its role in the pathogenesis of ALI/ARDS. A computer-based online search was performed using the PubMed database and Web of Science database for published articles concerning macrophages, macrophage polarization, and ALI/ARDS. In this review, we discuss the origin, polarization, and polarization regulation of macrophages as well as the role of macrophage polarization in various stages of ARDS. According to the current literature, regulating the polarized state of macrophages might be a potential therapeutic strategy against ALI/ARDS.
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Cites
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Cited by
Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective
Pérez, S., & Rius-Pérez, S. (2022) · Antioxidants · doi:10.3390/antiox11071394 · Cited by 312
Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury
Zhou, X., & Liao, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.779620 · Cited by 153
“Thus, the regulation of macrophage polarization from M1 to M2 may be a novel therapeutic strategy of ALI/ARDS (Chen et al., 2020).”
BackgroundRole of gut microbes in acute lung injury/acute respiratory distress syndrome
Ren, Z., Zheng, Z., & Feng, X. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2440125 · Cited by 48
Exosomes: efficient macrophage-related immunomodulators in chronic lung diseases
Kang, J., Hua, P., Wu, X., & Wang, B. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1271684 · Cited by 22
Fan, M., Xiao, H., Song, D., Zhu, L., Zhang, J., Zhang, X., Wang, J., Dai, H., & Wang, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.848435 · Cited by 16
Metadata
- Authors
- Chen, X., Tang, J., Shuai, W., Meng, J., Feng, J., & Han, Z.
- Venue
- Inflammation Research
- Published
- 2020-07-10
- Volume
- 69
- Issue
- 9
- Pages
- 883-895
- ISSN
- 1023-3830 (ISSN-L)
- 1420-908X
- OpenAlex
- W3041595964
- Cited by
- 423
- References
- 112
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chen, X., Tang, J., Shuai, W., Meng, J., Feng, J., & Han, Z. (2020). Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome. Inflammation Research. https://doi.org/10.1007/s00011-020-01378-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
