The Role of the Cognitive Control System in Recovery from Bilingual Aphasia: A Multiple Single-Case fMRI Study
Open accessAbstract
Aphasia in bilingual patients is a therapeutic challenge since both languages can be impacted by the same lesion. Language control has been suggested to play an important role in the recovery of first (L1) and second (L2) language in bilingual aphasia following stroke. To test this hypothesis, we collected behavioral measures of language production (general aphasia evaluation and picture naming) in each language and language control (linguistic and nonlinguistic switching tasks), as well as fMRI during a naming task at one and four months following stroke in five bilingual patients suffering from poststroke aphasia. We further applied dynamic causal modelling (DCM) analyses to the connections between language and control brain areas. Three patients showed parallel recovery in language production, one patient improved in L1, and one improved in L2 only. Language-control functions improved in two patients. Consistent with the dynamic view of language recovery, DCM analyses showed a higher connectedness between language and control areas in the language with the better recovery. Moreover, similar degrees of connectedness between language and control areas were found in the patients who recovered in both languages. Our data suggest that engagement of the interconnected language-control network is crucial in the recovery of languages.
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Cognitive skills may be even more crucial in bilingual contexts due to the interaction between heightened EC demands and the neural infrastructure supporting bilingual lexical access.
“These skills may be even more crucial in bilingual contexts due to the interaction between heightened EC demands and the neural infrastructure supporting bilingual lexical access56,58–60.”
From Machine Learning Predictions of Recovery in Bilingual Poststroke Aphasia: Aligning Insights With Clinical Evidence (2025) · cites this paper as [60]
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“60 These ML-derived insights, consistent with theoretical and clinical evidence, emphasize the need to consider both language-specific and domain-general cognitive abilities in bPWA assessment and intervention.”
- Authors
- Radman, N., Mouthon, M., Di Pietro, M., Gaytanidis, C., Leemann, B., Abutalebi, J., & Annoni, J.-M.
- Affiliations
- University of Fribourg (CH)
- Neurology Unit, Department of Medicine, Faculty of Sciences, University of Fribourg, Fribourg, Switzerland
- Neurorehabilitation Department, University Hospital, University of Geneva, Geneva, Switzerland
- University of Geneva (CH)
- Vita-Salute San Raffaele University (IT)
- Corresponding author
- Radman, Narges
- Venue
- Neural Plasticity
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-22
- ISSN
- 1687-5443 (ISSN-L)
- 2090-5904
- PMC
- PMC5124691
- OpenAlex
- W2551106252
- Cited by
- 35
- References
- 45
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 4 · 2017: 2
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Neural Plasticity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- Swiss National Foundation for Science (32-138497, 325130-156937)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
- Keywords
- bilingual aphasia, post-stroke aphasia, language recovery, cognitive control, language control, dynamic causal modeling, picture naming, language switching
- MeSH terms
- Aged, Aphasia, Basal Ganglia, Cerebral Cortex, Cognition, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Psychomotor Performance, Multilingualism, Recovery of Function, Stroke
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