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Cited by 52Alcohol Consumption and Health EffectsAntioxidant Activity and Oxidative StressLiver Disease and Transplantation

Behavior of Oxidative Stress Markers in Alcoholic Liver Cirrhosis Patients

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Galicia-Moreno, Marina, Rosique-Oramas, Dorothy, Medina-Avila, Zaira, Álvarez-Torres, Tania, Falcón, Dalia, Higuera-de la tijera, Fátima, Béjar, Yadira L., Cordero-Pérez, Paula +4 more·2016·Oxidative Medicine and Cellular Longevity
DOI 10.1155/2016/9370565PMC PMC5198187
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Abstract

Alcohol is the most socially accepted addictive substance worldwide, and its metabolism is related with oxidative stress generation. The aim of this work was to evaluate the role of oxidative stress in alcoholic liver cirrhosis (ALC). This study included 187 patients divided into two groups: ALC, classified according to Child‐Pugh score, and a control group. We determined the levels of reduced and oxidized glutathione (GSH and GSSG) and the GSH/GSSG ratio by an enzymatic method in blood. Also, protein carbonyl and malondialdehyde (MDA) content were estimated in serum. MDA levels increased in proportion to the severity of damage, whereas the GSH and GSSG levels decreased and increased, respectively, at different stages of cirrhosis. There were no differences in the GSH/GSSG ratio and carbonylated protein content between groups. We also evaluated whether the active consumption of or abstinence from alcoholic beverages affected the behavior of these oxidative markers and only found differences in the MDA, GSH, and GSSG determination and the GSH/GSSG ratio. Our results suggest that alcoholic cirrhotic subjects have an increase in oxidative stress in the early stages of disease severity and that abstinence from alcohol consumption favors the major antioxidant endogen: GSH in patients with advanced disease severity.

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Authors
Galicia-Moreno, M., Rosique-Oramas, D., Medina-Avila, Z., Álvarez-Torres, T., Falcón, D., Higuera-de la tijera, F., Béjar, Y. L., Cordero-Pérez, P., Muñoz-Espinosa, L., Pérez-Hernández, J. L., Kershenobich, D., & Gutierrez-Reyes, G.
Affiliations
  • Hospital General de México (MX)
  • Universidad Autónoma de Nuevo León (MX)
ORCID
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2016-01
Volume
2016
Issue
1
Pages
9370565-9370565
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
DOI
10.1155/2016/9370565
PMC
PMC5198187
OpenAlex
W2566694324
Cited by
52
References
2
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 1 · 2021: 9 · 2020: 5 · 2019: 9 · 2018: 5 · 2017: 3
FWCI
5.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Universidad Nacional Autónoma de México (IA 203113, TA200515)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords
alcoholic cirrhosis, oxidative stress, glutathione, glutathione disulfide, GSH/GSSG ratio, malondialdehyde, protein carbonyls, alcohol abstinence, alcohol consumption, Child-Pugh score, disease severity
MeSH terms
Adult, Alanine Transaminase, Aspartate Aminotransferases, Female, Glutathione, Humans, Liver, Liver Cirrhosis, Alcoholic, Male, Malondialdehyde, Middle Aged, Severity of Illness Index, Biomarkers, Case-Control Studies, Oxidative Stress, Glutathione Disulfide, Protein Carbonylation

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