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Cited by 740Alcohol Consumption and Health EffectsSubstance Abuse Treatment and OutcomesGlobal Public Health Policies and Epidemiology

Global burden of alcoholic liver diseases

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Rehm, Jürgen, Samokhvalov, Andriy V., Shield, Kevin D.·2013·Journal of Hepatology
DOI 10.1016/j.jhep.2013.03.007
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Abstract

Liver diseases contribute markedly to the global burden of mortality and disease. This paper provides an overview from a global perspective of the contribution of alcohol to liver diseases. The Global Burden of Disease study methodology was used to estimate the burden of alcohol-attributable liver cirrhosis and alcohol-attributable liver cancer in 2010 as measured by deaths and disability adjusted life years (DALYs). This methodology estimates attributable fractions based on alcohol exposure distribution and relative risks associated with different levels of drinking. Globally, in 2010, alcohol-attributable liver cirrhosis was responsible for 493,300 deaths (156,900 female deaths and 336,400 male deaths) and 14,544,000 DALYs (4,112,000 DALYs for women and 10,432,000 DALYs for men), representing 0.9% (0.7% for women and 1.2% for men) of all global deaths and 0.6% (0.4% for women and 0.8% for men) of all global DALYs, and 47.9% of all liver cirrhosis deaths (46.5% for women and 48.5% for men) and 46.9% of all liver cirrhosis DALYs (44.5% for women and 47.9% for men). Alcohol-attributable liver cancer was responsible for 80,600 deaths (14,800 female deaths and 65,900 male deaths) and 2,142,000 DALYs (335,000 DALYs for women and 1,807,000 DALYs for men). The burden of alcohol-attributable liver cirrhosis and liver cancer is high and entirely preventable. Interventions to reduce alcohol consumption are recommended as a population health priority and may range from taxation increases for alcoholic beverages to increases in screening and treatment rates for alcohol use disorders.

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  • Liver disease is linked clearly to alcohol.

    “Liver disease is linked clearly to alcohol 277, evidenced by several ICD codes for alcoholic liver diseases (Table 1), including simple alcoholic steatosis, hepatitis, fibrosis and cirrhosis and superimposed hepatocellular carcinoma, which is part of alcohol‐attributable cancers (see above).”

    From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [277]

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Authors
Rehm, J., Samokhvalov, A. V., & Shield, K. D.
Affiliations
Centre for Addiction and Mental Health (CA)
ORCID
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2013-07
Volume
59
Issue
1
Pages
160-168
ISSN
0168-8278 (ISSN-L)
DOI
10.1016/j.jhep.2013.03.007
OpenAlex
W2048180954
Cited by
740
References
59
Citations by year
2026: 25 · 2025: 47 · 2024: 42 · 2023: 53 · 2022: 67 · 2021: 61 · 2020: 89 · 2019: 76 · 2018: 74 · 2017: 73 · 2016: 50 · 2015: 55 · 2014: 23 · 2013: 4
FWCI
6.45
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Hepatology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Ontario Ministry of Health and Long-Term Care
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Business, Management and Accounting › Organizational Behavior and Human Resource Management › Global Public Health Policies and Epidemiology
Keywords
alcoholic liver disease, liver cirrhosis, liver cancer, disability-adjusted life years, alcohol consumption, attributable fraction, alcohol taxation, global burden of disease
MeSH terms
Alcohol Drinking, Female, Humans, Liver Cirrhosis, Alcoholic, Liver Diseases, Alcoholic, Liver Neoplasms, Male, Risk Factors, Sex Factors, Global Health, Quality-Adjusted Life Years

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