Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion
Open accessAbstract
Background. Prior studies suggest that renin-angiotensin-aldosterone system (RAAS) inhibitors decrease parathyroid hormone (PTH) secretion. Objective. To evaluate the effect of angiotensin-converting enzyme inhibitors (ACEi) on serum PTH in participants with and without primary hyperparathyroidism (P-HPT). Methods. An open-label, single-arm, pilot study whereby participants with and without P-HPT had PTH were evaluated before and after 1 week of maximally tolerated lisinopril therapy. Results. A total of 12 participants with, and 15 participants without, P-HPT successfully completed the protocol. Following 1 week of lisinopril, participants with P-HPT had a decrease in systolic blood pressure (SBP) (−6.4 mmHg, P<0.01), an increase in plasma renin activity (PRA) (+1.50 ng/mL/h, P=0.06), and a decrease in PTH (79.5 (21.6) to 70.9 (19.6) pg/mL, ∆=−8.6 pg/mL, P=0.049); however, serum and urine calcium did not change. In contrast, although 1 week of lisinopril significantly decreased SBP and increased PRA among participants without P-HPT, there were no changes in PTH or calcium. Conclusion. In this short pilot investigation, 1 week of maximally titrated ACEi did not impact PTH in participants without P-HPT, but resulted in a modest and marginally significant reduction of PTH but not calcium, among participants with P-HPT. This trial is registered with ClinicalTrials.gov NCT01691781.
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“В когорте пациентов с ПГПТ получены противоречивые результаты в отношении изменения концентрации параметров РААС, а также уровня ПТГ при приеме препаратов, влияющих на активность данной системы регуляции АД [22, 23].”
- Authors
- Zaheer, S., Brown, J. M., Connors, M., Williams, J. S., Adler, G. K., & Vaidya, A.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Zaheer, Sarah
- Vaidya, Anand
- Venue
- International Journal of Endocrinology
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-8
- ISSN
- 1687-8337 (ISSN-L)
- 1687-8345
- PMC
- PMC5541811
- OpenAlex
- W2737314641
- Cited by
- 12
- References
- 36
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2020: 5 · 2019: 1 · 2018: 1 · 2017: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Heart, Lung, and Blood Institute (2015085, K24 HL103845, K23 HL111771, R01 DK107407)
- Doris Duke Charitable Foundation (2015085, K24 HL103845, K23 HL111771, R01 DK107407)
- National Institutes of Diabetes and Digestive and Kidney Disease of the National Institutes of Health (2015085, K24 HL103845, K23 HL111771, R01 DK107407)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- ACE inhibitors, parathyroid hormone secretion, primary hyperparathyroidism, lisinopril, renin-angiotensin-aldosterone system, plasma renin activity, blood pressure, serum calcium, urinary calcium
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