Hyperparathyroidism in Patients with Primary Aldosteronism: Cross-Sectional and Interventional Data from the GECOH Study
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Context: Experimental studies suggest that aldosterone induces hypercalciuria and might contribute to hyperparathyroidism. Objective: We aimed to test for differences in PTH levels and parameters of calcium and vitamin D metabolism in patients with primary aldosteronism (PA) compared with patients with essential hypertension (EH) and to evaluate the impact of PA treatment on these laboratory values. Design, Setting, and Participants: The Graz Endocrine Causes of Hypertension study includes hypertensive patients referred for screening for endocrine hypertension at a tertiary care center in Graz, Austria. Main Outcome Measures: Differences in PTH levels between patients with PA and EH. Results: Among 192 patients, we identified 10 patients with PA and 182 with EH. PTH levels (mean ± sd in picograms per milliliter) were significantly higher in PA patients compared with EH (67.8 ± 26.9 vs. 46.5 ± 20.9; P = 0.002). After treatment of PA with either adrenal surgery (n = 5) or mineralocorticoid receptor antagonists (n = 5), PTH concentrations decreased to 43.9 ± 14.9 (P = 0.023). Serum 25-hydroxyvitamin D concentrations were similar in both groups. Compared with EH, serum calcium concentrations were significantly lower (2.35 ± 0.10 vs. 2.26 ± 0.10 mmol/liter; P = 0.013), and there was a nonsignificant trend toward an increased spot urine calcium to creatinine ratio in PA [median (interquartile range) 0.19 (0.11–0.31) vs. 0.33 (0.12–0.53); P = 0.094]. Conclusions: Our results suggest that PA contributes to secondary hyperparathyroidism. Further studies are warranted to evaluate whether PTH has implications for PA diagnostics and whether mineralocorticoid receptor antagonists have a general impact on PTH and calcium metabolism.
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Prior research has shown that chronic aldosterone excess results in hypercalciuria and hypocalcemia.
“Although we did not have urine calcium measurements in this study, prior research has shown that chronic aldosterone excess results in hypercalciuria and hypocalcemia16,38,39.”
From Human Interventions to Characterize Novel Relationships Between the Renin–Angiotensin–Aldosterone System and Parathyroid Hormone (2014) · cites this paper as [16]
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Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism
Milliez, P., Girerd, X. J., Plouin, P., Blacher, J., Safar, M. E., & Mourad, J. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.01.015 · Cited by 1,541 · see citing works
Plasma Parathyroid Hormone and the Risk of Cardiovascular Mortality in the Community
Hagström, E., Hellman, P., Larsson, T. E., Ingelsson, E., Berglund, L., Sundström, J., Melhus, H., Held, C., Lind, L., Michaëlsson, K., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.808733 · Cited by 416 · see citing works
Hyperparathyroidism and the Calcium Paradox of Aldosteronism
Chhokar, V. S., Sun, Y., Bhattacharya, S. K., Ahokas, R. A., Myers, L. K., Xing, Z., Smith, R. A., Gerling, I., & Weber, K. T. (2005) · Circulation · doi:10.1161/01.cir.0000155621.10213.06 · Cited by 208 · see citing works
Pilz, S., Tomaschitz, A., Drechsler, C., Ritz, E., Boehm, B. O., Grammer, T. B., & Marz, W. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq109 · Cited by 160 · see citing works
Self-citationRossi, E., Sani, C., Perazzoli, F., Casoli, M. C., Negro, A., & Dotti, C. (1995) · American Journal of Hypertension · doi:10.1016/0895-7061(95)00182-o · Cited by 134 · see citing works
Calcium metabolism and parathyroid function in primary aldosteronism
Resnick, L. M., & Laragh, J. H. (1985) · The American Journal of Medicine · doi:10.1016/0002-9343(85)90328-6 · Cited by 111 · see citing works
Calcium paradox of aldosteronism and the role of the parathyroid glands
Vidal, A., Sun, Y., Bhattacharya, S. K., Ahokas, R. A., Gerling, I., & Weber, K. T. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00535.2005 · Cited by 94 · see citing works
Gennari, C., Nami, R., & Gonnelli, S. (1995) · PubMed · Cited by 86 · see citing works
Brunaud, L., Germain, A., Zarnegar, R., Rancier, M., Alrasheedi, S., Caillard, C., Ayav, A., Weryha, G., Mirallie, E., & Bresler, L. (2009) · Surgery · doi:10.1016/j.surg.2009.09.041 · Cited by 83 · see citing works
Effect of chronic mineralocorticoid administration on calcium excretion in the rat
Suki, W., Schwettmann, R., Rector, F. C., & Dw, S. (1968) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1968.215.1.71 · Cited by 83 · see citing works
Fracture Risk in Men With Congestive Heart Failure
Carbone, L. D., Cross, J. D., Raza, S. H., Bush, A. J., Sepanski, R. J., Dhawan, S., Khan, B. Q., Gupta, M., Ahmad, K., Khouzam, R. N., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.03.039 · Cited by 79 · see citing works
Diuretics and Bone Loss in Rats With Aldosteronism
Law, P., Sun, Y., Bhattacharya, S. K., Chhokar, V. S., & Weber, K. T. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.03.055 · Cited by 72 · see citing works
Kovacs, L., Goth, M., Szabolcs, I., Dohan, O., Ferencz, A., & Szilagyi, G. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1380543 · Cited by 66 · see citing works
Hypercalcemia in Addison's disease: calciotropic hormone profile and bone histology
Montoli, A., Colussi, G., & MINETTI, L. (1992) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1992.tb00636.x · Cited by 57 · see citing works
Secondary Hyperparathyroidism in Patients with Untreated and Treated Congestive Heart Failure
Khouzam, R. N., Weber, K. T., Flax, S. D., Dishmon, D. A., Farah, V., & Carbone, L. D. (2006) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200601000-00009 · Cited by 54 · see citing works
Renin-angiotensin-aldosterone system in primary hyperparathyroidism before and after surgery
Bernini, G., Moretti, A., Lonzi, S., Bendinelli, C., Miccoli, P., & Salvetti, A. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90075-6 · Cited by 40 · see citing works
Bone Loss in Rats with Aldosteronism
Runyan, A. L., Chhokar, V. S., Sun, Y., Weber, K. T., Runyan, J. W., & Bhattacharya, S. K. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200507000-00001 · Cited by 36 · see citing works
Enhancement of the stimulatory effect of calcium on aldosterone secretion by parathyroid hormone.
Ølgaard, K., Lewin, E., Bro, S., Daugaard, H., Egfjord, M., & Pless, V. (1994) · PubMed · Cited by 34 · see citing works
Pilz, S., Tomaschitz, A., Stepan, V. M., Obermayer-Pietsch, B. M., Fahrleitner‐Pammer, A., Schweighofer, N., Portugaller, H. R., Sourij, H., Dobnig, H., Meinitzer, A., et al. (2009) · BMC Endocrine Disorders · doi:10.1186/1472-6823-9-11 · Cited by 27 · see citing works
Self-citationPrimary Hyperparathyroidism: Possible Cause of Primary Hyperaldosteronism in a 60-Year-Old Woman*
Barkan, A., Marilus, R., Winkelsberg, G., Yeshurun, D., & Blum, I. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-1-144 · Cited by 27 · see citing works
Aldosterone and Parathyroid Hormone: A Complex and Clinically Relevant Relationship
Pilz, S., Tomaschitz, A., März, W., Cavalier, E., & Ritz, E. (2010) · Calcified Tissue International · doi:10.1007/s00223-010-9409-5 · Cited by 21 · see citing works
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Tomaschitz, A., Ritz, E., Pieske, B. M., Rus-Machan, J., Kienreich, K., Verheyen, N., Gaksch, M., Grübler, M. R., Fahrleitner‐Pammer, A., Mrak, P., et al. (2013) · Metabolism · doi:10.1016/j.metabol.2013.08.016 · Cited by 167 · see citing works
Self-citationStowasser, M., & Gordon, R. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00026.2015 · Cited by 159 · see citing works
Rossi, G. P., Bisogni, V., Bacca, A., Belfiore, A., Cesari, M., Concistrè, A., Pinto, R. D., Fabris, B., Fallo, F., Fava, C., et al. (2020) · International Journal of Cardiology Hypertension · doi:10.1016/j.ijchy.2020.100029 · Cited by 139 · see citing works
Aldosterone and parathyroid hormone: a precarious couple for cardiovascular disease
Tomaschitz, A., Ritz, E., Pieske, B. M., Fahrleitner‐Pammer, A., Kienreich, K., Horina, J. H., Drechsler, C., März, W., Ofner, M., Pieber, T. R., et al. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs092 · Cited by 129 · see citing works
Self-citationBone involvement in aldosteronism
Salcuni, A. S., Palmieri, S., Carnevale, V., Morelli, V., Battista, C., Guarnieri, V., Guglielmi, G., Desina, G., Eller-Vainicher, C., Beck-Peccoz, P., et al. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1660 · Cited by 101 · see citing works
The renin–angiotensin–aldosterone system and calcium-regulatory hormones
Vaidya, A., Brown, J. M., & Williams, J. S. (2015) · Journal of Human Hypertension · doi:10.1038/jhh.2014.125 · Cited by 93 · see citing works
Brown, J. M., Williams, J. S., Luther, J. M., Garg, R., Garza, A. E., Pojoga, L. H., Ruan, D. T., Williams, G. H., Adler, G. K., & Vaidya, A. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.01910 · Cited by 88 · see citing works
Bone health and aldosterone excess
Ceccoli, L., Ronconi, V., Giovannini, L., Marcheggiani, M., Turchi, F., Boscaro, M., & Giacchetti, G. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2399-1 · Cited by 85 · see citing works
Rossi, G. P., Ragazzo, F., Seccia, T. M., Maniero, C., Barisa, M., Calò, L. A., Frigo, A. C., Fassina, A., & Pessina, A. C. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.195891 · Cited by 76 · see citing works
Touvier, M., Deschasaux, M., Montourcy, M., Sutton, A., Charnaux, N., Kesse‐Guyot, E., Fezeu, L., Latino‐Martel, P., Druesne‐Pecollo, N., Malvy, D. J.-M., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3349 · Cited by 72 · see citing works
Brown, J., de Boer, I. H., Robinson-Cohen, C., Siscovick, D. S., Kestenbaum, B., Allison, M., & Vaidya, A. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3949 · Cited by 71 · see citing works
Vaidya, A., Sun, B., Larson, C., Forman, J. P., & Williams, J. S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1156 · Cited by 68 · see citing works
Bone and Mineral Metabolism in Patients with Primary Aldosteronism
Petramala, L., Zinnamosca, L., Settevendemmie, A., Marinelli, C., Nardi, M., Concistrè, A., Corpaci, F., Tonnarini, G., Toma, G. D., & Letizia, C. (2014) · International Journal of Endocrinology · doi:10.1155/2014/836529 · Cited by 65 · see citing works
The Interplay Between the Renin-Angiotensin-Aldosterone System and Parathyroid Hormone
Zheng, M.-H., Li, F., Xu, F., Lin, X., Wang, Y., Xu, Q.-S., Guo, B., & Yuan, L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00539 · Cited by 67 · see citing works
Mineral metabolism and cardiovascular disease in CKD
Fujii, H., & Joki, N. (2017) · Clinical and Experimental Nephrology · doi:10.1007/s10157-016-1363-8 · Cited by 60 · see citing works
Rossitto, G., Regolisti, G., Rossi, E., Negro, A., Nicoli, D., Casali, B., Toniato, A., Caroccia, B., Seccia, T. M., Walther, T., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.202945 · Cited by 60 · see citing works
Primary aldosteronism as a cause of secondary osteoporosis
Salcuni, A. S., Carnevale, V., Battista, C., Palmieri, S., Eller-Vainicher, C., Guarnieri, V., Pugliese, F., Guglielmi, G., Desina, G., Minisola, S., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0417 · Cited by 49 · see citing works
Fernández-Argüeso, M., Corrales, E. P., Rojano, N. B., Cano, A. M. G., Mendiguchía, L. J., & Castro, M. A. (2021) · Endocrine · doi:10.1007/s12020-021-02704-2 · Cited by 43 · see citing works
Kim, B., Kwak, M. K., Ahn, S. H., Kim, H., Lee, S. H., & Koh, J. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02043 · Cited by 41 · see citing works
Primary Aldosteronism and Bone Metabolism: A Systematic Review and Meta-Analysis
Shi, S., Lu, C., Tian, H., Ren, Y., & Chen, T. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.574151 · Cited by 39 · see citing works
Interactions between adrenal-regulatory and calcium-regulatory hormones in human health
Brown, J. M., & Vaidya, A. (2014) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000062 · Cited by 39 · see citing works
Association between Parathyroid Hormone and Cardiovascular Disease
Fujii, H. (2018) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.12679 · Cited by 39 · see citing works
Fischer, E., Hannemann, A., Rettig, R., Lieb, W., Nauck, M., Pallauf, A., Bildingmaier, M., Beuschlein, F., Wallaschofski, H., & Reincke, M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3214 · Cited by 37 · see citing works
Lenzini, L., Prisco, S., Vanderriele, P. E., Lerco, S., Torresan, F., Maiolino, G., Seccia, T. M., Iacobone, M., & Rossi, G. P. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00143 · Cited by 33 · see citing works
The molecular basis of primary aldosteronism: from chimeric gene to channelopathy
Lenzini, L., & Rossi, G. P. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.12.005 · Cited by 31 · see citing works
Hypertension, Antihypertensive Medications, and Risk of Incident Primary Hyperparathyroidism
Vaidya, A., Curhan, G. C., Paik, J. M., Kronenberg, H. M., & Taylor, E. N. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1619 · Cited by 29 · see citing works
Interrelated aldosterone and parathyroid hormone mutually modify cardiovascular mortality risk
Tomaschitz, A., Pilz, S., Rus-Machan, J., Meinitzer, A., Brandenburg, V. M., Scharnagl, H., Kapl, M., Grammer, T., Ritz, E., Horina, J. H., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.062 · Cited by 27 · see citing works
Self-citationBayomy, O. F., Zaheer, S., Williams, J. S., Curhan, G. C., & Vaidya, A. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa123 · Cited by 27 · see citing works
Tomaschitz, A., Fahrleitner‐Pammer, A., Pieske, B. M., Verheyen, N., Amrein, K., Ritz, E., Kienreich, K., Horina, J. H., Schmidt, A. G., Kraigher‐Krainer, E., et al. (2012) · BMC Endocrine Disorders · doi:10.1186/1472-6823-12-19 · Cited by 26 · see citing works
Self-citationAsbach, E., Bekeran, M., König, A., Lang, K., Hanslik, G., Treitl, M., Ladurner, R., Bidlingmaier, M., Beuschlein, F., Quinkler, M., et al. (2020) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1027-6472 · Cited by 25 · see citing works
Song, S., Cai, X., Hu, J., Zhu, Q., Shen, D., Ma, H., Zhang, Y., Ma, R., Yang, W., Hong, J., et al. (2024) · Drug Design, Development and Therapy · doi:10.2147/dddt.s466904 · Cited by 25 · see citing works
Tomaschitz, A., Piecha, G., Ritz, E., Meinitzer, A., Haas, J. G., Pieske, B. M., Więcek, A., Rus-Machan, J., Toplak, H., März, W., et al. (2014) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2014.913604 · Cited by 25 · see citing works
Self-citationTomaschitz, A., Verheyen, N., Meinitzer, A., Pieske, B., Belyavskiy, E., Brussee, H., Haas, J., März, W., Pieske-Kraigher, E., Verheyen, S., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000000927 · Cited by 24 · see citing works
Self-citationVerheyen, N., Fahrleitner-Pammer, A., Pieske, B., Meinitzer, A., Belyavskiy, E., Wetzel, J., Gaksch, M., Grübler, M. R., Catena, C., Sechi, L. A., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001004 · Cited by 24 · see citing works
Self-citationParathyroid Gland Function in Primary Aldosteronism
Bekeran, M., Reincke, M., & Asbach, E. (2015) · Hormone and Metabolic Research · doi:10.1055/s-0035-1565224 · Cited by 22 · see citing works
The Endocrine Role of Bone in Cardiometabolic Health
DeLuccia, R., Cheung, M. M., Ramadoss, R. K., Aljahdali, A., & Sukumar, D. (2019) · Current Nutrition Reports · doi:10.1007/s13668-019-00286-0 · Cited by 20 · see citing works
Factors affecting parathyroid hormone levels in different types of primary aldosteronism
Jiang, Y., Zhang, C., Ye, L., Su, T., Zhou, W., Jiang, L., Zhang, Y., & Wang, W. (2015) · Clinical Endocrinology · doi:10.1111/cen.12981 · Cited by 20 · see citing works
Acute and long-term kidney function after parathyroidectomy for primary hyperparathyroidism
Belli, M., Martin, R. M., Brescia, M. D. G., do Nascimento, C. P., Neto, L. M. M., Arap, S., Ferraz‐de‐Souza, B., Moysés, R. M. A., Peacock, M., & Montenegro, F. L. D. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244162 · Cited by 18 · see citing works
Loh, H. H., & Sukor, N. (2019) · Journal of Human Hypertension · doi:10.1038/s41371-019-0294-8 · Cited by 19 · see citing works
Tuersun, T., Luo, Q., Zhang, Z., Wang, G., Zhang, D., Wang, M., Wu, T., Zhou, K., Yue, N., & Li, N. (2020) · Hypertension Research · doi:10.1038/s41440-020-0529-7 · Cited by 18 · see citing works
Wang, A., Wang, Y., Liu, H., Hu, X., Li, J., Xu, H., Nie, Z., Zhang, L., & Lyu, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1027841 · Cited by 19 · see citing works
Adrenal disorders: Is there Any role for vitamin D?
Tirabassi, G., Salvio, G., Altieri, B., Ronchi, C. L., Casa, S. D., Pontecorvi, A., & Balercia, G. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9391-y · Cited by 18 · see citing works
Interplay Between Sodium and Calcium Regulatory Hormones
Tomaschitz, A., & Pilz, S. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02253 · Cited by 18 · see citing works
Self-citationThe effect of vitamin D treatment on clinical and biochemical outcomes of primary aldosteronism
Ismail, N. A., Kamaruddin, N. A., Shah, S. A., & Sukor, N. (2020) · Clinical Endocrinology · doi:10.1111/cen.14177 · Cited by 17 · see citing works
Bone Health in Adrenal Disorders
Kim, B., Lee, S. H., & Koh, J. (2018) · Endocrinology and Metabolism · doi:10.3803/enm.2018.33.1.1 · Cited by 17 · see citing works
Adrenocortical incidentalomas and bone: from molecular insights to clinical perspectives
Altieri, B., Muscogiuri, G., Paschou, S. Α., Vryonidou, A., Casa, S. D., Pontecorvi, A., Faßnacht, M., Ronchi, C. L., & Newell-Price, J. D. C. (2018) · Endocrine · doi:10.1007/s12020-018-1696-z · Cited by 16 · see citing works
Hassan, M., Qureshi, W., Sroujieh, L. S., Albashaireh, D., BouMalham, S., Liroff, M., Amjad, W., Khalid, F., Hadid, H., & Alirhayim, Z. (2014) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320314539180 · Cited by 15 · see citing works
Lin, W., Gan, W., Feng, P., Zhong, L., Yao, Z., Chen, P., He, W., & Yu, N. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.882148 · Cited by 14 · see citing works
Pilz, S., Kienreich, K., Stückler, D., Meinitzer, A., & Tomaschitz, A. (2012) · International Journal of Endocrinology · doi:10.1155/2012/732636 · Cited by 14 · see citing works
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Pilz, S., Keppel, M. H., Trummer, C., Theiler‐Schwetz, V., Pandis, M., Borzan, V., Pittrof, M., Obermayer-Pietsch, B. M., Grübler, M. R., Verheyen, N., et al. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00145 · Cited by 14 · see citing works
Self-citationPilz, S., Trummer, C., Verheyen, N., Theiler‐Schwetz, V., Pandis, M., Aberer, F., Grübler, M. R., Meinitzer, A., Bachmann, A., Voelkl, J. G. J., et al. (2018) · Hormone and Metabolic Research · doi:10.1055/a-0604-3249 · Cited by 13 · see citing works
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Zaheer, S., Brown, J. M., Connors, M., Williams, J. S., Adler, G. K., & Vaidya, A. (2017) · International Journal of Endocrinology · doi:10.1155/2017/4138783 · Cited by 12 · see citing works
Vaidya, A., UNDERWOOD, P. C., Annes, J. P., Sun, B., Williams, G. H., Forman, J. P., & Williams, J. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.10.001 · Cited by 11 · see citing works
Secondary Hypertension Due To Concomitant Aldosterone-Producing Adenoma and Parathyroid Adenoma
Chau, K., Holmes, D. T., Melck, A. L., & Chan-Yan, C. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu102 · Cited by 11 · see citing works
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Refaie, A. F. A., Baldassini, L., Vita, M. D., Gonnelli, S., & Caffarelli, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1001065 · Cited by 11 · see citing works
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Loh, H. H., Yee, A. H. A., & Loh, H. S. (2020) · Minerva Endocrinology · doi:10.23736/s0391-1977.18.02867-5 · Cited by 11 · see citing works
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Kono, K., Fujii, H., Watanabe, K., Goto, S., & Nishi, S. (2020) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01139-5 · Cited by 10 · see citing works
Risk Factors Associated With Lower Bone Mineral Density in Primary Aldosteronism Patients
Lv, X., Hu, H., Shen, C., Zhang, X., Yan, L., Zhang, S., & Guo, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.884302 · Cited by 10 · see citing works
Concistrè, A., Petramala, L., Zinnamosca, L., Settevendemmie, A., Corpaci, F., Marinelli, C., Tonnarini, G., D’Ermo, G., Toma, G. D., & Letizia, C. (2015) · PubMed · Cited by 10 · see citing works
Zavatta, G., Dalmazi, G. D., Altieri, P., Pelusi, C., Golfieri, R., Mosconi, C., Balacchi, C., Borghi, C., Cosentino, E. R., Cintio, I. D., et al. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2021.09.002 · Cited by 11 · see citing works
PTH Is a Promising Auxiliary Index for the Clinical Diagnosis of Aldosterone-Producing Adenoma
Zhang, L., Gu, W., Li, Y., Wang, Y., Wang, W., Wang, A., Shen, L., Zang, L., Yang, G., Lü, Z., et al. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv146 · Cited by 10 · see citing works
Maranducă, M. A., Cozma, C. T., Clim, A., Pînzariu, A. C., Tudorancea, I., Popa, I. P., Lazăr, C. I., Moscalu, R., Filip, N., Moscalu, M., et al. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46050241 · Cited by 8 · see citing works
Stanić, B. M., Ilinčić, B., Žeravica, R., Ivanovski, D. M., Čabarkapa, V., & Mijović, R. (2022) · International Journal of Endocrinology · doi:10.1155/2022/3804899 · Cited by 8 · see citing works
Keppel, M. H., Piecha, G., März, W., Cadamuro, J., Auer, S., Felder, T. K., Mrazek, C., Oberkofler, H., Trummer, C., Grübler, M. R., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212973 · Cited by 8 · see citing works
Self-citationPetramala, L., Savoriti, C., Zinnamosca, L., Marinelli, C., Settevendemmie, A., Calvieri, C., Catani, M., & Letizia, C. (2013) · Internal Medicine · doi:10.2169/internalmedicine.52.8794 · Cited by 8 · see citing works
Primary aldosteronism 2.0: an update for clinicians on diagnosis and treatment
Pilz, S., Kocjan, T., Theiler‐Schwetz, V., & Trummer, C. (2023) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.16585 · Cited by 7 · see citing works
Self-citationAssociation of serum parathyrine and calcium levels with primary aldosteronism: a meta-analysis.
Zhang, Y., & Feng, B. (2015) · PubMed · Cited by 7 · see citing works
Disease monitoring of Primary Aldosteronism
Rossi, G. P., Cesari, M., Lenzini, L., & Seccia, T. M. (2020) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2020.101417 · Cited by 7 · see citing works
Primary Aldosteronism with Parathyroid Hormone Elevation: A Single-center Retrospective Study
Kometani, M., Yoneda, T., Aono, D., Noda, Y., Matsuoka, T., Higashitani, T., Yoshikura, S., Sawada, K. B., Takeda, Y., Fujimoto, A., et al. (2021) · Internal Medicine · doi:10.2169/internalmedicine.5282-20 · Cited by 7 · see citing works
Hibi, Y., Hayakawa, N., Hasegawa, M., Ogawa, K., Shimizu, Y., Shibata, M., Kagawa, C., Mizuno, Y., Yuzawa, Y., Itoh, M., et al. (2013) · Surgery Today · doi:10.1007/s00595-013-0813-0 · Cited by 7 · see citing works
Bislev, L. S., Sikjær, T., Rolighed, L., & Rejnmark, L. (2015) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-015-9182-0 · Cited by 8 · see citing works
Connecting the dots: renin-angiotensin-aldosterone system, vitamin D, and hypertension
Loh, H. H., Azizan, E. A., & Sukor, N. (2025) · Journal of Hypertension · doi:10.1097/hjh.0000000000004046 · Cited by 6 · see citing works
Trandafir, A.-I., Gheorghe, A.-M., Sima, O.-C., Ciuche, A., Petrova, E. N., Nistor, C., & Carşote, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417338 · Cited by 6 · see citing works
Saline suppression testing-induced hypocalcemia and implications for clinical interpretations
Parksook, W. W., Brown, J. M., Milks, J., Tsai, L. C., Chan, J., Moore, A., Niebuhr, Y., Honzel, B., Newman, A. J., & Vaidya, A. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae099 · Cited by 6 · see citing works
Changes in PTH Across the Spectrum of Renin-independent Aldosteronism
Ooi, A., Khan, H., Akram, M., Fuller, P. J., Milat, F., Yang, J., & Libianto, R. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf151 · Cited by 6 · see citing works
Taiwan mini-frontier of primary aldosteronism: Updating treatment and comorbidities detection
Chan, C., Chang, Y., Tsai, Y., Chen, Z., Wu, C.-Y., Huang, W., Yen, I., Wu, K.-H., Wu, V., Lin, Y., et al. (2021) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2021.03.032 · Cited by 6 · see citing works
Zhang, W., Wang, Y., Wei, Z. C., Chang, G., Luo, Q., Abudusailamu, N., Nurula, M., Tao, S., Li, H., & Chen, Y. (2019) · Springer eBooks · doi:10.1007/978-981-15-0591-1_9 · Cited by 5 · see citing works
Hyperparathyroidism in patients with overt and mild primary aldosteronism
Gravvanis, C., Papanastasiou, L., Glycofridi, S., Voulgaris, N., Tyfoxylou, E., Kounadi, T., Piaditis, G. P., & Markou, Α. (2021) · HORMONES · doi:10.1007/s42000-021-00319-w · Cited by 5 · see citing works
Aldosterone Secretion in Patients With Primary Hyperparathyroidism Without Arterial Hypertension
Castellano, E., Pellegrino, M., Tardivo, V., Attanasio, R., Boriano, A., & Borretta, G. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2021.04.886 · Cited by 4 · see citing works
Primärer Hyperaldosteronismus: Diagnostik und Therapie
Pilz, S., Tomaschitz, A., Trummer, C., Bachmann, A., Pandis, M., Theiler‐Schwetz, V., Obermayer-Pietsch, B. M., & März, W. (2017) · Journal für Klinische Endokrinologie und Stoffwechsel · doi:10.1007/s41969-017-0010-7 · Cited by 4 · see citing works
Self-citationPrimary aldosteronism — recent progress and current concepts
Kołodziejczyk‐Kruk, S., Januszewicź, W., Pęczkowska, M., Prejbisz, A., Zgliczyński, W., & Januszewicz, A. (2013) · Endokrynologia Polska · doi:10.5603/ep.2013.0011 · Cited by 3 · see citing works
Impact of Endocrine Disorders on Blood Pressure
Carbone, F., Bonaventura, A., Vecchié, A., Casula, M., Liberale, L., Dallegri, F., & Montecucco, F. (2020) · Endocrinology · doi:10.1007/978-3-319-68729-2_2 · Cited by 3 · see citing works
Systematic approach to the diagnosis and management of endocrine hypertension
Stowasser, M., Jansen, P. M., & Wolley, M. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-96120-2.00009-1 · Cited by 4 · see citing works
Aldosterone and Parathyroid Hormone: Evidence for a Clinically Relevant Relationship
Naik, V. (2019) · Journal of Endocrinology and Thyroid Research · doi:10.19080/jetr.2019.04.555637 · Cited by 3 · see citing works
A case of primary aldosteronism with secondary hyperparathyroidism and bilateral adrenal tumors
Eguchi, T., & Miyauchi, S. (2015) · Endocrinology Diabetes and Metabolism Case Reports · doi:10.1530/edm-15-0029 · Cited by 2 · see citing works
Double hit! A unique case of resistant hypertension
DeCarlo, K., & Agrawal, N. (2017) · BMJ Case Reports · doi:10.1136/bcr-2017-221530 · Cited by 2 · see citing works
Tang, W., Chai, Y., Jia, H., Wang, B., Liu, T., Wang, H., & Dai, C. (2022) · BMC Endocrine Disorders · doi:10.1186/s12902-022-00955-2 · Cited by 2 · see citing works
Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism
Lim, J. S., Hong, N., Park, S., Park, S. I., Oh, Y. T., Yu, M. H., Lim, P. Y., & Rhee, Y. (2018) · Endocrinology and Metabolism · doi:10.3803/enm.2018.33.4.485 · Cited by 2 · see citing works
Clinical-Pathological Conference Series from the Medical University of Graz
Fabian, E., Schneeweiß, B., Valentin, T., Flick, H., Aigelsreiter, A., Hofmann‐Wellenhof, R., Cerroni, L., Goritschan, A., Brezinsek, H. P., Zitta, S., et al. (2017) · Wiener klinische Wochenschrift · doi:10.1007/s00508-016-1164-9 · Cited by 2 · see citing works
Fernández-Sánchez, Á., Meneses, D., Bellassai, E. R. A., Cárdenas‐Salas, J., Paniagua, A., Vázquez, C., & Ruiz-Sánchez, J. G. (2025) · Endocrines · doi:10.3390/endocrines6010008 · Cited by 1 · see citing works
Primärer Hyperaldosteronismus – Guideline der Endocrine Society 2025
Pilz, S., Schmitt, L., Kraus, D. A., Theiler‐Schwetz, V., Trummer, C., & Riedmann, U. (2025) · Journal für Endokrinologie Diabetologie und Stoffwechsel · doi:10.1007/s41969-025-00291-5 · Cited by 1 · see citing works
Self-citationMediastinal Parathyroidectomy: Preoperative Management of Hyperparathyroidism
Sagan, D., Jerzy, S., Nowakowski, A. M., Klatka, M., Czekajska−Chehab, E., Drop, A., Chrapko, B. E., & Klatk, J. (2012) · InTech eBooks · doi:10.5772/38188 · Cited by 1 · see citing works
Clinical-Pathological Conference Series from the Medical University of Graz
Fabian, E., Schiller, D., Tomaschitz, A., Langner, C., Pilz, S., Quasthoff, S., Raggam, R. B., Schoefl, R., & Krejs, G. J. (2016) · Wiener klinische Wochenschrift · doi:10.1007/s00508-016-1085-7 · Cited by 1 · see citing works
Self-citationPrimary aldosteronism complicated by hyperparathyroidism: report of one case and literature review.
Zhou, D.-D., Liu, M., & Yan, Z. (2019) · Europe PMC (PubMed Central) · Cited by 1 · see citing works
Parksook, W. W., Heydarpour, M., Brown, J. M., Turchin, A., Mannstadt, M., & Vaidya, A. (2022) · Clinical Endocrinology · doi:10.1111/cen.14840 · Cited by 1 · see citing works
Research progress on the correlation between primary aldosteronism and bone metabolism
Chai, Y. (2022) · Frontiers in Medical Science Research · doi:10.25236/fmsr.2022.041308 · Cited by 1 · see citing works
Castro, M. A., Corrales, E. P., Fernández-Argüeso, M., BENGOA-ROJANO, N., Cano, A. M. G., Mendiguchía, L. J., & Cuesta, M. (2023) · Minerva Endocrinology · doi:10.23736/s2724-6507.23.03866-6 · Cited by 1 · see citing works
Aldosterone and Cardiovascular Diseases
Tomaschitz, A., & Pilz, S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0509-6_12
Self-citationDie Rolle von Aldosteron im Knochenstoffwechsel
Tomaschitz, A., Kienreich, K., Fahrleitner‐Pammer, A., & Pilz, S. (2012) · Journal für Kardiologie (Krause & Pachernegg GmbH)
Self-citation
- Authors
- Pilz, S., Kienreich, K., Drechsler, C., Ritz, E., Fahrleitner-Pammer, A., Gaksch, M., Meinitzer, A., März, W., Pieber, T. R., & Tomaschitz, A.
- Affiliations
- Amsterdam Public Health (NL)
- Department of Internal Medicine (S.P., K.K., A.F.-P., M.G., T.R.P., A.T.), 8036 Graz, Austria
- University of Würzburg (DE)
- University Hospital Heidelberg (DE)
- Medical University of Graz (AT)
- Corresponding author
- Pilz, Stefan
- Tomaschitz, Andreas
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2012-01-01
- Volume
- 97
- Issue
- 1
- Pages
- E75-E79
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2074546237
- Cited by
- 118
- References
- 21
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 14 · 2019: 10 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 10 · 2014: 9 · 2013: 8 · 2012: 11
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Austrian Federal Ministry of Economy, Family and Youth
- Oesterreichische Nationalbank (13905, 825329)
- Bundesministerium für Verkehr, Innovation und Technologie
- Steirische Wirtschaftsförderungsgesellschaft
- Karl-Franzens-Universität Graz
- Medizinische Universität Graz
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
- Keywords
- primary aldosteronism, secondary hyperparathyroidism, parathyroid hormone, essential hypertension, mineralocorticoid receptor antagonists, adrenal surgery, hypercalciuria, vitamin D metabolism, serum calcium, endocrine hypertension
- MeSH terms
- Adult, Aged, Aldosterone, Blood Pressure, Clinical Trials as Topic, Cross-Sectional Studies, Data Interpretation, Statistical, Female, Follow-Up Studies, Humans, Hyperaldosteronism, Hyperparathyroidism, Hypertension, Male, Middle Aged, Parathyroid Hormone, Renin-Angiotensin System
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