The DOI matches its Crossref record; 262 of the 262 references it cites were found in a registry or an index.
Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection
Open accessAbstract
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival, growth, and maintenance of neurons in key brain circuits involved in emotional and cognitive function. Convergent evidence indicates that neuroplastic mechanisms involving BDNF are deleteriously altered in major depressive disorder (MDD) and animal models of stress. Herein, clinical and preclinical evidence provided that stress-induced depressive pathology contributes to altered BDNF level and function in persons with MDD and, thereby, disruptions in neuroplasticity at the regional and circuit level. Conversely, effective therapeutics that mitigate depressive-related symptoms (e.g., antidepressants and physical activity) optimize BDNF in key brain regions, promote neuronal health and recovery of function in MDD-related circuits, and enhance pharmacotherapeutic response. A greater knowledge of the interrelationship between BDNF, depression, therapeutic mechanisms of action, and neuroplasticity is important as it necessarily precedes the derivation and deployment of more efficacious treatments.
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Cites
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Cited by
The impact of physical activity on psychological health during Covid-19 pandemic in Italy
Maugeri, G., Castrogiovanni, P., Battaglia, G., Pippi, R., D'Agata, V., Palma, A., Di Rosa, M., & Musumeci, G. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04315 · Cited by 870
Effects of Exercise on Brain and Cognition Across Age Groups and Health States
Stillman, C. M., Esteban-Cornejo, I., Brown, B., Bender, C. M., & Erickson, K. I. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.04.010 · Cited by 423
Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders
Jiang, Y., Zou, D., Li, Y., Gu, S., Dong, J., Ma, X., Xu, S., Wang, F., & Huang, J. H. (2022) · Pharmaceuticals · doi:10.3390/ph15101203 · Cited by 253
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Godlewska, B. R., & Harmer, C. J. (2021) · Psychopharmacology · doi:10.1007/s00213-019-05448-0 · Cited by 123
Metadata
- Authors
- Phillips, C.
- Venue
- Neural Plasticity
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-17
- ISSN
- 1687-5443 (ISSN-L)
- 2090-5904
- OpenAlex
- W2744579607
- Cited by
- 450
- References
- 262
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
