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Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications
Open accessAbstract
The objective of this review is to outline existing artificial mitochondria transfer techniques and to describe the future steps necessary to develop new therapeutic applications in medicine. Inspired by the symbiotic origin of mitochondria and by the cell’s capacity to transfer these organelles to damaged neighbors, many researchers have developed procedures to artificially transfer mitochondria from one cell to another. The techniques currently in use today range from simple coincubations of isolated mitochondria and recipient cells to the use of physical approaches to induce integration. These methods mimic natural mitochondria transfer. In order to use mitochondrial transfer in medicine, we must answer key questions about how to replicate aspects of natural transport processes to improve current artificial transfer methods. Another priority is to determine the optimum quantity and cell/tissue source of the mitochondria in order to induce cell reprogramming or tissue repair, in both in vitro and in vivo applications. Additionally, it is important that the field explores how artificial mitochondria transfer techniques can be used to treat different diseases and how to navigate the ethical issues in such procedures. Without a doubt, mitochondria are more than mere cell power plants, as we continue to discover their potential to be used in medicine.
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“Assessing the presence of extracellular mitochondria or their fragments by measuring ccf-mtDNA levels could allow on-flight direct estimation of cellular stress to take preventive measures of cumulative damage196,199–206.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [200]
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Metadata
- Authors
- Caicedo, A., Aponte, P. M., Cabrera, F., Hidalgo, C., & Khoury, M.
- Affiliations
- Universidad San Francisco de Quito (EC)
- Inserm (FR)
- Universidad de Los Andes, Chile (CL)
- Corresponding author
- Caicedo, Andrés
- Venue
- Stem Cells International
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-23
- ISSN
- 1687-966X (ISSN-L)
- 1687-9678
- PMC
- PMC5511681
- OpenAlex
- W2724908046
- Cited by
- 150
- References
- 180
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 22 · 2023: 27 · 2022: 21 · 2021: 22 · 2020: 20 · 2019: 9 · 2018: 4
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cells International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Funders
- Chilean FONDECYT (1170852)
- USFQ Publication Fund (1170852)
- USFQ Medical School (1170852)
- USFQ Chancellor (1170852)
- USFQ Collaboration (1170852)
- Universidad San Francisco (1170852)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial transfer, mitochondrial biogenesis, cellular reprogramming, tissue repair, mitochondrial transport, therapeutic applications, ethical considerations
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