Cited by 151Mitochondrial Function and PathologyMesenchymal stem cell researchAutophagy in Disease and Therapy

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Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications

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Caicedo, Andrés, Aponte, Pedro M., Cabrera, Francisco, Hidalgo, Carmen, Khoury, Maroun·2017·Stem Cells International

DOI 10.1155/2017/7610414PMC PMC5511681

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Abstract

The objective of this review is to outline existing artificial mitochondria transfer techniques and to describe the future steps necessary to develop new therapeutic applications in medicine. Inspired by the symbiotic origin of mitochondria and by the cell’s capacity to transfer these organelles to damaged neighbors, many researchers have developed procedures to artificially transfer mitochondria from one cell to another. The techniques currently in use today range from simple coincubations of isolated mitochondria and recipient cells to the use of physical approaches to induce integration. These methods mimic natural mitochondria transfer. In order to use mitochondrial transfer in medicine, we must answer key questions about how to replicate aspects of natural transport processes to improve current artificial transfer methods. Another priority is to determine the optimum quantity and cell/tissue source of the mitochondria in order to induce cell reprogramming or tissue repair, in both in vitro and in vivo applications. Additionally, it is important that the field explores how artificial mitochondria transfer techniques can be used to treat different diseases and how to navigate the ethical issues in such procedures. Without a doubt, mitochondria are more than mere cell power plants, as we continue to discover their potential to be used in medicine.

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Mesenchymal Stem Cells Transfer Mitochondria to the Cells with Virtually No Mitochondrial Function but Not with Pathogenic mtDNA Mutations
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Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy
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Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells
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Intercellular communication in malignant pleural mesothelioma: properties of tunneling nanotubes
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The Challenges of Mitochondrial Replacement
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Mitochondrial Transfer from Astrocytes to Neurons following Ischemic Insult: Guilt by Association?
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Biochip-based study of unidirectional mitochondrial transfer from stem cells to myocytes via tunneling nanotubes
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Increased activity of mitochondrial uncoupling protein 2 improves stress resistance in cultured endothelial cells exposed in vitro to high glucose levels
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CRISPR/Cas9 and mitochondrial gene replacement therapy: promising techniques and ethical considerations.
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Therapy for mitochondrial disorders: Little proof, high research activity, some promise
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Mitochondria transfer can enhance the murine embryo development
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Genetic basis of Alzheimer's dementia: role of mtDNA mutations
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Targeting autophagy and mitophagy for mitochondrial diseases treatment
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Preparation of Highly Coupled Rat Heart Mitochondria
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Interspecies mitochondrial fusion between mouse and human mitochondria is rapid and efficient
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Microinjection of serum-starved mitochondria derived from somatic cells affects parthenogenetic development of bovine and murine oocytes
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Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children
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Comparison of three methods for mitochondria isolation from the human liver cell line (HepG2).
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Molecular archaeology of the mitochondrial geonome
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From the first human gene-editing to the birth of three-parent baby
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Research works printed but not linked: 9

2016, Scientific Reports, 6, article 26057
2016, Biofabrication, 8
2014, Frontiers in Physiology, 5, 400
2016, Gastroenterology and Hepatology from Bed to Bench, 9, 105
2017, Biochimica et Biophysica Acta (BBA)-Bioenergetics
2017, Stem Cells International, 2017
2016, Nippon Ganka Gakkai Zasshi, 120, 210
2016, American Journal of Stem Cells, 5, 39
2015, Diabetologia, 59, 325

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Bustamante-Barrientos, F. A., Luque‐Campos, N., Araya, M. J., Lara-Barba, E., Solminihac, J. D., Pradenas, C., Molina, L., Herrera-Luna, Y., Utreras‐Mendoza, Y., Elizondo-Vega, R. J., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04493-w · Cited by 204

See all 151

Authors: Caicedo, A., Aponte, P. M., Cabrera, F., Hidalgo, C., & Khoury, M.
Affiliations: Universidad San Francisco de Quito (EC)
Inserm (FR)
Universidad de Los Andes, Chile (CL)
Corresponding author: Caicedo, Andrés
ORCID: Caicedo, Andrés
Aponte, Pedro M.
Cabrera, Francisco
Hidalgo, Carmen
Khoury, Maroun
Venue: Stem Cells International
Publisher: Wiley
Published: 2017
Volume: 2017
Pages: 1-23
ISSN: 1687-966X (ISSN-L)
1687-9678
DOI: 10.1155/2017/7610414
PMC: PMC5511681
OpenAlex: W2724908046
Cited by: 150
References: 180
Citations by year: 2026: 11 · 2025: 13 · 2024: 22 · 2023: 27 · 2022: 21 · 2021: 22 · 2020: 20 · 2019: 9 · 2018: 4
FWCI: 0.84
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Stem Cells International (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Greater South Information System
Funders: Chilean FONDECYT (1170852)
USFQ Publication Fund (1170852)
USFQ Medical School (1170852)
USFQ Chancellor (1170852)
USFQ Collaboration (1170852)
Universidad San Francisco (1170852)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondrial transfer, mitochondrial biogenesis, cellular reprogramming, tissue repair, mitochondrial transport, therapeutic applications, ethical considerations

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Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications

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