Resveratrol-enriched rice attenuates UVB-ROS-induced skin aging via downregulation of inflammatory cascades
Open accessAbstract
The skin is the outermost protective barrier between the internal and external environments in humans. Chronic exposure to ultraviolet (UV) radiation is a major cause of skin aging. UVB radiation penetrates the skin and induces ROS production that activates three major skin aging cascades: matrix metalloproteinase‐ (MMP‐) 1‐mediated aging; MAPK‐AP‐1/NF‐κB‐TNF‐α/IL‐6, iNOS, and COX‐2‐mediated inflammation‐induced aging; and p53‐Bax‐cleaved caspase‐3‐cytochrome C‐mediated apoptosis‐induced aging. These mechanisms are collectively responsible for the wrinkling and photoaging characteristic of UVB‐induced skin aging. There is an urgent requirement for a treatment that not only controls these pathways to prevent skin aging but also avoids the adverse effects often encountered when applying bioactive compounds in concentrated doses. In this study, we investigated the efficacy of genetically modified normal edible rice (NR) that produces the antiaging compound resveratrol (R) as a treatment for skin aging. This resveratrol‐enriched rice (RR) overcomes the drawbacks of R and enhances its antiaging potential by controlling the abovementioned three major pathways of skin aging. RR does not exhibit the toxicity of R alone and promisingly downregulates the pathways underlying UVB‐ROS‐induced skin aging. These findings advocate the use of RR as a nutraceutical for antiaging purposes.
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Under UV radiation, AP-1 and NF-κB are activated, leading to synthesis of nitric oxide synthase and cyclooxygenase, which cause secretion of pro-inflammatory cytokines IL-1β, IL-6, IL-8, and TNF-α in normal human dermal fibroblast cells.
“Under UV radiation, AP-1 and NF-κB are activated, leading to the synthesis of nitric oxide synthase and cyclooxygenase. These inflammatory enzymes cause the secretion of pro-inflammatory cytokines, including IL-1β, IL-6, IL-8, and tumor necrosis factor-α, in normal human dermal fibroblast cells [53].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [53]
Chronological aging and photoaging activate the same oxidative stress-related pathways.
“During the last decade, different studies demonstrated that chronological aging and photoaging activate the same oxidative stress-related pathways.”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [59]
Antioxidants inhibit damages induced by oxidation caused by ROS.
“In this context, antioxidants are known to inhibit damages induced by oxidation, caused by ROS, as described in this review in paragraph 5 [54, 59, 60].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [59]
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References 47 · Cited by 174
- Authors
- Subedi, L., Lee, T. H., Wahedi, H. M., Baek, S.-H., & Kim, S. Y.
- Affiliations
- Gachon University (KR)
- Yonsei University (KR)
- Quaid-i-Azam University (PK)
- Rural Development Administration (KR)
- Corresponding author
- Kim, Sun Yeou
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2017-01
- Volume
- 2017
- Issue
- 1
- Pages
- 8379539-8379539
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC5576414
- OpenAlex
- W2749067209
- Cited by
- 174
- References
- 47
- Citations by year
- 2026: 8 · 2025: 21 · 2024: 14 · 2023: 13 · 2022: 32 · 2021: 26 · 2020: 24 · 2019: 24 · 2018: 11 · 2017: 1
- FWCI
- 18.68
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-02-20)
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Rural Development Administration
- Ministry of Science, ICT and Future Planning (NRF-2017R1A4A1015594)
- Ministry of Agriculture, Food and Rural Affairs (114006041HD020)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- resveratrol, skin aging, photoaging, UV-B radiation, reactive oxygen species, MMP-1, NF-κB, TNF-α, interleukin-6, inducible nitric oxide synthase, cyclooxygenase-2, apoptosis, nutraceuticals, transgenic rice
- MeSH terms
- Resveratrol, Humans, Inflammation, Oryza, Stilbenes, Ultraviolet Rays, Down-Regulation, Skin Aging, Reactive Oxygen Species
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