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Cited by 83Bee Products Chemical AnalysisNatural Antidiabetic Agents StudiesHealthcare and Venom Research

Hypoglycaemic and Antioxidant Effects of Propolis of Chihuahua in a Model of Experimental Diabetes

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Rivera-Yañez, Nelly, Rodriguez-Canales, Mario, Nieto-Yañez, Oscar, Jimenez-Estrada, Manuel, Ibarra-Barajas, Maximiliano, Canales-Martinez, M. M., Rodriguez-Monroy, M. A.·2018·Evidence-Based Complementary and Alternative Medicine
DOI 10.1155/2018/4360356PMC PMC5866899
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Abstract

Propolis is a bee‐collected natural product that has been proven to have various bioactivities. This study tested the effects of a Mexican propolis on streptozotocin‐induced diabetes mellitus in a murine model. The results showed that an ethanolic extract of propolis of Chihuahua (EEPCh) significantly inhibited increases in blood glucose and the loss of body weight in diabetic mice. EEPCh increased plasma insulin levels in STZ‐diabetic mice, whereas, in untreated diabetic mice, there was no detection of insulin. EEPCh had a high antioxidant capacity (SA 50 = 15.75 μ g/mL), which was directly related to the concentrations of total phenols (314 mg GAE/g of extract) and flavonoids (6.25 mg QE/g of extract). In addition, increased activities of the enzymes superoxide dismutase, catalase, and glutathione peroxidase were observed in diabetic mice treated with EEPCh. Compounds such as pinocembrin, quercetin, naringin, naringenin, kaempferol, acacetin, luteolin, and chrysin were identified by HPLC‐MS analysis. This investigation demonstrated that propolis of Chihuahua possesses hypoglycaemic and antioxidant activities and can alleviate symptoms of diabetes mellitus in mice. These effects may be directly related to the chemical composition of propolis, as most of the compounds identified in propolis are reportedly active in terms of the different parameters evaluated in this work.

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Cited by

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Authors
Rivera-Yañez, N., Rodriguez-Canales, M., Nieto-Yañez, O., Jimenez-Estrada, M., Ibarra-Barajas, M., Canales-Martinez, M. M., & Rodriguez-Monroy, M. A.
Affiliations
  • Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Iztacala (MX)
  • Instituto Politécnico Nacional (MX)
ORCID
Venue
Evidence-Based Complementary and Alternative Medicine
Publisher
Wiley
Published
2018-01
Volume
2018
Issue
1
Pages
4360356-4360356
ISSN
  • 1741-427X (ISSN-L)
  • 1741-4288
DOI
10.1155/2018/4360356
PMC
PMC5866899
OpenAlex
W2789842233
Cited by
83
References
1
Citations by year
2026: 3 · 2025: 11 · 2024: 9 · 2023: 16 · 2022: 10 · 2021: 14 · 2020: 9 · 2019: 7 · 2018: 4
FWCI
7.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Consejo Nacional de Ciencia y Tecnología (265778)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Bee Products Chemical Analysis
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Pharmacology › Healthcare and Venom Research
Keywords
propolis, hypoglycemic activity, antioxidant activity, streptozotocin-induced diabetes, diabetes mellitus, insulin, superoxide dismutase, catalase, glutathione peroxidase, phenolic compounds, flavonoids, flavonoid glycosides, pinocembrin, quercetin, naringenin, kaempferol, acacetin, luteolin, chrysin, ethanolic propolis extract

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