Polyphenols and disease risk in epidemiologic studies
Open accessAbstract
Plant polyphenols, a large group of natural antioxidants, are serious candidates in explanations of the protective effects of vegetables and fruits against cancer and cardiovascular diseases. Epidemiologic studies are useful for evaluation of the human health effects of long-term exposure to physiologic concentrations of polyphenols, but reliable data on polyphenol contents of foods are still scarce. The aim of this review is to summarize available epidemiologic data on the health effects of polyphenols, focusing on the flavonoid subclasses of flavonols, flavones, and catechins and on lignans. Data obtained to date suggest beneficial effects of both flavonoids and lignans on cardiovascular diseases but not on cancer, with the possible exception of lung cancer. There is a need for more research on stroke and lung diseases such as asthma and chronic obstructive pulmonary disease. Most studies to date have included only flavonols and flavones. With data becoming available for other polyphenols, these compounds should be included in future studies. Careful design of prospective studies is important to offset some of the major drawbacks of epidemiologic studies, including residual confounding (by smoking and other dietary factors) and exposure assessment.
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Epidemiological studies show an inverse relationship between consumption of flavanol-containing foods and death from coronary artery disease.
“epidemiological investigations revealed an inverse correlation between the intake of flavanol-containing foods and coronary artery disease (CAD) mortality (1).”
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“The lower risk for all-cause mortality, CVD, cancer, and diabetes seen with high consumption of fruits and vegetables may be explained through multiple biological effects of magnesium, fiber, potassium, and flavonoids, including antioxidant activity, inhibition of inflammation, and angiogenesis.(62) Red meat consumpti…”
BackgroundOxidative stress and redox regulation of lung inflammation in COPD
Rahman, I., & Adcock, I. M. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00053805 · Cited by 943 · see citing works
Bioavailability of the polyphenols: Status and controversies
D’Archivio, M., Filesi, C., Varì, R., Scazzocchio, B., & Masella, R. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041321 · Cited by 950 · see citing works
Polyphenols and Human Health: The Role of Bioavailability
Lorenzo, C. D., Colombo, F., Biella, S., Stockley, C. S., & Restani, P. (2021) · Nutrients · doi:10.3390/nu13010273 · Cited by 914 · see citing works
“Sea buckthorn was administered because of its traditional use in Eastern countries and the encouraging results from clinical and epidemiological studies reporting a reduction in cardiovascular risk factors [44].”
BackgroundResources and Biological Activities of Natural Polyphenols
Li, A., Li, S., Zhang, Y., Xu, X., Chen, Y., & Li, H. (2014) · Nutrients · doi:10.3390/nu6126020 · Cited by 885 · see citing works
“Natural polyphenols have been widely studied, and found to possess many important bioactivities [2].”
BackgroundRothwell, J. A., Pérez‐Jiménez, J., Neveu, V., Medina‐Remón, A., M'hiri, N., Garcia-Lobato, P., Manach, C., Knox, C., Eisner, R., Wishart, D. S., et al. (2013) · Database · doi:10.1093/database/bat070 · Cited by 884 · see citing works
“The first release of Phenol-Explorer stored data in five tables (4).”
BackgroundBioavailability of bioactive food compounds: a challenging journey to bioefficacy.
Rein, M. J., Renouf, M., Cruz-Hernandez, C., Actis-Goretta, L., Thakkar, S. K., & Pinto, M. I. D. S. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04425.x · Cited by 763 · see citing works
Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects
Rahman, M. M., Rahaman, M. S., Islam, M. R., Rahman, F., Mithi, F. M., Alqahtani, T., Almikhlafi, M. A., Alghamdi, S. Q., Alruwaili, A. S., Hossain, M. S., et al. (2021) · Molecules · doi:10.3390/molecules27010233 · Cited by 900 · see citing works
“According to epidemiological research and related meta-analysis, long-term consumption of diets high in plant polyphenols protects against cancer, cardiovascular disease, diabetes, osteoporosis, and neurological diseases [4,5].”
BackgroundPolyphenols and Human Health: Prevention of Disease and Mechanisms of Action
Vauzour, D., Rodriguez‐Mateos, A., Corona, G., Oruña-Concha, M. J., & Spencer, J. P. E. (2010) · Nutrients · doi:10.3390/nu2111106 · Cited by 866 · see citing works
“artery disease [95] and anthocyanin and flavanone intake and reduced CVD related mortality [90].”
BackgroundFlavonoids as anti-inflammatory agents
Serafini, M., Peluso, I., & Raguzzini, A. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s002966511000162x · Cited by 826 · see citing works
Endothelial dysfunction — A major mediator of diabetic vascular disease
Sena, C. M., Pereira, A. M., & Seiça, R. M. F. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.08.006 · Cited by 796 · see citing works
“) and the incidence of cardiovascular disease [203-205].”
BackgroundNitric oxide and oxidative stress in vascular disease
Förstermann, U. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0808-2 · Cited by 780 · see citing works
LOTITO, S. B., & Frei, B. B. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.033 · Cited by 771 · see citing works
RetractedNatural polyphenols: An overview
Abbas, M., Saeed, F., Anjum, F. M., Afzaal, M., Tufail, T., Bashir, M. S., Ishtiaq, A., Hussain, S., & Suleria, H. A. R. (2017) · International Journal of Food Properties · doi:10.1080/10942912.2016.1220393 · Cited by 769 · see citing works
“An inverse correlation had been found in coronary disease and consumption of flavanols, flavonols, and flavones.([24]) Deaths rate related to cardiovascular disease were reduced with ingestion of flavanones and anthocyanins.”
BackgroundLandete, J. M. (2011) · Food Research International · doi:10.1016/j.foodres.2011.04.027 · Cited by 733 · see citing works
Multitargeted cancer prevention by quercetin
Murakami, A., Ashida, H., & Terao, J. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.046 · Cited by 729 · see citing works
Effect of Temperatures on Polyphenols during Extraction
Antony, A., & Farid, M. (2022) · Applied Sciences · doi:10.3390/app12042107 · Cited by 654 · see citing works
“The most well-studied subclass of polyphenols are flavonoids [4].”
BackgroundHass Avocado Composition and Potential Health Effects
Dreher, M. L., & Davenport, A. J. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.556759 · Cited by 640 · see citing works
“…phenolics on reducing CVD risk by reducing oxidative and inflammatory stress, enhancing blood flow and arterial endothelial health, and inhibiting platelet aggregation to help maintain vascular health (Chong et al., 2010; Arts and Hollman, 2005; Ghosh and Scheepens, 2009; Victor et al., 2009).”
BackgroundAntidiabetic Properties of Dietary Flavonoids: A Cellular Mechanism Review
Vinayagam, R., & Xu, B. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0057-7 · Cited by 597 · see citing works
Agro-industrial potential of exotic fruit byproducts as a source of food additives
Ayala-Zavala, J. F., Vega-Vega, V., Domínguez, C. R., Palafox-Carlos, H., Villa-Rodríguez, J. A., Siddiqui, M. W., Dávila-Aviña, J., & González-Aguilar, G. A. (2011) · Food Research International · doi:10.1016/j.foodres.2011.02.021 · Cited by 628 · see citing works
“On the other hand, it is important to mention the plant phenolic compounds as a large group of natural antioxidants ubiquitous in a diet high in fruits (Arts & Hollman, 2005).”
BackgroundFlavones and flavone synthases
Martens, S., & Mithöfer, A. (2005) · Phytochemistry · doi:10.1016/j.phytochem.2005.07.013 · Cited by 616 · see citing works
Pressurized hot water extraction of bioactives
Plaza, M., & Turner, C. (2015) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.02.022 · Cited by 582 · see citing works
“They were suggested as playing an important role in the prevention of several diseases associated to oxidative stress, such as cancer, cardiovascular and neurodegenerative diseases [86–88].”
BackgroundKell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
“tannins and anthocyanidins) [1821-1828] so implicated”
Genistein and Cancer: Current Status, Challenges, and Future Directions
Spagnuolo, C., Russo, G. L., Orhan, İ. E., Habtemariam, S., Daglia, M., Sureda, A., Nabavi, S. F., Devi, K. P., Loizzo, M. R., Tundis, R., et al. (2015) · Advances in Nutrition · doi:10.3945/an.114.008052 · Cited by 559 · see citing works
Eghbaliferiz, S., & Iranshahi, M. (2016) · Phytotherapy Research · doi:10.1002/ptr.5643 · Cited by 561 · see citing works
Anti-cancer potential of flavonoids: recent trends and future perspectives
Batra, P., & Sharma, A. K. (2013) · 3 Biotech · doi:10.1007/s13205-013-0117-5 · Cited by 563 · see citing works
“Epidemiological studies point to the fact that long-term consumption of diet rich in foods and vegetables reduces the risk of chronic diseases especially cancer (Wallstrom et al. 2000; Parr and Bolwell 2000; Arts and Hollman 2005; Patel 2008; Xiao et al. 2011).”
BackgroundMechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
Costa, L. G., Garrick, J. M., Roqué, P. J., & Pellacani, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2986796 · Cited by 550 · see citing works
Flavonoids as natural phenolic compounds and their role in therapeutics: an overview
Mutha, R. E., Tatiya, A. U., & Surana, S. J. (2021) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-020-00161-8 · Cited by 626 · see citing works
“Afterward, various epidemiological research activities and accompanying meta-analyses intensely recommended protection offered against the development of diabetes, cancer, osteoporosis, cardiovascular diseases and neurodegenerative diseases by long-term intake of plant polyphenols in our daily diet [9, 10].”
BackgroundChiavaroli, L., Viguiliouk, E., Nishi, S., Blanco Mejia, S., Rahelić, D., Kahleová, H., Salas-Salvadó, J., Kendall, C., & Sievenpiper, J. (2019) · Nutrients · doi:10.3390/nu11020338 · Cited by 548 · see citing works
“CVD benefit may be the result of the biological effects of other key nutrients richly found in foods emphasized in the DASH dietary pattern, such as magnesium, potassium, and phytochemicals, including flavonoids, which have been demonstrated to have anti-inflammatory and anti-antioxidant activity and result in reducti…”
BackgroundMetabolic fate of polyphenols in the human superorganism
van Duynhoven, J., Vaughan, E. E., Jacobs, D. M., A. Kemperman, R., van Velzen, E. J. J., Gross, G., Roger, L. C., Possemiers, S., Smilde, A. K., Doré, J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000098107 · Cited by 540 · see citing works
“Prospective and crosssectional epidemiological studies have associated polyphenol consumption with reduced risk for cardiovascular disease (2) and cancer (3).”
BackgroundRecent advances in understanding the anti-diabetic actions of dietary flavonoids
Babu, P. V. A., Liu, D., & Gilbert, E. R. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.06.003 · Cited by 549 · see citing works
“Epidemiological studies and meta-analyses suggested an inverse relationship between the consumption of flavonoid-rich diets and development of many aging-associated diseases including cancers, cardiovascular disease, diabetes, osteoporosis, and neurodegenerative disorders [9, 10].”
BackgroundFlavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults
McCullough, M. L., Peterson, J. J., Patel, R., Jacques, P. F., Shah, R. A., & Dwyer, J. T. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.016634 · Cited by 535 · see citing works
Tissue Distribution of Quercetin in Rats and Pigs
de Boer, V. C. J., Dihal, A. A., van der Woude, H., Arts, I. C. W., Wolffram, S., Alink, G. M., Rietjens, I. M. C. M., Keijer, J., & Hollman, P. C. H. (2005) · Journal of Nutrition · doi:10.1093/jn/135.7.1718 · Cited by 519 · see citing works
“Quercetin is a plant-derived, dietary compound with potentially beneficial effects on cardiovascular diseases (1,2).”
BackgroundAn overview on the role of dietary phenolics for the treatment of cancers
Anantharaju, P. G., Prathima, C., Vimalambike, M. G., & Madhunapantula, S. V. (2016) · Nutrition Journal · doi:10.1186/s12937-016-0217-2 · Cited by 525 · see citing works
“These phenolic compounds are known to exhibit potent anti-cancer activities as well as combat various diseases associated with oxidative stress [4].”
BackgroundMilder, I. E. J., Arts, I. C. W., van de Putte, B., Venema, D. P., & Hollman, P. C. H. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051371 · Cited by 503 · see citing works
“Lignans possess several biological activities, such as antioxidant and (anti)oestrogenic properties, and may thus reduce the risk of certain cancers as well as cardiovascular diseases (Adlercreutz et al. 1992; Adlercreutz & Mazur, 1997; Raffaelli et al. 2002; Arts & Hollman, 2005).”
BackgroundCassidy, A., Mukamal, K. J., Liu, L., FRANZ, M. M., Eliassen, A. H., & Rimm, E. B. (2013) · Circulation · doi:10.1161/circulationaha.112.122408 · Cited by 497 · see citing works
Holt, E. M., Steffen, L. M., Moran, A., Basu, S., Steinberger, J., Ross, J. A., Hong, C.-P., & Sinaiko, A. R. (2009) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.11.036 · Cited by 496 · see citing works
Recent advances in the extraction of bioactive compounds with subcritical water: A review
Zhang, J., Wen, C., Zhang, H., Duan, Y., & Ma, H. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.11.018 · Cited by 490 · see citing works
Flavonoid Intake and Cognitive Decline over a 10-Year Period
Letenneur, L., Proust‐Lima, C., Gouge, A. L., Dartigues, J. F., & Barberger‐Gateau, P. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm036 · Cited by 484 · see citing works
“Polyphenols and flavonoids have been linked to a lower risk of developing several pathologies, from cardiovascular diseases (reduction of mortality risk up to 65 percent) and cancers (inverse association between lignans and breast cancer risk) to asthma (inverse association between asthma and intake of flavonols, flav…”
BackgroundPhenolic Acids in Berries, Fruits, and Beverages
Mattila, P. H., Hellström, J., & Törrönen, R. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0615247 · Cited by 479 · see citing works
Oxidative stress in asthma and COPD: Antioxidants as a therapeutic strategy
Kirkham, P., & Rahman, I. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.015 · Cited by 462 · see citing works
“Several epidemiological studies have been undertaken, which have established a beneficial link between polyphenol intake and lower disease risk with many of the clinical benefits being attributed to both the antioxidant and anti-inflammatory properties of polyphenols (Arts & Hollman, 2005).”
BackgroundFlavanol monomer-induced changes to the human faecal microflora
Tzounis, X., Vulevic, J., Kuhnle, G., George, T. W., Leonczak, J., Gibson, G. R., Kwik-Uribe, C. L., & Spencer, J. P. E. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507853384 · Cited by 454 · see citing works
Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review
Amiot, M. J., Riva, C., & Vinet, A. (2016) · Obesity Reviews · doi:10.1111/obr.12409 · Cited by 448 · see citing works
Characterization of Phenolic Composition in Lamiaceae Spices by LC-ESI-MS/MS
Hossain, M. B., Rai, D. K., Brunton, N. P., Martín‐Diana, A. B., & Barry‐Ryan, C. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102042g · Cited by 447 · see citing works
Nutrition, physical activity, and cardiovascular disease: An update
IGNARRO, L., Balestrieri, M. L., & Claudio Napoli, A. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.06.030 · Cited by 443 · see citing works
“Epidemiologic studies tend to confirm the protective effects of poly-phenol consumption against CVD [84].”
Dietary Intake and Major Food Sources of Polyphenols in Finnish Adults3
Ovaskainen, M., Törrönen, R., Koponen, J. M., Sinkko, H., Hellström, J., Reinivuo, H., & Mattila, P. H. (2008) · Journal of Nutrition · doi:10.1093/jn/138.3.562 · Cited by 434 · see citing works
Polyphenols: Benefits to the Cardiovascular System in Health and in Aging
Khurana, S., Venkataraman, K., Hollingsworth, A., Piché, M., & Tai, T. C. (2013) · Nutrients · doi:10.3390/nu5103779 · Cited by 438 · see citing works
“studies with animals have been performed to firstly establish a cause and effect link between a diet rich in polyphenols and improvement in health, and secondly to gain insight into the mechanisms of the mode of action and protection bestowed by these compounds [4,35–37].”
BackgroundOxidative Stress and Antioxidants in Disease and Cancer: A Review
Gupta, R. K., Patel, A., Shah, N., Chaudhary, A. K., Jha, U. K., Yadav, U. C., Gupta, P. K., & Pakuwal, U. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.11.4405 · Cited by 432 · see citing works
“Asian Pacific Journal of Cancer Prevention, Vol 15, 2014 4408 states; wherein, oxidative stress has been established as a causative mechanism (Arts and Hollman, 2005).”
BackgroundDietary intake of 337 polyphenols in French adults
Pérez‐Jiménez, J., Fezeu, L., Touvier, M., Arnault, N., Manach, C., Herçberg, S., Galan, P., & Scalbert, A. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.007096 · Cited by 425 · see citing works
“Cyanidin 3-O-rutinoside Anthocyanins 11 6 21 Cherries (82), plums (15), black currants (1), black olives (1)”
BackgroundInfluentialRomán, G. C., Jackson, R. E., Gadhia, R. R., Roman, A., & Reis, J. J. (2019) · Revue Neurologique · doi:10.1016/j.neurol.2019.08.005 · Cited by 422 · see citing works
Polyphenols, oral health and disease: A review
Petti, S., & Scully, C. M. (2009) · Journal of Dentistry · doi:10.1016/j.jdent.2009.02.003 · Cited by 411 · see citing works
Hollman, P. C. H., Cassidy, A., Comte, B., Heinonen, M., Richelle, M., Richling, E., Serafini, M., Scalbert, A., Sies, H., & Vidry, S. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.131490 · Cited by 406 · see citing works
Self-citationBallester, A., Molthoff, J. W., de Vos, R. C. H., Hekkert, B. T. L., Orzáez, D., Fernández-Moreno, J.-P., Tripodi, P., Grandillo, S., Martin, C. R., Heldens, J., et al. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.147322 · Cited by 403 · see citing works
“Furthermore, they are good hydrophilic antioxidants and are increasingly recognized as health-protecting components in the human diet (Arts and Hollman, 2005; Hooper and Cassidy, 2006; Lotito and Frei, 2006; Fraga, 2007; Tapas et al., 2008).”
BackgroundA survey of modulation of gut microbiota by dietary polyphenols
Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., Moreno-Arribas, M. V., & Bartolomé, B. (2015) · BioMed Research International · doi:10.1155/2015/850902 · Cited by 396 · see citing works
Astrocyte Heterogeneity: Impact to Brain Aging and Disease
Matias, I., Morgado, J., & Gomes, F. C. A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00059 · Cited by 387 · see citing works
The Role of Oxidative Stress in the Pathophysiology of Gestational Diabetes Mellitus
Lappas, M., Hiden, U., Desoye, G., Froehlich, J., Mouzon, S. H.-D., & Jawerbaum, A. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3765 · Cited by 442 · see citing works
“There is some evidence to suggest that dietary phyto-chemicals, including flavonoids, may be of potential benefit in the management of GDM. Epidemiological studies have suggested beneficial health effects of the chronic consumption of flavonoid-rich foods (8, 247).”
Aaby, K., Ekeberg, D., & Skrede, G. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0702592 · Cited by 378 · see citing works
Angeli, V., Miguel Silva, P., Crispim Massuela, D., Khan, M. W., Hamar, A., Khajehei, F., Graeff-Hönninger, S., & Piatti, C. (2020) · Foods · doi:10.3390/foods9020216 · Cited by 375 · see citing works
“It has been suggested that such compounds can aid the risk reduction of cardiovascular diseases, neurodegenerative disorders, and diabetes [29,30].”
BackgroundChakraborty, S. B., & Hancz, C. (2011) · Reviews in Aquaculture · doi:10.1111/j.1753-5131.2011.01048.x · Cited by 370 · see citing works
Bo’, C. D., Bernardi, S., Marino, M., Porrini, M., Tucci, M., Guglielmetti, S., Cherubini, A., Carrieri, B., Kirkup, B. M., Kroon, P. A., et al. (2019) · Nutrients · doi:10.3390/nu11061355 · Cited by 367 · see citing works
“type II diabetes, and neurodegenerative diseases [2].”
BackgroundErdman, J. W., Balentine, D. A., Arab, L., Beecher, G. R., Dwyer, J. T., Folts, J. D., Harnly, J. M., Hollman, P. C. H., Keen, C. L., Mazza, G., et al. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.718s · Cited by 361 · see citing works
“This is impossible when correlations between flavonoids and other components are high (114).”
BackgroundKell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works
“Many are polyphenols (ChEBI 26195) (Amic et al. 2007; Arts and Hollman 2005; Auclair et al. 2009; Cemeli et al. 2009; Cheynier 2005; Geronikaki and Gavalas 2006; Halliwell 2007; Jovanovic and Simic 2000; Kandaswami and Middleton 1994; Kiokias et al. 2008; Korkina and Afanas’ev 1997; Linseisen and…”
BackgroundApplication of phytochemicals as growth‐promoters and endocrine modulators in fish culture
Chakraborty, S. B., Horn, P. A., & Hancz, C. (2013) · Reviews in Aquaculture · doi:10.1111/raq.12021 · Cited by 359 · see citing works
Health-promoting effects of the citrus flavanone hesperidin
Li, C., & Schluesener, H. J. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.906382 · Cited by 357 · see citing works
“Epidemiological studies reported an inverse relationship between their intake and the risk of neurological disorders, cardiovascular events, and some chronic diseases (Knekt et al., 2002; Arts and Hollman, 2005; Devore et al., 2012; Gao et al., 2012).”
BackgroundQuantitative analysis of antiradical phenolic constituents from fourteen edible Myrtaceae fruits
Reynertson, K. A., Yang, H., Jiang, B., Basile, M. J., & Kennelly, E. J. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.01.021 · Cited by 355 · see citing works
Extraction and Analysis of Polyphenols: Recent trends
Ajila, C. M., Brar, S. K., Verma, M., Tyagi, R. D., Godbout, S., & Valero, J. R. L. (2010) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2010.513677 · Cited by 354 · see citing works
“Hence, plant lignans are considered to be one of the several classes of phytoestrogen and are also effective as antioxidants and aid in reducing the risk of cancer and cardiovascular diseases (Vanharanta et al., 1999; Arts and Hollman, 2005).”
BackgroundIn Vitro Models for Studying Secondary Plant Metabolite Digestion and Bioaccessibility
Alminger, M., Aura, A., Bohn, T., Dufour, C., El, S. N., Gomes, A., Karakaya, S., Martínez‐Cuesta, M. C., McDougall, G. J., Requena, T., et al. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12081 · Cited by 354 · see citing works
Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
Imran, M., Rauf, A., Shah, Z. A., Saeed, F., Imran, A., Arshad, M. U., Ahmad, B., Bawazeer, S., Atif, M., Peters, D. G., et al. (2018) · Phytotherapy Research · doi:10.1002/ptr.6227 · Cited by 341 · see citing works
Risks and safety of polyphenol consumption
Mennen, L. I., Walker, R., Bennetau-Pelissero, C., & Scalbert, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.326s · Cited by 340 · see citing works
“It should be noted that these particular effects are unlikely to occur with regular Western diets, which are characterized by a much lower tannin intake (52).”
BackgroundPlant Metabolites and Nutritional Quality of Vegetables
Hounsome, N., Hounsome, B., Tomos, A. D., & Edwards‐Jones, G. (2008) · Journal of Food Science · doi:10.1111/j.1750-3841.2008.00716.x · Cited by 332 · see citing works
Phenol‐Based Antioxidants and the In Vitro Methods Used for Their Assessment
Craft, B. D., Kerrihard, A. L., Amarowicz, R., & Pegg, R. B. (2012) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2011.00173.x · Cited by 329 · see citing works
The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?
Megur, A., Baltriukienė, D., Bukelskienė, V., & Burokas, A. (2020) · Nutrients · doi:10.3390/nu13010037 · Cited by 323 · see citing works
Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration
Sutherland, B. A., Rahman, R. M. A., & Appleton, I. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.10.005 · Cited by 325 · see citing works
“This is significant because many fruits and vegetables also have catechin and flavonol components (see Table 1) [62].”
BackgroundProperties of Bread Dough with Added Fiber Polysaccharides and Phenolic Antioxidants: A Review
Sivam, A. S., Sun‐Waterhouse, D., Quek, S. Y., & Perera, C. O. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01815.x · Cited by 323 · see citing works
“…ise Re vie ws in Fo od Sc ien ceFiber, phenolics, and bread . . . peroxide (H2O2), and lipid peroxide radicals have been associated with chronic degenerative diseases such as cancer, inflammatory, aging, cardiovascular, and neurodegenerative disease (Shahidi and Naczk 1995; Arts and Hollman 2005).”
BackgroundImmune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota
Peterson, C. T., Sharma, V., Elmén, L., & Peterson, S. N. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12474 · Cited by 318 · see citing works
Wang, T., He, F., & Chen, G. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.01.033 · Cited by 316 · see citing works
Phenolic compounds and antioxidant activities of edible flowers from Thailand
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“Epidemiological studies indicate that fruit and vegetables have protective effects against degenerative diseases such as cancer and cardiovascular disease (2,3).”
BackgroundOxidative stress and free radicals in COPD – implications and relevance for treatment
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- Authors
- Arts, I. C., & Hollman, P. C.
- Affiliations
- Wageningen University & Research (NL)
- Corresponding author
- Arts, Ilja CW
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 81
- Issue
- 1
- Pages
- 317S-325S
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2129133439
- Cited by
- 1,916
- References
- 74
- Citations by year
- 2026: 20 · 2025: 37 · 2024: 72 · 2023: 55 · 2022: 66 · 2021: 82 · 2020: 77 · 2019: 106 · 2018: 107 · 2017: 103 · 2016: 130 · 2015: 119 · 2014: 138 · 2013: 132 · 2012: 114
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- ZonMw
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- plant polyphenols, flavonoids, flavonols, flavones, catechins, lignans, cardiovascular disease, cancer risk, lung cancer, stroke, asthma, chronic obstructive pulmonary disease, dietary exposure assessment, residual confounding, prospective study design
- MeSH terms
- Adult, Animals, Antioxidants, Cardiovascular Diseases, Clinical Trials as Topic, Epidemiologic Methods, Female, Flavonoids, Humans, Male, Neoplasms, Phenols, Prospective Studies, Risk Factors, Polyphenols
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