The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Limitations of Serum Ferritin in Diagnosing Iron Deficiency in Inflammatory Conditions
Open accessAbstract
Patients with inflammatory conditions such as inflammatory bowel disease (IBD), chronic heart failure (CHF), and chronic kidney disease (CKD) have high rates of iron deficiency with adverse clinical consequences. Under normal circumstances, serum ferritin levels are a sensitive marker for iron status but ferritin is an acute-phase reactant that becomes elevated in response to inflammation, complicating the diagnosis. Proinflammatory cytokines also trigger an increase in hepcidin, which restricts uptake of dietary iron and promotes sequestration of iron by ferritin within storage sites. Patients with inflammatory conditions may thus have restricted availability of iron for erythropoiesis and other cell functions due to increased hepcidin expression, despite normal or high levels of serum ferritin. The standard threshold for iron deficiency (<30 μ g/L) therefore does not apply and transferrin saturation (TSAT), a marker of iron availability, should also be assessed. A serum ferritin threshold of <100 μ g/L or TSAT < 20% can be considered diagnostic for iron deficiency in CHF, CKD, and IBD. If serum ferritin is 100–300 μ g/L, TSAT < 20% is required to confirm iron deficiency. Routine surveillance of serum ferritin and TSAT in these at-risk groups is advisable so that iron deficiency can be detected and managed.
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Cited by
Wang, Y., Yu, L., Ding, J., & Chen, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010095 · Cited by 294
Iron deficiency anemia among women: An issue of health equity
Tang, G. H., & Sholzberg, M. (2024) · Blood Reviews · doi:10.1016/j.blre.2023.101159 · Cited by 60
Chronic Adherence to a Ketogenic Diet Modifies Iron Metabolism in Elite Athletes
MCKAY, A. K. A., PEELING, P., PYNE, D. B., WELVAERT, M., TEE, N., LECKEY, J. J., SHARMA, A. P., ROSS, M. L. R., GARVICAN-LEWIS, L. A., SWINKELS, D. W., et al. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001816 · Cited by 53
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Prevalence of iron deficiency using 3 definitions among women in the US and Canada
Barton, J. C., Wiener, H. W., Barton, J. C., & Acton, R. T. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.13967 · Cited by 15
Metadata
- Authors
- Dignass, A., Farrag, K., & Stein, J.
- Venue
- International Journal of Chronic Diseases
- Publisher
- Wiley
- Published
- 2018
- Volume
- 2018
- Pages
- 1-11
- ISSN
- 2314-5749 (ISSN-L)
- 2356-6981
- OpenAlex
- W2790659043
- Cited by
- 286
- References
- 110
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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