The DOI matches its Crossref record; 186 of the 186 references it cites were found in a registry or an index.
Iron Metabolism in Cancer
Open accessAbstract
Demanded as an essential trace element that supports cell growth and basic functions, iron can be harmful and cancerogenic though. By exchanging between its different oxidized forms, iron overload induces free radical formation, lipid peroxidation, DNA, and protein damages, leading to carcinogenesis or ferroptosis. Iron also plays profound roles in modulating tumor microenvironment and metastasis, maintaining genomic stability and controlling epigenetics. in order to meet the high requirement of iron, neoplastic cells have remodeled iron metabolism pathways, including acquisition, storage, and efflux, which makes manipulating iron homeostasis a considerable approach for cancer therapy. Several iron chelators and iron oxide nanoparticles (IONPs) has recently been developed for cancer intervention and presented considerable effects. This review summarizes some latest findings about iron metabolism function and regulation mechanism in cancer and the application of iron chelators and IONPs in cancer diagnosis and therapy.
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1 retracted
Yang, Z. L., Duan, J., Wang, J., Liu, Q., Shang, R., Yang, X., Lu, P., Xia, C., Wang, L. Q., & Dou, K. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s155537 · Cited by 81
RetractedFerroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Two to tango: Regulation of Mammalian iron metabolism
Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120
Iron and cancer: more ore to be mined
Torti, S. V., & Torti, F. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3495 · Cited by 1,621
Role of GPX4 in ferroptosis and its pharmacological implication
Seibt, T. M., Proneth, B., & Conrad, M. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.014 · Cited by 1,520
A Red carpet for iron metabolism
Muckenthaler, M. U., Rivella, S., Hentze, M. W., & Galy, B. (2017) · Cell · doi:10.1016/j.cell.2016.12.034 · Cited by 1,319
Iron homeostasis in host defence and inflammation
Ganz, T., & Nemeth, E. (2015) · Nature Reviews Immunology · doi:10.1038/nri3863 · Cited by 843
NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
Alvarez, S. W., Sviderskiy, V. O., Terzi, E. M., Papagiannakopoulos, T., Moreira, A. L., Adams, S., Sabatini, D. M., Birsoy, K., & Possemato, R. (2017) · Nature · doi:10.1038/nature24637 · Cited by 787
Emerging Strategies of Cancer Therapy Based on Ferroptosis
Shen, Z., Song, J., Yung, B. C., Zhou, Z., Wu, A., & Chen, X. (2018) · Advanced Materials · doi:10.1002/adma.201704007 · Cited by 740
The tumor suppressor protein p53 and the ferroptosis network
Kang, R., Kroemer, G., & Tang, D. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.074 · Cited by 698
Research works printed but not linked: 13
- Sahni, 2014, NDRG1 as a molecular target to inhibit the epithelial-mesenchymal transition: The case for developing inhibitors of metastasis, Future Med. Chem., 6, 1241, 10.4155/fmc.14.80 · doi:10.4155/fmc.14.80
- Wang, 2018, The MYB/miR-130a/NDRG2 axis modulates tumor proliferation and metastatic potential in salivary adenoid cystic carcinoma, Cell Death Dis., 9, 917, 10.1038/s41419-018-0966-2 · doi:10.1038/s41419-018-0966-2
- Yang, 2018, NDRG2 suppresses proliferation, migration, invasion and epithelial-mesenchymal transition of esophageal cancer cells through regulating the AKT/XIAP signaling pathway, Int. J. Biochem. Cell Boil., 99, 43, 10.1016/j.biocel.2018.03.003 · DOI
- Chen, 2018, Potential role of NDRG2 in reprogramming cancer metabolism and epithelial-to-mesenchymal transition, Histol. Histopathol., 33, 655
- Zhang, A., Wang, B., Yang, M., Shi, H., and Gan, W. (2015). beta2-microglobulin induces epithelial-mesenchymal transition in human renal proximal tubule epithelial cells in vitro. BMC Nephrol., 16. · doi:10.1186/s12882-015-0057-x
- Koh, 2015, HGF mediated upregulation of lipocalin 2 regulates MMP9 through nuclear factor-kappaB activation, Oncol. Rep., 34, 2179, 10.3892/or.2015.4189 · doi:10.3892/or.2015.4189
- Arosio, 2014, New signaling pathways for hepcidin regulation, Blood, 123, 1433, 10.1182/blood-2014-01-548594 · doi:10.1182/blood-2014-01-548594
- Barteselli, 2015, Functional and Structural Abnormalities in Deferoxamine Retinopathy: A Review of the Literature, BioMed Res. Int., 2015, 249617
- Piro, 2018, Sustained Erythroid Response in a Patient with Myelofibrosis Receiving Concomitant Treatment with Ruxolitinib and Deferasirox, Chemotherapy, 63, 107, 10.1159/000486822 · doi:10.1159/000486822
- Fu, 2017, IONP-doped nanoparticles for highly effective NIR-controlled drug release and combination tumor therapy, Int. J. Nanomed., 12, 3751, 10.2147/IJN.S113963 · doi:10.2147/ijn.s113963
- Tsai, 2018, Tuning the Distance of Rattle-Shaped IONP@Shell-in-Shell Nanoparticles for Magnetically-Targeted Photothermal Therapy in the Second Near-Infrared Window, ACS Appl. Mater. Interfaces, 10, 1508, 10.1021/acsami.7b14593 · doi:10.1021/acsami.7b14593
- Liu, 2010, The immunotherapeutic effect of Fe3O4 nanoparticles as adjuvants on mice H22 live cancer, J. Nanosci. Nanotechnol., 10, 514, 10.1166/jnn.2010.1591 · doi:10.1166/jnn.2010.1591
- Jin, 2010, Influence of magnetic Fe3O4 nanoparticle on functions of lymphocytes and macrophages in mice, Zhongguo Shi Yan Xue Ye Xue Za Zhi, 18, 136
Cited by
Iron Metabolism and Immune Regulation
Ni, S., Yuan, Y., Kuang, Y., & Li, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.816282 · Cited by 259
Rusu, I. G., Suharoschi, R., Vodnar, D. C., Pop, C. R., Socaci, S. A., Vulturar, R., Istrati, M., Moroșan, I., Fărcaș, A. C., Kerezsi, A. D., et al. (2020) · Nutrients · doi:10.3390/nu12071993 · Cited by 185
The Multifaceted Role of Heme in Cancer
Fiorito, V., Chiabrando, D., Petrillo, S., Bertino, F., & Tolosano, E. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01540 · Cited by 129
Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma
Yao, F., Cui, X., Zhang, Y., Bei, Z., Wang, H., Zhao, D., Wang, H., & Yang, Y. (2021) · Oncology Letters · doi:10.3892/ol.2021.12918 · Cited by 75
Metadata
- Authors
- Wang, Y., Yu, L., Ding, J., & Chen, Y.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-12-27
- Volume
- 20
- Issue
- 1
- Pages
- 95
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2907110005
- Cited by
- 294
- References
- 186
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Open access
- gold
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