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Cited by 298

The DOI matches its Crossref record; 174 of the 174 references it cites were found in a registry or an index.

Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

Open access
Mahmoud, Ayman M., Hernández Bautista, Rene J., Sandhu, Mansur A., Hussein, Omnia E.·2019·Oxidative Medicine and Cellular Longevity

Abstract

The prevalence of cardiovascular disease (CVD) is increasing over time. CVD is a comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess several biological activities and have emerged as efficient therapeutics for the treatment of CVD. Citrus flavonoids scavenge free radicals, improve glucose tolerance and insulin sensitivity, modulate lipid metabolism and adipocyte differentiation, suppress inflammation and apoptosis, and improve endothelial dysfunction. The intake of citrus flavonoids has been associated with improved cardiovascular outcomes. Although citrus flavonoids exerted multiple beneficial effects, their mechanisms of action are not completely established. In this review, we summarized recent findings and advances in understanding the mechanisms underlying the protective effects of citrus flavonoids against oxidative stress, inflammation, diabetes, dyslipidemia, endothelial dysfunction, and atherosclerosis. Further studies and clinical trials to assess the efficacy and to explore the underlying mechanism(s) of action of citrus flavonoids are recommended.

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Metadata

Authors
Mahmoud, A. M., Hernández Bautista, R. J., Sandhu, M. A., & Hussein, O. E.
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2019-03-10
Volume
2019
Pages
1-19
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
OpenAlex
W2921371127
Cited by
298
References
174
FWCI
22.17
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health. https://app.cochat.ai/papers/10.1155/2019/5484138
The paper
Mahmoud, A. M., Hernández Bautista, R. J., Sandhu, M. A., & Hussein, O. E. (2019). Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2019/5484138

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