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Flavonoids regulate LDLR through different mechanisms tied to their specific structures

Bjune, Katrine, Halvorsen, Pia Skovholt, Wangensteen, Helle, Leren, Trond P., Bogsrud, Martin Prøven, Strøm, Thea Bismo·2024·Journal of Lipid Research
DOI 10.1016/j.jlr.2024.100539PMC PMC11058080
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  • Several compounds known to increase LDLR mRNA stability directly have also been reported to decrease expression of SREBP-regulated genes, including PCSK9, exhibiting a dual effect.

    “Interestingly, while these compounds are known to increase LDLR mRNA stability directly, several have also been reported to decrease the expression of SREBP-regulated genes, including PCSK9, thus exhibiting a dual effect that could have significant implications for cholesterol management [19,35,42].”

    From The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms (2025) · cites this paper as [35]

    The Results section on LDLR mRNA stabilization reports that kaempferol and quercetin increased LDLR mRNA half-life. The cited paper does not report that these mRNA-stabilizing compounds also decreased expression of SREBP-regulated genes, including PCSK9; its Results on the LDLR promoter instead describe quercetin as acting through an SRE-independent mechanism. No page numbers were available in our copy. (LLM, conf=0.87)

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Research works printed but not linked: 45

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Metadata

Authors
Bjune, K., Halvorsen, P. S., Wangensteen, H., Leren, T. P., Bogsrud, M. P., & Strøm, T. B.
ORCID
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2024-05
Volume
65
Issue
5
Pages
100539
ISSN
0022-2275
DOI
10.1016/j.jlr.2024.100539
PMC
PMC11058080
Cited by
13
References
1
Language
en
Licence

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