The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.
Role of Nrf2 and Its Activators in Respiratory Diseases
Open accessAbstract
Transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a major regulator of antioxidant response element- (ARE-) driven cytoprotective protein expression. The activation of Nrf2 signaling plays an essential role in preventing cells and tissues from injury induced by oxidative stress. Under the unstressed conditions, natural inhibitor of Nrf2, Kelch-like ECH-associated protein 1 (Keap1), traps Nrf2 in the cytoplasm and promotes the degradation of Nrf2 by the 26S proteasome. Nevertheless, stresses including highly oxidative microenvironments, impair the ability of Keap1 to target Nrf2 for ubiquitination and degradation, and induce newly synthesized Nrf2 to translocate to the nucleus to bind with ARE. Due to constant exposure to external environments, including diverse pollutants and other oxidants, the redox balance maintained by Nrf2 is fairly important to the airways. To date, researchers have discovered that Nrf2 deletion results in high susceptibility and severity of insults in various models of respiratory diseases, including bronchopulmonary dysplasia (BPD), respiratory infections, acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), asthma, idiopathic pulmonary fibrosis (IPF), and lung cancer. Conversely, Nrf2 activation confers protective effects on these lung disorders. In the present review, we summarize Nrf2 involvement in the pathogenesis of the above respiratory diseases that have been identified by experimental models and human studies and describe the protective effects of Nrf2 inducers on these diseases.
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1 retracted
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Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
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Cited by
Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms
He, Y.-Q., Zhou, C.-C., Yu, L.-Y., Wang, L., Deng, J.-L., Tao, Y.-L., Zhang, F., & Chen, W.-S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105224 · Cited by 412
Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke
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Oxidative Stress in Chronic Obstructive Pulmonary Disease
Barnes, P. J. (2022) · Antioxidants · doi:10.3390/antiox11050965 · Cited by 281
Feng, L., Zhao, K., Sun, L., Yin, X., Zhang, J., Liu, C., & Li, B. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03042-7 · Cited by 277
Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections
Stubbs, B. J., Koutnik, A. P., Goldberg, E. L., Upadhyay, V., Turnbaugh, P. J., Verdin, E., & Newman, J. C. (2020) · Med · doi:10.1016/j.medj.2020.06.008 · Cited by 71
Metadata
- Authors
- Liu, Q., Gao, Y., & Ci, X.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2019-01-08
- Volume
- 2019
- Pages
- 1-17
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W2910546024
- Cited by
- 267
- References
- 173
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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