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Cited by 708

The DOI matches its Crossref record; 281 of the 281 references it cites were found in a registry or an index.

Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease

Open access
Steven, Sebastian, Frenis, Katie, Oelze, Matthias, Kalinovic, Sanela, Kuntic, Marin, Bayo Jimenez, Maria Teresa, Vujacic-Mirski, Ksenija, Helmstädter, Johanna, Kröller-Schön, Swenja, Münzel, Thomas, Daiber, Andreas·2019·Oxidative Medicine and Cellular Longevity
DOI 10.1155/2019/7092151
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Abstract

Cardiovascular disease is a leading cause of death and reduced quality of life, proven by the latest data of the Global Burden of Disease Study, and is only gaining in prevalence worldwide. Clinical trials have identified chronic inflammatory disorders as cardiovascular risks, and recent research has revealed a contribution by various inflammatory cells to vascular oxidative stress. Atherosclerosis and cardiovascular disease are closely associated with inflammation, probably due to the close interaction of inflammation with oxidative stress. Classical therapies for inflammatory disorders have demonstrated protective effects in various models of cardiovascular disease; especially established drugs with pleiotropic immunomodulatory properties have proven beneficial cardiovascular effects; normalization of oxidative stress seems to be a common feature of these therapies. The close link between inflammation and redox balance was also supported by reports on aggravated inflammatory phenotype in the absence of antioxidant defense proteins (e.g., superoxide dismutases, heme oxygenase-1, and glutathione peroxidases) or overexpression of reactive oxygen species producing enzymes (e.g., NADPH oxidases). The value of immunomodulation for the treatment of cardiovascular disease was recently supported by large-scale clinical trials demonstrating reduced cardiovascular mortality in patients with established atherosclerotic disease when treated by highly specific anti-inflammatory therapies (e.g., using monoclonal antibodies against cytokines). Modern antidiabetic cardiovascular drugs (e.g., SGLT2 inhibitors, DPP-4 inhibitors, and GLP-1 analogs) seem to share these immunomodulatory properties and display potent antioxidant effects, all of which may explain their successful lowering of cardiovascular risk.

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Metadata

Authors
Steven, S., Frenis, K., Oelze, M., Kalinovic, S., Kuntic, M., Bayo Jimenez, M. T., Vujacic-Mirski, K., Helmstädter, J., Kröller-Schön, S., Münzel, T., & Daiber, A.
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2019-06-23
Volume
2019
Pages
1-26
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
DOI
10.1155/2019/7092151
OpenAlex
W2951345394
Cited by
708
References
281
FWCI
23.47
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease. https://app.cochat.ai/papers/10.1155/2019/7092151
The paper
Steven, S., Frenis, K., Oelze, M., Kalinovic, S., Kuntic, M., Bayo Jimenez, M. T., Vujacic-Mirski, K., Helmstädter, J., Kröller-Schön, S., Münzel, T., & Daiber, A. (2019). Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2019/7092151

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.