The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases
Open accessAbstract
Under normal physiological conditions, reactive oxygen species (ROS) are produced through redox reactions as byproducts of respiratory and metabolic activities. However, due to various endogenous and exogenous factors, the body may produce excessive ROS, which leads to oxidative stress (OS). Numerous studies have shown that OS causes a variety of pathological changes in cells, including mitochondrial dysfunction, DNA damage, telomere shortening, lipid peroxidation, and protein oxidative modification, all of which can trigger apoptosis and senescence. OS also induces a variety of aging-related diseases, such as retinal disease, neurodegenerative disease, osteoarthritis, cardiovascular diseases, cancer, ovarian disease, and prostate disease. In this review, we aim to introduce the multiple internal and external triggers that mediate ROS levels in rodents and humans as well as the relationship between OS, aging, and aging-related diseases. Finally, we present a statistical analysis of effective antioxidant measures currently being developed and applied in the field of aging research.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.001 · Cited by 2,654
Cellular mechanisms and physiological consequences of redox-dependent signalling
Holmström, K. M., & Finkel, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3801 · Cited by 2,093
Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · cited 1×
“OS also accelerates organismal aging through the release of inflammatory cytokines [62], downregulation of immune function and regenerative capacity [63], induction of transcriptomic changes associated with the aging process [57], and inhibition of multiple oxidase activities [54].”
BackgroundConcept, mechanism, and applications of phenolic antioxidants in foods
Zeb, A. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13394 · Cited by 862
Redox Regulation of NF-kappa B Activation
Flohé, L., Brigelius-Flohé, R., Saliou, C., Traber, M. G., & Packer, L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00501-1 · Cited by 859
ROS/oxidative stress signaling in osteoarthritis
Lepetsos, P., & Papavassiliou, A. G. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.01.003 · Cited by 801
Kirkwood, T. B. L. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00419-5 · Cited by 799
Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease
Steven, S., Frenis, K., Oelze, M., Kalinovic, S., Kuntic, M., Bayo Jimenez, M. T., Vujacic-Mirski, K., Helmstädter, J., Kröller-Schön, S., Münzel, T., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7092151 · Cited by 708
Oxidative Stress and Antioxidants in Neurodegenerative Disorders
Olufunmilayo, E. O., Gerke-Duncan, M. B., & Holsinger, R. M. D. (2023) · Antioxidants · doi:10.3390/antiox12020517 · Cited by 670
Cited by
Haykal, D., Lim, H. W., Calzavara-Pinton, P., Fluhr, J., Cartier, H., & Berardesca, E. (2025) · JAAD Reviews · doi:10.1016/j.jdrv.2025.05.001 · Cited by 16
Hushpulian, D. M., Kaidery, N. A., Soni, P., Poloznikov, A. A., Zakhariants, A. A., Razumovskaya, A. V., Silkina, M. O., Tishkov, V. I., Kazakov, E. H., Brown, A. M., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103794 · Cited by 8
Metadata
- Authors
- Yang, J., Luo, J., Tian, X., Zhao, Y., Li, Y., & Wu, X.
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2024-03-25
- Volume
- 13
- Issue
- 4
- Pages
- 394
- ISSN
- 2076-3921 (ISSN-L)
- OpenAlex
- W4393164278
- Cited by
- 259
- References
- 83
- FWCI
- 44.03
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases. https://app.cochat.ai/papers/10.3390/antiox13040394
- The paper
- Yang, J., Luo, J., Tian, X., Zhao, Y., Li, Y., & Wu, X. (2024). Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases. Antioxidants. https://doi.org/10.3390/antiox13040394
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
