The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing
Open accessAbstract
Mesenchymal stem cell transplantation (MSCT) promotes cutaneous wound healing. Numerous studies have shown that the therapeutic effects of MSCT appear to be mediated by paracrine signaling. However, the cell-cell interaction during MSCT between MSCs and macrophages in the region of cutaneous wound healing is still unknown. In this study, early depletion of macrophages delayed the wound repair with MSC injection, which suggested that MSC-mediated wound healing required macrophages. Moreover, we demonstrated that systemically infused bone marrow MSCs (BMMSCs) and jaw bone marrow MSCs (JMMSCs) could translocate to the wound site, promote macrophages toward M2 polarization, and enhance wound healing.In vitro coculture of MSCs with macrophages enhanced their M2 polarization. Mechanistically, we found that exosomes derived from MSCs induced macrophage polarization and depletion of exosomes of MSCs reduced the M2 phenotype of macrophages. Infusing MSCs without exosomes led to lower number of M2 macrophages at the wound site along with delayed wound repair. We further showed that the miR-223, derived from exosomes of MSCs, regulated macrophage polarization by targeting pknox1. These findings provided the evidence that MSCT elicits M2 polarization of macrophages and may accelerate wound healing by transferring exosome-derived microRNA.
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Cites
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“RELM-α is a well-known marker for M2 macrophages [21, 22] and macrophages showing the woundhealing phenotype [23].”
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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
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Macrophage plasticity and polarization in tissue repair and remodelling
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“Although widely recognized as the contributors of the early inflammatory response, monocytes and macrophages also contribute to angiogenesis, wound contraction, and tissue remodeling, which are required in the wound-healing process [5, 6].”
Mesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis
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Differential Roles of Macrophages in Diverse Phases of Skin Repair
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“The inflammatory response is a crucial component of cutaneous wound healing, as evidenced by severely delayed repair following in vivomacrophage ablation [6].”
Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration
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Cited by
Kou, M., Huang, L., Yang, J., Chiang, Z., Chen, S., Liu, J., Guo, L., Zhang, X., Zhou, X., Xu, X., et al. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05034-x · Cited by 640
Immunomodulatory properties of mesenchymal stromal cells: an update
Müller, L., Tunger, A., Wobus, M., von Bonin, M., Towers, R., Bornhäuser, M., Dazzi, F., Wehner, R., & Schmitz, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.637725 · Cited by 205
Ma, Z.-J., Yang, J.-J., Lu, Y.-B., Liu, Z.-Y., & Wang, X.-X. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i8.814 · Cited by 155
Peshkova, M., Korneev, A., Suleimanov, S., Vlasova, I. I., Svistunov, A., Kosheleva, N., & Timashev, P. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03381-w · Cited by 75
Applications of mesenchymal stem cell-exosome components in wound infection healing: new insights
Fakouri, A., Razavi, Z.-S., Mohammed, A. T., Hussein, A. H. A., Afkhami, H., & Hooshiar, M. H. (2024) · Burns & Trauma · doi:10.1093/burnst/tkae021 · Cited by 69
Metadata
- Authors
- He, X., Dong, Z., Cao, Y., Wang, H., Liu, S., Liao, L., Jin, Y., Yuan, L., & Li, B.
- Venue
- Stem Cells International
- Publisher
- Wiley
- Published
- 2019-09-09
- Volume
- 2019
- Pages
- 1-16
- ISSN
- 1687-966X (ISSN-L)
- 1687-9678
- OpenAlex
- W2972642636
- Cited by
- 404
- References
- 46
- FWCI
- 24.32
- Type
- journal article
- Language
- en
- Open access
- gold
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- He, X., Dong, Z., Cao, Y., Wang, H., Liu, S., Liao, L., Jin, Y., Yuan, L., & Li, B. (2019). MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing. Stem Cells International. https://doi.org/10.1155/2019/7132708
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