Applications of mesenchymal stem cell-exosome components in wound infection healing: new insights
Open accessAbstract
The healing process at a wound is made up of many types of cells, growth factors, the extracellular matrix, nerves and blood vessels all interacting with each other in complex and changing ways. Microbial colonization and proliferation are possible at the place of injury, which makes infection more likely. Because of this, any cut has a chance of getting an infection. Researchers have found that wound infections make patients more upset and cost the healthcare system a lot of money. Surgical site infections happen a lot to people who have recently had surgery. This study shows that such surgical infection is linked to a high rate of illness and death. This is shown by the fact that 25% of patients get serious sepsis and need to be transferred to an intensive care unit. In both animal models and people, mesenchymal stem cells (MSCs) play an active role in all stages of wound healing and have positive effects. Exosomes are one of the main things MSCs release. They have effects that are similar to those of the parent MSCs. Various effector proteins, messenger RNA and microRNAs can be transported by extracellular vesicles to control the activity of target cells. This has a big impact on the healing process. These results suggest that using MSC-exosomes as a new type of cell-free therapy could be a better and safer option than whole cell therapy. This review is mostly about how to use parts of MSC-exosomes to help wound infections heal.
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In multiple myeloma, senescence is involved in various aspects of disease development, immune imbalance, and tumor characteristics.
“In the context of MM, senescence is involved in various aspects of disease development, immune imbalance, and tumor characteristics.”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [258]
The Review section on exosome components implicated in wound infection healing mentions senescence-associated activity in osteoarthritis, not multiple myeloma. Searches for multiple myeloma and senescence found no passage linking senescence to myeloma development, immune imbalance, or tumor characteristics in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredMultiple myeloma is linked to immunometabolic irregularities associated with immunosenescence, leading to advanced aging and an inflammatory immune reaction known as inflammaging, which influences disease advancement.
“Additionally, MM is linked to immunometabolic irregularities associated with immunosenescence, leading to advanced aging and an inflammatory immune reaction known as inflammaging, which influences disease advancement [257, 258].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [258]
The Review sections on wound infection healing and bacterial wound infection discuss how stem-cell exosomes affect inflammation and senescence-associated activity, but not multiple myeloma. Searches for multiple myeloma, immunometabolic irregularities, immunosenescence, and inflammaging found no passage linking those concepts to disease progression. No page numbers were provided for the indexed passages. (LLM, conf=0.76)
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- Authors
- Fakouri, A., Razavi, Z.-S., Mohammed, A. T., Hussein, A. H. A., Afkhami, H., & Hooshiar, M. H.
- Affiliations
- Lorestan University of Medical Sciences (IR)
- Iran University of Medical Sciences (IR)
- Al Noor University College (IQ)
- Ahl Al Bayt University (IQ)
- Shahed University (IR)
- Tehran University of Medical Sciences (IR)
- Corresponding author
- Afkhami, Hamed
- Hooshiar, Mohammad Hosseini
- ORCID
- Venue
- Burns & Trauma
- Publisher
- Oxford University Press (OUP)
- Published
- 2024-01-01
- Volume
- 12
- Pages
- tkae021-tkae021
- ISSN
- 2321-3868 (ISSN-L)
- 2321-3876
- PMC
- PMC11319788
- OpenAlex
- W4401595880
- Cited by
- 69
- References
- 162
- Citations by year
- 2026: 15 · 2025: 41 · 2024: 13
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Burns & Trauma (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- mesenchymal stem cells, exosomes, wound infection, surgical site infection, wound healing, cell-free therapy, extracellular vesicles, microRNA, sepsis, burn wounds
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