Cited by 69Extracellular vesicles in diseaseWound Healing and TreatmentsMesenchymal stem cell research

Applications of mesenchymal stem cell-exosome components in wound infection healing: new insights

Open access
Fakouri, Arshia, Razavi, Zahra-Sadat, Mohammed, Adil Tawfeeq, Hussein, Abbas Hameed Abdul, Afkhami, Hamed, Hooshiar, Mohammad Hosseini·2024·Burns & Trauma

Abstract

The healing process at a wound is made up of many types of cells, growth factors, the extracellular matrix, nerves and blood vessels all interacting with each other in complex and changing ways. Microbial colonization and proliferation are possible at the place of injury, which makes infection more likely. Because of this, any cut has a chance of getting an infection. Researchers have found that wound infections make patients more upset and cost the healthcare system a lot of money. Surgical site infections happen a lot to people who have recently had surgery. This study shows that such surgical infection is linked to a high rate of illness and death. This is shown by the fact that 25% of patients get serious sepsis and need to be transferred to an intensive care unit. In both animal models and people, mesenchymal stem cells (MSCs) play an active role in all stages of wound healing and have positive effects. Exosomes are one of the main things MSCs release. They have effects that are similar to those of the parent MSCs. Various effector proteins, messenger RNA and microRNAs can be transported by extracellular vesicles to control the activity of target cells. This has a big impact on the healing process. These results suggest that using MSC-exosomes as a new type of cell-free therapy could be a better and safer option than whole cell therapy. This review is mostly about how to use parts of MSC-exosomes to help wound infections heal.

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Crossref · 10.1093/burnst/tkae021

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160 of 160 references verified0 citation errors · 0 not checkable

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  • In multiple myeloma, senescence is involved in various aspects of disease development, immune imbalance, and tumor characteristics.

    “In the context of MM, senescence is involved in various aspects of disease development, immune imbalance, and tumor characteristics.”

    From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [258]

    The Review section on exosome components implicated in wound infection healing mentions senescence-associated activity in osteoarthritis, not multiple myeloma. Searches for multiple myeloma and senescence found no passage linking senescence to myeloma development, immune imbalance, or tumor characteristics in our copy. (LLM, conf=0.76)

    Experimental — accuracy not yet measured
  • Multiple myeloma is linked to immunometabolic irregularities associated with immunosenescence, leading to advanced aging and an inflammatory immune reaction known as inflammaging, which influences disease advancement.

    “Additionally, MM is linked to immunometabolic irregularities associated with immunosenescence, leading to advanced aging and an inflammatory immune reaction known as inflammaging, which influences disease advancement [257, 258].”

    From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [258]

    The Review sections on wound infection healing and bacterial wound infection discuss how stem-cell exosomes affect inflammation and senescence-associated activity, but not multiple myeloma. Searches for multiple myeloma, immunometabolic irregularities, immunosenescence, and inflammaging found no passage linking those concepts to disease progression. No page numbers were provided for the indexed passages. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Cites

3 retracted

Flagged first, then by citations

2 of the 162 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

  1. [35]Mahmoudvand G, Karimi Rouzbahani A, Razavi ZS, Mahjoor M, Afkhami H. Afkhami HJFib, biotechnology. Mesenchymal stem cell therapy for non-healing diabetic foot ulcer infection: new insight. 2023; 11: 1158484. PMC10133463 37122856
  2. [51]Fordjour FK, Daaboul GG, Gould SJ. A shared pathway of exosome biogenesis operates at plasma and endosome membranes. BioRxiv. 2019; 545228.
  3. [68]Huang Y, Liu L, Wu J, Li Y. Physiological role of circulating exosomes on hepatic lipid metabolism disorder in ketosis dairy cows. Chinese Journal of Animal Nutrition. 2019; 31: 3004– 8.
  4. [134]Zahm JM, Kaplan H, Hérard AL, Doriot F, Pierrot D, Somelette P, et al. Cell migration and proliferation during the in vitro wound repair of the respiratory epithelium. Cell Motil Cytoskeleton. 1997; 37: 33– 43. 9142437

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Authors
Fakouri, A., Razavi, Z.-S., Mohammed, A. T., Hussein, A. H. A., Afkhami, H., & Hooshiar, M. H.
Affiliations
  • Lorestan University of Medical Sciences (IR)
  • Iran University of Medical Sciences (IR)
  • Al Noor University College (IQ)
  • Ahl Al Bayt University (IQ)
  • Shahed University (IR)
  • Tehran University of Medical Sciences (IR)
Corresponding author
  • Afkhami, Hamed
  • Hooshiar, Mohammad Hosseini
Venue
Burns & Trauma
Published
2024-01-01
Volume
12
Pages
tkae021-tkae021
ISSN
  • 2321-3868 (ISSN-L)
  • 2321-3876
OpenAlex
W4401595880
Cited by
69
References
162
Citations by year
2026: 15 · 2025: 41 · 2024: 13
FWCI
2.82
Type
journal article
Language
en
Open access
Locations
  • Burns & Trauma (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
mesenchymal stem cells, exosomes, wound infection, surgical site infection, wound healing, cell-free therapy, extracellular vesicles, microRNA, sepsis, burn wounds

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