The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Exosomes Derived from Human Bone Marrow Mesenchymal Stem Cells Stimulated by Deferoxamine Accelerate Cutaneous Wound Healing by Promoting Angiogenesis
Open accessAbstract
The exosomes are derived from mesenchymal stem cells (MSCs) and may be potentially used as an alternative for cell therapy, for treating diabetic wounds, and aid in angiogenesis. This study, aimed to investigate whether exosomes originated from bone marrow-derived MSCs (BMSCs) preconditioned by deferoxamine (DFO-Exos) exhibited superior proangiogenic property in wound repair and to explore the underlying mechanisms involved. Human umbilical vein endothelial cells (HUVECs) were used for assays involving cell proliferation, scratch wound healing, and tube formation. To test the effects in vivo, streptozotocin-induced diabetic rats were established. Two weeks after the procedure, histological analysis was used to measure wound-healing effects, and the neovascularization was evaluated as well. Our findings demonstrated that DFO-Exos activate the PI3K/AKT signaling pathway via miR-126 mediated PTEN downregulation to stimulate angiogenesis in vitro. This contributed to enhanced wound healing and angiogenesis in streptozotocin-induced diabetic rats in vivo. Our results suggest that, in cell-free therapies, exosomes derived from DFO preconditioned stem cells manifest increased proangiogenic ability.
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Han, Y., Ren, J., Bai, Y., Pei, X., & Han, Y. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.01.017 · Cited by 320
Cited by
Clinical applications of stem cell-derived exosomes
Tan, F., Li, X., Wang, Z., Li, J., Shahzad, K., & Zheng, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01704-0 · Cited by 708
Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing
Zhou, C., Zhang, B., Yang, Y., Jiang, Q., Li, T., Gong, J., Tang, H., & Zhang, Q. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03345-0 · Cited by 341
Zhao, D., Yu, Z., Li, Y., Wang, Y., Li, Q., & Han, D. (2020) · Journal of Molecular Histology · doi:10.1007/s10735-020-09877-6 · Cited by 139
Metadata
- Authors
- Ding, J., Wang, X., Chen, B., Zhang, J., & Xu, J.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2019-05-05
- Volume
- 2019
- Pages
- 1-12
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W2944806358
- Cited by
- 184
- References
- 1
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- hybrid
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- Ding, J., Wang, X., Chen, B., Zhang, J., & Xu, J. (2019). Exosomes Derived from Human Bone Marrow Mesenchymal Stem Cells Stimulated by Deferoxamine Accelerate Cutaneous Wound Healing by Promoting Angiogenesis. BioMed Research International. https://doi.org/10.1155/2019/9742765
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
