The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing
Open accessAbstract
Wound healing is a dynamic and highly sequential process involving a series of overlapping spatial and temporal phases, including hemostasis, inflammation, proliferation, and tissue remodeling. Mesenchymal stem cells (MSCs) are multipotent stem cells with self-renewal, multidirectional differentiation potential, and paracrine regulation. Exosomes are subcellular vesicular components 30–150 nm in size and are novel carriers of intercellular communication in regulating the biological behaviors of skin cells. Compared to MSCs, MSC-derived exosomes (MSC-exos) possess lower immunogenicity, easy storage, and highly effective biological activity. MSC-exos, mainly derived from adipose-derived stem cells (ADSCs), bone marrow-derived MSCs (BMSCs), human umbilical cord MSCs (hUC-MSCs), and other stem cell types, play a role in shaping the activity of fibroblasts, keratinocytes, immune cells, and endothelial cells in diabetic wounds, inflammatory wound repair, and even wound-related keloid formation. Therefore, this study focuses on the specific roles and mechanisms of different MSC-exos in wound healing, as well as the current limitations and various perspectives. Deciphering the biological properties of MSC-exos is crucial to providing a promising cell-free therapeutic tool for wound healing and cutaneous regeneration. Graphical Abstract
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Cites
3 retracted
Ding, J., Wang, X., Chen, B., Zhang, J., & Xu, J. (2019) · BioMed Research International · doi:10.1155/2019/9742765 · Cited by 184
RetractedShen, C., Tao, C., Zhang, A., Li, X., Guo, Y., Wei, H., Yin, Q., Li, Q., & Jin, P. (2021) · Bioengineered · doi:10.1080/21655979.2021.1997077 · Cited by 55
RetractedKnight, R. J., Emma Board-Davies, Brown, H. L., Clayton, A., Davis, T., Karatas, B., Burston, J. J., Tabi, Z., Falcón‐Pérez, J. M., Paisey, S. J., et al. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szac037 · Cited by 25
RetractedThe biology , function , and biomedical applications of exosomes
Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770
Cellular and molecular mechanisms of repair in acute and chronic wound healing
Martin, P., & Nunan, R. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13954 · Cited by 1,127
Stem cell-based therapy for human diseases
Hoang, D. M., Pham, P. T., Bach, T. Q., Ngo, A. T. L., Nguyen, Q. T., Phan, T. T. K., Nguyen, G. H., Le, P. T. T., Hoang, V. T., Forsyth, N. R., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01134-4 · Cited by 1,074
Falanga, V., Isseroff, R. R., Soulika, A. M., Romanelli, M., Margolis, D., Kapp, S., Granick, M., & Harding, K. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00377-3 · Cited by 1,020
Wang, C., Wang, M., Xu, T., Zhang, X., Lin, C., Gao, W., Xu, H., Lei, B., & Mao, C. (2019) · Theranostics · doi:10.7150/thno.29766 · Cited by 908
Zhang, J., Guan, J., Niu, X., Hu, G., Guo, S., Li, Q., Xie, Z., Zhang, C., & Wang, Y. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0417-0 · Cited by 778
Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake
Kimiz-Gebologlu, I., & Oncel, S. S. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.027 · Cited by 722
Cited by
Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments
Li, G., Wan, Y., Jiao, A., Jiang, K., Cui, G., Tang, J., Yu, S., Hu, Z., Zhao, S., Yi, Z., et al. (2025) · Med Research · doi:10.1002/mdr2.70007 · Cited by 63
Self-citationDomaszewska-Szostek, A., Krzyżanowska, M., Polak, A., & Puzianowska-Kuźnicka, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052354 · Cited by 32
Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration
Deng, L., Liu, Y., Wu, Q., Lai, S., Yang, Q., Mu, Y., & Dong, M. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04024-4 · Cited by 32
Metadata
- Authors
- Zhou, C., Zhang, B., Yang, Y., Jiang, Q., Li, T., Gong, J., Tang, H., & Zhang, Q.
- Venue
- Stem Cell Research & Therapy
- Published
- 2023-04-26
- Volume
- 14
- Issue
- 1
- Pages
- 107-107
- ISSN
- 1757-6512 (ISSN-L)
- OpenAlex
- W4367174431
- Cited by
- 341
- References
- 111
- FWCI
- 25.48
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhou, C., Zhang, B., Yang, Y., Jiang, Q., Li, T., Gong, J., Tang, H., & Zhang, Q. (2023). Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing. Stem Cell Research & Therapy. https://doi.org/10.1186/s13287-023-03345-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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