The ANGPTL8 rs2278426 (C/T) polymorphism is associated with prediabetes and type 2 diabetes in a han Chinese population in Hebei province
Open accessAbstract
Background. Our aim was to investigate the association between the genetics of the angiopoietin protein-like 8 (ANGPTL8) rs2278426 (C/T) polymorphism with prediabetes (pre-DM) and type 2 diabetes (T2DM) in a Han Chinese population in Hebei Province, China. Methods. We enrolled 1,460 participants into this case-control study: healthy controls, n = 524; pre-DM, n = 460; and T2DM: n = 460. Ligase assays on blood samples from all participants were used to identify polymorphisms. Differences in genotype and allele distributions were compared by the chi-square test and one-way analysis of variance, and a post hoc pairwise analysis was performed using the Bonferroni test. The logistic regression technique was adjusted for age, sex, and body mass index. Results. The frequency of the TT (10.9%) genotype was significantly higher in pre-DM patients than in controls (odds ratio [OR] = 1.696, 95% confidence interval [CI] = 1.026–2.802, P = 0.039 ). In the T2DM group, the CT (48%) and TT (15%) genotypes were significantly higher compared with those in the control group (CT : OR = 1.384, 95% CI = 1.013–1.890, P = 0.041 ; TT : OR = 2.530, 95% CI = 1.476–4.334, P = 0.001 ). The frequency of the T allele was significantly higher in the pre-DM (32.8%) and T2DM (39%) groups compared with the control group (26.9%) and was significantly associated with an increased risk of pre-DM (OR = 1.253, 95% CI = 1.017–1.544, P = 0.034 ) and T2DM (OR = 1.518, 95% CI = 1.214–1.897, P = 0.001 ). Furthermore, insulin levels in the pre-DM and T2DM groups were significantly decreased in those with the TT genotype compared with the CC and CT genotypes. Conclusion. ANGPTL8 rs2278426 may be involved in the mechanism of insulin secretion and could lead to an increased risk of pre-DM and T2DM.
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Angptl8 is a hepatokine related to the reset of diurnal rhythms of the hepatic clock and metabolic genes in mice.
“Angptl8 is a hepatokine related to the reset of diurnal rhythms of hepatic clock, and metabolic genes in mice [88,90,91].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [91]
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Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions
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- Authors
- Hou, G., Tang, Y., Ren, L., Guan, Y., Hou, X., & Song, G.
- Affiliations
- Hebei Medical University (CN)
- Hebei General Hospital (CN)
- Corresponding author
- Song, Guangyao
- Venue
- International Journal of Endocrinology
- Publisher
- Wiley
- Published
- 2020-12-02
- Volume
- 2020
- Pages
- 1-8
- ISSN
- 1687-8337 (ISSN-L)
- 1687-8345
- PMC
- PMC7728483
- OpenAlex
- W3106550434
- Cited by
- 11
- References
- 48
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 1
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- ANGPTL8, prediabetes, type 2 diabetes, genetic susceptibility, Han Chinese, insulin resistance, insulin sensitivity, insulin secretion, genetic association
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