The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
The Role of Inflammation in the Pathogenesis of Osteoarthritis
Open accessAbstract
A joint is the point of connection between two bones in our body. Inflammation of the joint leads to several diseases, including osteoarthritis, which is the concern of this review. Osteoarthritis is a common chronic debilitating joint disease mainly affecting the elderly. Several studies showed that inflammation triggered by factors like biomechanical stress is involved in the development of osteoarthritis. This stimulates the release of early-stage inflammatory cytokines like interleukin-1 beta (IL-1 β), which in turn induces the activation of signaling pathways, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κ B), phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), and mitogen-activated protein kinase (MAPK). These events, in turn, generate more inflammatory molecules. Subsequently, collagenase like matrix metalloproteinases-13 (MMP-13) will degrade the extracellular matrix. As a result, anatomical and physiological functions of the joint are altered. This review is aimed at summarizing the previous studies highlighting the involvement of inflammation in the pathogenesis of osteoarthritis.
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Cites
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The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis
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The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
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Cited by
The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases
Cabral-Pacheco, G. A., Garza-Veloz, I., Castruita-De la Rosa, C., Ramirez-Acuña, J. M., Perez-Romero, B. A., Guerrero-Rodriguez, J. F., Martinez-Avila, N., & Martinez-Fierro, M. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249739 · Cited by 1,820
Metadata
- Authors
- Chow, Y. Y., & Chin, K.-Y.
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2020-03-03
- Volume
- 2020
- Pages
- 1-19
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- OpenAlex
- W3009853031
- Cited by
- 523
- References
- 94
- FWCI
- 47.04
- Type
- journal article
- Language
- en
- Open access
- gold
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