Renoprotective Effects of Origanum majorana Methanolic L and Carvacrol on Ischemia/Reperfusion‐Induced Kidney Injury in Male Rats
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Background. The most important cause of acute renal failure in normal kidneys is ischemia‐reperfusion (I/R) injury. The aim of the current study was to investigate the protective effects of Origanum majorana (OM) methanolic extract, carvacrol, and vitamin E on I/R‐induced kidney injury in male rats. Material and Method. Thirty Wistar male rats were randomly allocated into 5 groups; sham, I/R, I/R + OM (300 mg/kg), I/R + carvacrol (75 mg/kg), and I/R + vitamin E (100 mg/kg). Renal function markers, oxidant‐antioxidant parameters, and histopathological examination were evaluated. Results. It was exhibited that the urea, creatinine, protein carbonyl, glomerular filtration rate, total thiol, ferric reducing antioxidant power, and histopathological changes markedly reversed in the treatment groups with OM or carvacrol in comparison to the I/R merely group. Conclusion. We conclude that OM extract or its ingredient, carvacrol, exerts renoprotective impacts in I/R‐induced kidney injury possibly by scavenging free radicals and increasing antioxidant power.
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Increased oxidative stress is a major driver of senescence.
“Increased oxidative stress (OS) is a further major driver of senescence [16,17,18,19,20,21].”
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- Authors
- Gheitasi, I., Azizi, A., Omidifar, N., & Doustimotlagh, A. H.
- Affiliations
- Yasuj University of Medical Sciences (IR)
- Shiraz University of Medical Sciences (IR)
- Corresponding author
- Doustimotlagh, Amir Hossein
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2020-01
- Volume
- 2020
- Issue
- 1
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- OpenAlex
- W3097940375
- Cited by
- 22
- References
- 41
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 2
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Yasuj University of Medical Sciences (960605)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- Origanum majorana, carvacrol, methanol extract, ischemia-reperfusion injury, acute kidney injury, renal protection, vitamin E, oxidative stress, antioxidant capacity, free radical scavenging, renal function markers, protein carbonyls, sulfhydryl groups, ferric reducing antioxidant power
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