Cited by 1,094Epigenetics and DNA MethylationGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

Genome Regulation by Polycomb and Trithorax: 70 Years and Counting

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Schuettengruber, Bernd, Bourbon, Henri-Marc, Di Croce, Luciano, Cavalli, Giacomo·2017·Cell

Abstract

Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-modifying factors originally identified as part of an epigenetic cellular memory system that maintains repressed or active gene expression states. Recently, they have been shown to globally control a plethora of cellular processes. This functional diversity is achieved by their ability to regulate chromatin at multiple levels, ranging from modifying local chromatin structure to orchestrating the three-dimensional organization of the genome. Understanding this system is a fascinating challenge of critical relevance for biology and medicine, since misexpression or mutation of multiple PcG components, as well as of TrxG members of the COMPASS family and of the SWI/SNF complex, is implicated in cancer and other diseases.

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Crossref · 10.1016/j.cell.2017.08.002

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  • Maintenance of gene expression states often relies on many chromatin cofactors not specific to DNA sequence, which set up and maintain chromatin states across cell division and for long periods, sometimes without the original transcription factors.

    “The maintenance phase often involves a plethora of non-DNA sequence specific chromatin cofactors that set up and maintain chromatin states through cell division and for extended periods of time-sometimes in the absence of the initial transcription factors 3 .”

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Research works printed but not linked: 3

  1. Beringer, M., Pisano, P., Di Carlo, V., Blanco, E., Chammas, P., Viza ´ n, P., Gutie ´ rrez, A., Aranda, S., Payer, B., Wierer, M., and Di Croce, L. (2016). http://refhub.elsevier.com/S0092-8674(1730890-5/sref14)
  2. Lewis, P.H. (1947). New mutants report. Drosoph. Inf. Serv. 21 , 69. http://refhub.elsevier.com/S0092-8674(1730890-5/sref128)
  3. Tolhuis, B., de Wit, E., Muijrers, I., Teunissen, H., Talhout, W., van Steensel, B., and van Lohuizen, M. (2006). Genome-wide profiling of PRC1 and PRC2 Polycombchromatinbinding in Drosophila melanogaster. Nat. Genet. 38 , 694-699. http://refhub.elsevier.com/S0092-8674(1730890-5/sref221)

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Authors
Schuettengruber, B., Bourbon, H.-M., Di Croce, L., & Cavalli, G.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
  • Schuettengruber, Bernd
  • Cavalli, Giacomo
Venue
Cell
Publisher
Elsevier BV
Published
2017-09
Volume
171
Issue
1
Pages
34-57
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2760742318
Cited by
1,094
References
246
Citations by year
2026: 80 · 2025: 101 · 2024: 129 · 2023: 134 · 2022: 152 · 2021: 159 · 2020: 147 · 2019: 106 · 2018: 77 · 2017: 8
FWCI
8.64
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
Funders
  • Spanish “Ministerio de Educación y Ciencia” (BFU2016-75008-P)
  • AGAUR
  • La Marato TV3
  • CNRS
  • FP7 European Network of Excellence EpiGeneSys
  • European Union (676556)
  • Agence Nationale de la Recherche (ANR-15-CE12-0006-01)
  • Fondation pour la Recherche Médicale (N. 144186)
  • INSERM
  • ITMO Cancer
  • Laboratory of Excellence EpiGenMed
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
Polycomb group proteins, Trithorax group proteins, chromatin regulation, epigenetic memory, SWI/SNF complex, 3D genome organization, chromatin structure, cancer, gene expression inhibition
MeSH terms
Animals, Chromosomal Proteins, Non-Histone, Gene Expression Regulation, Humans, Neoplasms, Genome, History, 20th Century, History, 21st Century, Embryonic Stem Cells, Polycomb-Group Proteins

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