Genome Regulation by Polycomb and Trithorax: 70 Years and Counting
Open accessAbstract
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-modifying factors originally identified as part of an epigenetic cellular memory system that maintains repressed or active gene expression states. Recently, they have been shown to globally control a plethora of cellular processes. This functional diversity is achieved by their ability to regulate chromatin at multiple levels, ranging from modifying local chromatin structure to orchestrating the three-dimensional organization of the genome. Understanding this system is a fascinating challenge of critical relevance for biology and medicine, since misexpression or mutation of multiple PcG components, as well as of TrxG members of the COMPASS family and of the SWI/SNF complex, is implicated in cancer and other diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Maintenance of gene expression states often relies on many chromatin cofactors not specific to DNA sequence, which set up and maintain chromatin states across cell division and for long periods, sometimes without the original transcription factors.
“The maintenance phase often involves a plethora of non-DNA sequence specific chromatin cofactors that set up and maintain chromatin states through cell division and for extended periods of time-sometimes in the absence of the initial transcription factors 3 .”
From Advances in epigenetics link genetics to the environment and disease (2019) · cites this paper as [3]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
Rao, S. S. P., Huntley, M. H., Durand, N. C., Stamenova, E. K., Bochkov, I. D., Robinson, J. T., Sanborn, A. L., Machol, I., Omer, A. D., Lander, E. S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.021 · Cited by 9,212 · see citing works
Topological domains in mammalian genomes identified by analysis of chromatin interactions
Dixon, J. R., Selvaraj, S., Yue, F., Kim, A., Li, Y., Shen, Y., Hu, M., Liu, J. S., & Ren, B. (2012) · Nature · doi:10.1038/nature11082 · Cited by 6,829 · see citing works
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361 · see citing works
A gene complex controlling segmentation in Drosophila
Lewis, E. B. (1978) · Nature · doi:10.1038/276565a0 · Cited by 3,813 · see citing works
The Polycomb complex PRC2 and its mark in life
Margueron, R., & Reinberg, D. (2011) · Nature · doi:10.1038/nature09784 · Cited by 3,347 · see citing works
Spatial partitioning of the regulatory landscape of the X-inactivation centre
Nora, E. P., Lajoie, B. R., Schulz, E. G., Giorgetti, L., Okamoto, I., Servant, N., Piolot, T., van Berkum, N. L., Meisig, J., Sedat, J., et al. (2012) · Nature · doi:10.1038/nature11049 · Cited by 2,895 · see citing works
The polycomb group protein EZH2 is involved in progression of prostate cancer
Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., et al. (2002) · Nature · doi:10.1038/nature01075 · Cited by 2,717 · see citing works
The accessible chromatin landscape of the human genome
Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679 · see citing works
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Boyer, L. A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T. I., Levine, S. S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,518 · see citing works
Three-dimensional folding and functional organization principles of the Drosophila genome
Sexton, T., Yaffe, E., Kenigsberg, E., Bantignies, F., Leblanc, B., Hoichman, M., Parrinello, H., Tanay, A., & Cavalli, G. (2012) · Cell · doi:10.1016/j.cell.2012.01.010 · Cited by 1,983 · see citing works
Self-citationA long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
Wang, K., Yang, Y. W., Liu, B., Sanyal, A., Corces, M. R., Chen, Y., Lajoie, B. R., Protacio, A., Flynn, R. A., Gupta, R. A., et al. (2011) · Nature · doi:10.1038/nature09819 · Cited by 1,963 · see citing works
Transgenerational epigenetic inheritance: myths and mechanisms
Heard, E., & Martienssen, R. A. (2014) · Cell · doi:10.1016/j.cell.2014.02.045 · Cited by 1,864 · see citing works
Morin, R. D., Johnson, N. A., Severson, T., Mungall, A. J. J., An, J., Goya, R., Paul, J. E., Boyle, M., Woolcock, B. W., Kuchenbauer, F. C., et al. (2010) · Nature Genetics · doi:10.1038/ng.518 · Cited by 1,670 · see citing works
Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A., & van Lohuizen, M. (1999) · Nature · doi:10.1038/16476 · Cited by 1,580 · see citing works
Genome Regulation by Polycomb and Trithorax Proteins
Schuettengruber, B., Chourrout, D. M., Vervoort, M., Leblanc, B., & Cavalli, G. (2007) · Cell · doi:10.1016/j.cell.2007.02.009 · Cited by 1,433 · see citing works
Self-citationInhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
Lewis, P. W., Müller, M. M., Koletsky, M. S., Cordero, F., Lin, S., Banaszynski, L. A., Garcia, B. A., Muir, T. W., Becher, O. J., & Allis, C. D. (2013) · Science · doi:10.1126/science.1232245 · Cited by 1,345 · see citing works
Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals
Sharma, U., Conine, C. C., Shea, J. M., Boskovic, A., Derr, A. G., Bing, X. Y., Belleannee, C., Kucukural, A., Serra, R. W., Sun, F., et al. (2016) · Science · doi:10.1126/science.aad6780 · Cited by 1,275 · see citing works
Role of the polycomb protein EED in the propagation of repressive histone marks
Margueron, R., Justin, N., Ohno, K., Sharpe, M. L., Son, J., Drury, W. J., Voigt, P., Martin, S. R., Taylor, W. R., Marco, V. D., et al. (2009) · Nature · doi:10.1038/nature08398 · Cited by 1,203 · see citing works
Role of Histone H3 Lysine 27 Methylation in X Inactivation
Plath, K., Fang, J., Mlynarczyk‐Evans, S., Cao, R., Worringer, K. A., Wang, H., de la Cruz, C. C., Otte, A. P., Panning, B., & Zhang, Y. (2003) · Science · doi:10.1126/science.1084274 · Cited by 1,190 · see citing works
Organization and function of the 3D genome
Bonev, B., & Cavalli, G. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.112 · Cited by 1,174 · see citing works
Self-citationBmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARFPreprint
Jacobs, J. J. L., Scheijen, B., Voncken, J. W., Kieboom, K., Berns, A. J. M., & van Lohuizen, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2678 · Cited by 1,060 · see citing works
Javierre, B. M., Burren, O. S., Wilder, S. P., Kreuzhuber, R., Hill, S. M., Sewitz, S., Cairns, J., Wingett, S. W., Várnai, C., Thiecke, M. J., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.037 · Cited by 1,046 · see citing works
Shen, X., Liu, Y., Hsu, Y.-J., Fujiwara, Y., Kim, J., Mao, X., Yuan, G.-C., & Orkin, S. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.016 · Cited by 1,021 · see citing works
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains
Ku, M., Koche, R. P., Rheinbay, E., Mendenhall, E. M., Endoh, M., Mikkelsen, T. S., Aiden, A. P., Nusbaum, C., Xie, X. S., Chi, A. S., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000242 · Cited by 996 · see citing works
Fischle, W., Wang, Y., Jacobs, S. A., Kim, Y., Allis, C. D., & Khorasanizadeh, S. (2003) · Genes & Development · doi:10.1101/gad.1110503 · Cited by 993 · see citing works
Vernalization requires epigenetic silencing of FLC by histone methylation
Bastow, R., Mylne, J. S., Lister, C., Lippman, Z. B., Martienssen, R. A., & Dean, C. (2004) · Nature · doi:10.1038/nature02269 · Cited by 977 · see citing works
Tamkun, J. W., Deuring, R., Scott, M. P., Kissinger, M., Pattatucci, A. M. L., Kaufman, T. C., & Kennison, J. A. (1992) · Cell · doi:10.1016/0092-8674(92)90191-e · Cited by 966 · see citing works
Systematic Protein Location Mapping Reveals Five Principal Chromatin Types in Drosophila Cells
Filion, G. J. P., van Bemmel, J. G., Braunschweig, U., Talhout, W., Kind, J., Ward, L. D., Brugman, W., de Castro, I. J., Kerkhoven, R. M., Bussemaker, H. J., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.009 · Cited by 963 · see citing works
MicroRNA-mediated conversion of human fibroblasts to neurons
Yoo, A. S., Sun, A. X., Li, L., Shcheglovitov, A., Portmann, T., Li, Y., Lee-Messer, C., Dolmetsch, R. E., Tsien, R. W., & Crabtree, G. R. (2011) · Nature · doi:10.1038/nature10323 · Cited by 919 · see citing works
Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms
Margueron, R., Li, G., Sarma, K., Blais, A., Zavadil, J., Woodcock, C. L. F., Dynlacht, B. D., & Reinberg, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.11.004 · Cited by 889 · see citing works
Super-resolution imaging reveals distinct chromatin folding for different epigenetic states
Boettiger, A. N., Bintu, B., Moffitt, J. R., Wang, S. S., Beliveau, B. J., Fudenberg, G., Imakaev, M., Mirny, L. A., Wu, C.-T., & Zhuang, X. (2016) · Nature · doi:10.1038/nature16496 · Cited by 877 · see citing works
Polycomb silencing mechanisms and the management of genomic programmes
Schwartz, Y. B., & Pirrotta, V. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1981 · Cited by 868 · see citing works
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
Kharchenko, P. V., Alekseyenko, A. A., Schwartz, Y. B., Minoda, A., Riddle, N. C., Ernst, J., Sabo, P. J., Larschan, E., Gorchakov, A. A., Gu, T., et al. (2010) · Nature · doi:10.1038/nature09725 · Cited by 853 · see citing works
Role of Bmi-1 and Ring1A in H2A Ubiquitylation and Hox Gene Silencing
Cao, R., Tsukada, Y.-I., & Zhang, Y. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.12.002 · Cited by 847 · see citing works
Kadoch, C., & Crabtree, G. R. (2015) · Science Advances · doi:10.1126/sciadv.1500447 · Cited by 843 · see citing works
Stabilization of Chromatin Structure by PRC1, a Polycomb Complex
Shao, Z., Raible, F., Mollaaghababa, R., Guyon, J. R., Wu, C.-T., Bender, W. W., & Kingston, R. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80604-2 · Cited by 821 · see citing works
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
Scheuermann, J. C., Alonso, A. G. D. A., Oktaba, K., Ly‐Hartig, N., McGinty, R. K., Fraterman, S., Wilm, M. S., Muir, T. W., & Müller, J. (2010) · Nature · doi:10.1038/nature08966 · Cited by 816 · see citing works
Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination
Lee, M. G., Villa, R., Trojer, P., Norman, J. A., Yan, K.-P., Reinberg, D., Croce, L. D., & Shiekhattar, R. (2007) · Science · doi:10.1126/science.1149042 · Cited by 772 · see citing works
Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos
Liu, X., Wang, C., Liu, W., Li, J., Li, C., Kou, X., Chen, J., Zhao, Y., Gao, H., Wang, H., et al. (2016) · Nature · doi:10.1038/nature19362 · Cited by 746 · see citing works
Blackledge, N. P., Farcas, A. M., Kondo, T., King, H. W., McGouran, J. F., Hanssen, L. L. P., Ito, S., Cooper, S., Kondo, K., Koseki, Y., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.004 · Cited by 734 · see citing works
Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks
Schmitges, F. W., Prusty, A. B., Faty, M., Stützer, A., Lingaraju, G. M., Aiwazian, J., Sack, R., Heß, D., Li, L., Zhou, S., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.025 · Cited by 725 · see citing works
A model for transmission of the H3K27me3 epigenetic mark
Hansen, K. H., Bracken, A. P., Pasini, D., Dietrich, N., Gehani, S. S., Monrad, A., Rappsilber, J., Lerdrup, M., & Helin, K. (2008) · Nature Cell Biology · doi:10.1038/ncb1787 · Cited by 720 · see citing works
Khavari, P. A., Peterson, C. L., Tamkun, J. W., Mendel, D. B., & Crabtree, G. R. (1993) · Nature · doi:10.1038/366170a0 · Cited by 670 · see citing works
Stock, J. K., Giadrossi, S., Casanova, M., Brookes, E., Vidal, M., Koseki, H., Brockdorff, N., Fisher, A. G., & Pombo, A. (2007) · Nature Cell Biology · doi:10.1038/ncb1663 · Cited by 650 · see citing works
Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27Preprint
Min, J., Zhang, Y., & Xu, R.-M. (2003) · Genes & Development · doi:10.1101/gad.269603 · Cited by 649 · see citing works
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
Dahl, J. A., Jung, I., Aanes, H., Greggains, G. D., Manaf, A., Lerdrup, M., Li, G., Kuan, S., Li, B., Lee, A. Y., et al. (2016) · Nature · doi:10.1038/nature19360 · Cited by 628 · see citing works
Allelic reprogramming of the histone modification H3K4me3 in early mammalian development
Zhang, B., Zheng, H., Huang, B., Li, W., Xiang, Y.-L., Peng, X., Jia, M., Wu, X., Zhang, Y., Xu, Q.-H., et al. (2016) · Nature · doi:10.1038/nature19361 · Cited by 627 · see citing works
CpG islands influence chromatin structure via the CpG-binding protein Cfp1
Thomson, J. P., Skene, P. J., Selfridge, J., Clouaire, T., Guy, J., Webb, S., Kerr, A. R. W., Deaton, A., Andrews, R., James, K. D., et al. (2010) · Nature · doi:10.1038/nature08924 · Cited by 625 · see citing works
Lee, W., Teckie, S., Wiesner, T., Ran, L., Granada, C. N. P., Lin, M., Zhu, S., Cao, Z., Liang, Y., Sboner, A., et al. (2014) · Nature Genetics · doi:10.1038/ng.3095 · Cited by 618 · see citing works
Genome-wide analysis of Polycomb targets in Drosophila melanogaster
Schwartz, Y. B., Kahn, T. G., Nix, D. A., Li, X., Bourgon, R., Biggin, M. D., & Pirrotta, V. (2006) · Nature Genetics · doi:10.1038/ng1817 · Cited by 610 · see citing works
Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells
Ezhkova, E., Pasolli, H. A., Parker, J. S., Stokes, N., Su, I.-H., Hannon, G. J., Tarakhovsky, A., & Fuchs, E. V. (2009) · Cell · doi:10.1016/j.cell.2008.12.043 · Cited by 599 · see citing works
der Poel, S. Z.-V., McCabe, N. R., Gill, H. J., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10735 · Cited by 594 · see citing works
CBP-mediated acetylation of histone H3 lysine 27 antagonizesDrosophilaPolycomb silencing
Tie, F., Banerjee, R., Stratton, C. A., Prasad-Sinha, J., Stepanik, V. A., Zlobin, A., Dı́az, M. O., Scacheri, P. C., & Harte, P. J. (2009) · Development · doi:10.1242/dev.037127 · Cited by 575 · see citing works
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
Pasini, D., Cloos, P. A., Walfridsson, J., Olsson, L., Bukowski, J., Johansen, J. V., Bak, M., Tommerup, N., Rappsilber, J., & Helin, K. (2010) · Nature · doi:10.1038/nature08788 · Cited by 562 · see citing works
Hierarchical Recruitment of Polycomb Group Silencing Complexes
Wang, L., Brown, J. L., Cao, R., Zhang, Y., Kassis, J. A., & Jones, R. S. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.009 · Cited by 562 · see citing works
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development
Yoo, A. S., Staahl, B. T., Chen, L., & Crabtree, G. R. (2009) · Nature · doi:10.1038/nature08139 · Cited by 537 · see citing works
H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation
Yuan, W., Xu, M., Huang, C., Liu, N., Chen, S., & Zhu, B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.194027 · Cited by 537 · see citing works
Narendra, V., Rocha, P. P., An, D., Raviram, R., Skok, J. A., Mazzoni, E. O., & Reinberg, D. (2015) · Science · doi:10.1126/science.1262088 · Cited by 535 · see citing works
Bernstein, E., Duncan, E. M., Masui, O., Gil, J., Heard, É., & Allis, C. D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.7.2560-2569.2006 · Cited by 531 · see citing works
Epigenetic balance of gene expression by Polycomb and COMPASS families
Piunti, A., & Shilatifard, A. (2016) · Science · doi:10.1126/science.aad9780 · Cited by 524 · see citing works
Disruption of histone methylation in developing sperm impairs offspring health transgenerationally
Siklenka, K., Erkek, S., Godmann, M., Lambrot, R., McGraw, S., Lafleur, C., Cohen, T., Xia, J., Suderman, M., Hallett, M., et al. (2015) · Science · doi:10.1126/science.aab2006 · Cited by 521 · see citing works
Polycomb-Dependent H3K27me1 and H3K27me2 Regulate Active Transcription and Enhancer Fidelity
Ferrari, K. J., Scelfo, A., Jammula, S., Cuomo, A., Barozzi, I., Stützer, A., Fischle, W., Bonaldi, T., & Pasini, D. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.030 · Cited by 507 · see citing works
Jarid2 and PRC2, partners in regulating gene expressionPreprint
Li, G., Margueron, R., Ku, M., Chambon, P., Bernstein, B., & Reinberg, D. (2010) · Genes & Development · doi:10.1101/gad.1886410 · Cited by 499 · see citing works
McCabe, M. T., Graves, A. P., Ganji, G., Diaz, E., Halsey, W. S., Jiang, Y., Smitheman, K. N., Ott, H. M., Pappalardi, M. B., Allen, K. E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116418109 · Cited by 493 · see citing works
A Polycomb-based switch underlying quantitative epigenetic memory
Angel, A., Song, J., Dean, C., & Howard, M. (2011) · Nature · doi:10.1038/nature10241 · Cited by 478 · see citing works
Bmi1 regulates mitochondrial function and the DNA damage response pathway
Liu, J., Cao, L., Chen, J., Song, S., Lee, I. H., Quijano, C., Liu, H., Keyvanfar, K., Chen, H., Cao, L.-Y., et al. (2009) · Nature · doi:10.1038/nature08040 · Cited by 474 · see citing works
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
Farcas, A. M., Blackledge, N. P., Sudbery, I. M., Long, H. K., McGouran, J. F., Rose, N. R., Lee, S., Sims, D., Cerase, A., Sheahan, T. W., et al. (2012) · eLife · doi:10.7554/elife.00205 · Cited by 472 · see citing works
Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila.
Kennison, J. A., & Tamkun, J. W. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.8136 · Cited by 469 · see citing works
A trithorax–like gene is interrupted by chromosome 11q23 translocations in acute leukaemias
Djabali, M., Selleri, L., Parry, P. J., Bower, M., Young, B. D., & Evans, G. A. (1992) · Nature Genetics · doi:10.1038/ng1092-113 · Cited by 468 · see citing works
Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression
Kalb, R., Latwiel, S., Baymaz, H. I., Jansen, P. W. T. C., Müller, C. W., Vermeulen, M., & Müller, J. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2833 · Cited by 451 · see citing works
De novo DNA methylation: a germ cell perspective
Smallwood, S. A., & Kelsey, G. (2012) · Trends in Genetics · doi:10.1016/j.tig.2011.09.004 · Cited by 448 · see citing works
Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas
Piunti, A., Hashizume, R., Morgan, M. A., Bartom, E. T., Horbinski, C. M., Marshall, S. A., Rendleman, E. J., Ma, Q., Takahashi, Y.-H., Woodfin, A. R., et al. (2017) · Nature Medicine · doi:10.1038/nm.4296 · Cited by 445 · cited 2× · see citing works
“Although this was initially correlated to the capacity of H3K27me2/3 to strongly bind and sequester the PRC2 complex, recent data seem to support a model in which H3K27M excludes PRC2 binding, facilitating an aberrant accumulation of acetylated H3K27 (Figure 7A) on the other wildtype copies of histone H3 in heterotypi…”
Chromatin proteins and modifications as drug targets
Helin, K., & Dhanak, D. (2013) · Nature · doi:10.1038/nature12751 · Cited by 435 · see citing works
Resetting Epigenetic Memory by Reprogramming of Histone Modifications in Mammals
Zheng, H., Huang, B., Zhang, B., Xiang, Y., Du, Z., Xu, Q., Li, Y., Wang, Q., Ma, J., Xu, P., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.032 · Cited by 432 · see citing works
Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila
Bantignies, F., Roure, V., Comet, I., Leblanc, B., Schuettengruber, B., Bonnet, J., Tixier, V., Mas, A., & Cavalli, G. (2011) · Cell · doi:10.1016/j.cell.2010.12.026 · Cited by 429 · see citing works
Self-citationMaintaining cell identity: PRC2-mediated regulation of transcription and cancer
Comet, I. V., Riising, E. M., Leblanc, B., & Helin, K. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.83 · Cited by 428 · see citing works
Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells
Shen, X., Kim, W., Fujiwara, Y., Simon, M. D., Liu, Y., Mysliwiec, M. R., Yuan, G., Lee, Y., & Orkin, S. H. (2009) · Cell · doi:10.1016/j.cell.2009.12.003 · Cited by 426 · see citing works
GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells
Mendenhall, E. M., Koche, R. P., Truong, T. T., Zhou, V. W., Issac, B., Chi, A. S., Ku, M., & Bernstein, B. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001244 · Cited by 412 · see citing works
The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in CancerPreprint
Hodges, H. C., Kirkland, J. G., & Crabtree, G. R. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026930 · Cited by 411 · see citing works
Zhou, W., Zhu, P., Wang, J., Pascual, G., Ohgi, K. A., Lozach, J., Glass, C. K., & Rosenfeld, M. G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.11.002 · Cited by 407 · see citing works
Two distinct modes for propagation of histone PTMs across the cell cyclePreprint
Alabert, C., Barth, T. K., Reverón-Gómez, N., Sidoli, S., Schmidt, A., Jensen, O. N., Imhof, A., & Groth, A. (2015) · Genes & Development · doi:10.1101/gad.256354.114 · Cited by 404 · see citing works
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
Justin, N., Zhang, Y., Tarricone, C., Martin, S. R., Chen, S., Underwood, E., Marco, V. D., Haire, L. F., Walker, P. A., Reinberg, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms11316 · Cited by 403 · see citing works
Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide
Riising, E. M., Comet, I. V., Leblanc, B., Wu, X., Johansen, J. V., & Helin, K. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.005 · Cited by 402 · see citing works
Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2
Jiao, L., & Liu, X. (2015) · Science · doi:10.1126/science.aac4383 · Cited by 402 · see citing works
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
Schoenfelder, S., Sugar, R., Dimond, A., Javierre, B.-M., Armstrong, H., Mifsud, B., Dimitrova, E., Matheson, L., Tavares-Cadete, F., Furlan-Magaril, M., et al. (2015) · Nature Genetics · doi:10.1038/ng.3393 · Cited by 398 · see citing works
Papp, B., & Müller, J. (2006) · Genes & Development · doi:10.1101/gad.388706 · Cited by 397 · see citing works
Klymenko, T., Papp, B., Fischle, W., Köcher, T., Schelder, M., Fritsch, C., Wild, B., Wilm, M. S., & Müller, J. (2006) · Genes & Development · doi:10.1101/gad.377406 · Cited by 397 · see citing works
The Dynamic Architecture of Hox Gene Clusters
Noordermeer, D., Leleu, M., Splinter, E., Rougemont, J., de Laat, W. L., & Duboule, D. (2011) · Science · doi:10.1126/science.1207194 · Cited by 391 · see citing works
Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster
Tolhuis, B., Muijrers, I., de Wit, E., Teunissen, H., Talhout, W., van Steensel, B., & van Lohuizen, M. (2006) · Nature Genetics · doi:10.1038/ng1792 · Cited by 380 · see citing works
Kanhere, A., Viiri, K. M., Araújo, C. C., Rasaiyaah, J., Bouwman, R. D., Whyte, W. A., Pereira, C., Brookes, E., Walker, K., Bell, G. W., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.019 · Cited by 370 · see citing works
Targeting Polycomb systems to regulate gene expression: modifications to a complex story
Blackledge, N. P., Rose, N. R., & Klose, R. J. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4067 · Cited by 370 · see citing works
The Drosophila Fab-7 Chromosomal Element Conveys Epigenetic Inheritance during Mitosis and Meiosis
Cavalli, G., & Paro, R. (1998) · Cell · doi:10.1016/s0092-8674(00)81181-2 · Cited by 367 · see citing works
Self-citationThe super elongation complex (SEC) and MLL in development and diseasePreprint
Smith, E. R., Lin, C., & Shilatifard, A. (2011) · Genes & Development · doi:10.1101/gad.2015411 · Cited by 362 · see citing works
The Murine Polycomb Group Protein Eed Is Required for Global Histone H3 Lysine-27 Methylation
Montgomery, N. D., Yee, D., Chen, A., Kalantry, S., Chamberlain, S. J., Otte, A. P., & Magnuson, T. (2005) · Current Biology · doi:10.1016/j.cub.2005.04.051 · Cited by 345 · see citing works
Kundu, S., Ji, F., Sunwoo, H., Jain, G., Lee, J. T., Sadreyev, R. I., Dekker, J., & Kingston, R. E. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.01.009 · Cited by 333 · see citing works
Functional Anatomy of Polycomb and Trithorax Chromatin Landscapes in Drosophila Embryos
Schuettengruber, B., Ganapathi, M., Leblanc, B., Portoso, M., Jaschek, R., Tolhuis, B., van Lohuizen, M., Tanay, A., & Cavalli, G. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000013 · Cited by 331 · see citing works
Self-citationElements of the Drosophila Bithorax Complex That Mediate Repression by Polycomb Group Products
Simon, J. A., Chiang, A., Bender, W. W., Shimell, M., & O’Connor, M. B. (1993) · Developmental Biology · doi:10.1006/dbio.1993.1174 · Cited by 325 · see citing works
Nonoverlapping Functions of the Polycomb Group Cbx Family of Proteins in Embryonic Stem Cells
Morey, L., Pascual, G., Cozzuto, L., Roma, G., Wutz, A., Benitah, S. A., & Croce, L. D. (2012) · Cell stem cell · doi:10.1016/j.stem.2011.12.006 · Cited by 324 · see citing works
Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome
McGinty, R. K., Henrici, R. C., & Tan, S. (2014) · Nature · doi:10.1038/nature13890 · Cited by 324 · see citing works
Terranova, R., Yokobayashi, S., Stadler, M. B., Otte, A. P., van Lohuizen, M., Orkin, S. H., & Peters, A. H. F. M. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.08.015 · Cited by 324 · see citing works
Cooper, S., Dienstbier, M., Hassan, R., Schermelleh, L., Sharif, J., Blackledge, N. P., Marco, V. D., Elderkin, S., Koseki, H., Klose, R. J., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.012 · Cited by 323 · see citing works
An AUTS2–Polycomb complex activates gene expression in the CNS
Gao, Z., Lee, P., Stafford, J. M., von Schimmelmann, M. J., Schaefer, A., & Reinberg, D. (2014) · Nature · doi:10.1038/nature13921 · Cited by 323 · see citing works
Xie, H., Xu, J., Hsu, J. H.-R., Nguyen, M., Fujiwara, Y., Peng, C., & Orkin, S. H. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.10.001 · Cited by 320 · see citing works
SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing.
Isono, K., Endo, T. A., Ku, M., Yamada, D., Suzuki, R., Sharif, J., Ishikura, T., Toyoda, T., Bernstein, B., & Koseki, H. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.08.016 · Cited by 320 · see citing works
Essential Role of the Glycosyltransferase Sxc/Ogt in Polycomb Repression
Gambetta, M. C., Oktaba, K., & Müller, J. (2009) · Science · doi:10.1126/science.1169727 · Cited by 315 · see citing works
Polycomb complexes in stem cells and embryonic development
Aloia, L., Stefano, B. D., & Croce, L. D. (2013) · Development · doi:10.1242/dev.091553 · Cited by 314 · see citing works
RNAi Components Are Required for Nuclear Clustering of Polycomb Group Response Elements
Grimaud, C., Bantignies, F., Pal‐Bhadra, M., Ghana, P., Bhadra, U., & Cavalli, G. (2006) · Cell · doi:10.1016/j.cell.2006.01.036 · Cited by 312 · see citing works
Self-citationPRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells
Kaneko, S., Son, J., Shen, S. S., Reinberg, D., & Bonasio, R. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2700 · Cited by 308 · see citing works
A Histone Mutant Reproduces the Phenotype Caused by Loss of Histone-Modifying Factor Polycomb
Pengelly, A. R., Copur, Ö., Jäckle, H., Herzig, A., & Müller, J. (2013) · Science · doi:10.1126/science.1231382 · Cited by 297 · see citing works
Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts
Victor, M. B., Richner, M., Hermanstyne, T. O., Ransdell, J. L., Sobieski, C., Deng, P.-Y., Klyachko, V. A., Nerbonne, J. M., & Yoo, A. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.016 · Cited by 295 · see citing works
The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2
Davidovich, C., & Cech, T. R. (2015) · RNA · doi:10.1261/rna.053918.115 · Cited by 295 · see citing works
Dense Chromatin Activates Polycomb Repressive Complex 2 to Regulate H3 Lysine 27 Methylation
Yuan, W., Wu, T., Fu, H., Dai, C., Wu, H., Liu, N., Li, X., Xu, M., Zhang, Z., Niu, T., et al. (2012) · Science · doi:10.1126/science.1225237 · Cited by 292 · see citing works
Denissov, S., Hofemeister, H., Marks, H., Kranz, A., Ciotta, G., Singh, S., Anastassiadis, K., Stunnenberg, H. G., & Stewart, A. F. (2014) · Development · doi:10.1242/dev.102681 · Cited by 292 · see citing works
Saurin, A. J., Shiels, C., Williamson, J. A., Satijn, D. P. E., Otte, A. P., Sheer, D., & Freemont, P. S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.4.887 · Cited by 291 · see citing works
Dynamics of BAF–Polycomb complex opposition on heterochromatin in normal and oncogenic states
Kadoch, C., Williams, R. T., Calarco, J. P., Miller, E. L., Weber, C. M., Braun, S. M. G., Pulice, J. L., Chory, E. J., & Crabtree, G. R. (2016) · Nature Genetics · doi:10.1038/ng.3734 · Cited by 291 · see citing works
Lanzuolo, C., Roure, V., Dekker, J., Bantignies, F., & Orlando, V. (2007) · Nature Cell Biology · doi:10.1038/ncb1637 · Cited by 289 · see citing works
Regulatory Interactions between RNA and Polycomb Repressive Complex 2
Cifuentes‐Rojas, C., Hernandez, A. J., Sarma, K., & Lee, J. T. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.009 · Cited by 286 · see citing works
Ezh2 Requires PHF1 To Efficiently Catalyze H3 Lysine 27 Trimethylation In Vivo
Sarma, K., Margueron, R., Ivanov, A. V., Pirrotta, V., & Reinberg, D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02017-07 · Cited by 286 · see citing works
PCGF3/5–PRC1 initiates Polycomb recruitment in X chromosome inactivation
Almeida, M. R., Pintacuda, G., Masui, O., Koseki, Y., Gdula, M. R., Cerase, A., Brown, D., Mould, A. W., Innocent, C., Nakayama, M., et al. (2017) · Science · doi:10.1126/science.aal2512 · Cited by 284 · see citing works
Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila.
Struhl, G., & Akam, M. E. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04075.x · Cited by 281 · see citing works
A High-Density Map for Navigating the Human Polycomb Complexome
Hauri, S., Comoglio, F., Seimiya, M., Gerstung, M., Glatter, T., Hansen, K. H., Aebersold, R. H., Paro, R., Gstaiger, M., & Beisel, C. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.096 · Cited by 281 · see citing works
Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state
Crevillén, P., Yang, H., Cui, X., Greeff, C., Trick, M., Qiu, Q., Cao, X., & Dean, C. (2014) · Nature · doi:10.1038/nature13722 · Cited by 280 · see citing works
Pcl‐PRC2 is needed to generate high levels of H3‐K27 trimethylation at Polycomb target genes
Nekrasov, M., Klymenko, T., Fraterman, S., Papp, B., Oktaba, K., Köcher, T., Cohen, A., Stunnenberg, H. G., Wilm, M. S., & Müller, J. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601837 · Cited by 280 · see citing works
Mozzetta, C., Pontis, J., Fritsch, L., Robin, P., Portoso, M., Proux, C., Margueron, R., & Ait‐Si‐Ali, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.005 · Cited by 278 · see citing works
Cell differentiation and morphogenesis in the colony-forming choanoflagellate Salpingoeca rosetta
Dayel, M. J., Alegado, R. A., Fairclough, S. R., Levin, T. C., Nichols, S. A., McDonald, K., & King, N. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.06.003 · Cited by 277 · see citing works
Secombe, J., Li, L., Carlos, L. S., & Eisenman, R. N. (2007) · Genes & Development · doi:10.1101/gad.1523007 · Cited by 277 · see citing works
Brookes, E., de Santiago, I., Hebenstreit, D., Morris, K. J., Carroll, T., Xie, S. Q., Stock, J. K., Heidemann, M., Eick, D., Nozaki, N., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2011.12.017 · Cited by 276 · see citing works
Denholtz, M., Bonora, G., Chronis, C., Splinter, E., de Laat, W., Ernst, J., Pellegrini, M., & Plath, K. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.08.013 · Cited by 274 · see citing works
Cooper, S., Grijzenhout, A., Underwood, E., Ancelin, K., Zhang, T., Nesterova, T. B., Kirmizitas, B. A., Bassett, A. R., Kooistra, S. M., Agger, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms13661 · Cited by 272 · see citing works
MLL2 Is Required in Oocytes for Bulk Histone 3 Lysine 4 Trimethylation and Transcriptional Silencing
Andreu‐Vieyra, C., Chen, R., Agno, J. E., Glaser, S. P., Anastassiadis, K., Stewart, A. F., & Matzuk, M. M. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000453 · Cited by 270 · see citing works
H3K27me and PRC2 transmit a memory of repression across generations and during development
Gaydos, L. J., Wang, W., & Strome, S. (2014) · Science · doi:10.1126/science.1255023 · Cited by 268 · see citing works
Klymenko, T., & Müller, J. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400111 · Cited by 268 · see citing works
dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencingPreprint
Lagarou, A., Mohd-Sarip, A., Moshkin, Y. M., Chalkley, G. E., Bezstarosti, K., Demmers, J., & Verrijzer, C. P. (2008) · Genes & Development · doi:10.1101/gad.484208 · Cited by 260 · see citing works
Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high chargePreprint
Grau, D., Chapman, B., Garlick, J. D., Borowsky, M. L., Francis, N. J., & Kingston, R. E. (2011) · Genes & Development · doi:10.1101/gad.17288211 · Cited by 252 · see citing works
Inheritance of Polycomb-dependent chromosomal interactions in DrosophilaPreprint
Bantignies, F., Grimaud, C., Lavrov, S. A., Gabut, M., & Cavalli, G. (2003) · Genes & Development · doi:10.1101/gad.269503 · Cited by 250 · see citing works
Self-citationvan Lohuizen, M., Frasch, M., Wientjens, E., & Berns, A. J. M. (1991) · Nature · doi:10.1038/353353a0 · Cited by 248 · see citing works
Molecular architecture of human polycomb repressive complex 2
Ciferri, C., Lander, G. C., Maiolica, A., Herzog, F., Aebersold, R. H., & Nogales, E. (2012) · eLife · doi:10.7554/elife.00005 · Cited by 246 · see citing works
TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication
Petruk, S., Sedkov, Y., Johnston, D. M., Hodgson, J. W., Black, K. L., Kovermann, S. K., Beck, S., Canaani, E., Brock, H. W., & Mazo, A. (2012) · Cell · doi:10.1016/j.cell.2012.06.046 · Cited by 246 · see citing works
Nakagawa, T., Kajitani, T., Togo, S., Masuko, N., Ohdan, H., Hishikawa, Y., Koji, T., Matsuyama, T., Ikura, T., Muramatsu, M., et al. (2008) · Genes & Development · doi:10.1101/gad.1609708 · Cited by 245 · see citing works
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity
Ballaré, C., Lange, M., Lapinaitė, A., Martín, G. M., Morey, L., Pascual, G., Liefke, R., Simon, B., Shi, Y., Gozani, O., et al. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2434 · Cited by 245 · see citing works
Klauke, K., Radulović, V., Broekhuis, M., Weersing, E., Zwart, E., Olthof, S., Ritsema, M., Bruggeman, S., Wu, X., Helin, K., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2701 · Cited by 237 · see citing works
The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis
Muntean, A. G., Tan, J., Sitwala, K. V., Huang, Y., Bronstein, J. C., Connelly, J. A., Basrur, V., Elenitoba‐Johnson, K. S. J., & Hess, J. L. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.04.012 · Cited by 232 · see citing works
Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis
Milne, T. A., Kim, J., Wang, G. G., Stadler, S. C., Basrur, V., Whitcomb, S. J., Wang, Z., Ruthenburg, A. J., Elenitoba‐Johnson, K. S. J., Roeder, R. G., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.011 · Cited by 231 · see citing works
Dingwall, A. K., Beek, S. J., McCallum, C. M., Tamkun, J. W., Kalpana, G. V., Goff, S. P., & Scott, M. P. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.7.777 · Cited by 225 · see citing works
Hidalgo, I., Herrera-Merchan, A., Ligos, J. M., Carramolino, L., Nuñez, J., Martinez, F., Dominguez, O., Torres, M., & Gonzalez, S. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.08.001 · Cited by 222 · see citing works
The interaction of PRC2 with RNA or chromatin is mutually antagonisticPreprint
Beltran-Nebot, M., Yates, C. M., Skalska, L., Dawson, M., Reis, F. P., Viiri, K. M., Fisher, C. L., Sibley, C. R., Foster, B. M., Bartke, T., et al. (2016) · Genome Research · doi:10.1101/gr.197632.115 · Cited by 221 · see citing works
Causal role for inheritance of H3K27me3 in maintaining the OFF state of a <i>Drosophila</i> HOX gene
Coleman, R. T., & Struhl, G. (2017) · Science · doi:10.1126/science.aai8236 · Cited by 221 · see citing works
Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition
Zenk, F. L., Loeser, E., Schiavo, R., Kilpert, F., Bogdanović, O., & Iovino, N. (2017) · Science · doi:10.1126/science.aam5339 · Cited by 215 · see citing works
The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation
Kloet, S. L., Makowski, M. M., Baymaz, H. I., van Voorthuijsen, L., Karemaker, I. D., Santanach, A., Jansen, P. W. T. C., Croce, L. D., & Vermeulen, M. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3248 · Cited by 210 · see citing works
Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin
Stanton, B. Z., Hodges, H. C., Calarco, J. P., Braun, S. M. G., Ku, W. L., Kadoch, C., Zhao, K., & Crabtree, G. R. (2016) · Nature Genetics · doi:10.1038/ng.3735 · Cited by 204 · see citing works
Yang, Y. W., Flynn, R. A., Chen, Y., Qu, K., Wan, B., Wang, K., Lei, M., & Chang, H. Y. (2014) · eLife · doi:10.7554/elife.02046 · Cited by 201 · see citing works
Transcriptional repression by PRC1 in the absence of H2A monoubiquitylationPreprint
Pengelly, A. R., Kalb, R., Finkl, K., & Müller, J. (2015) · Genes & Development · doi:10.1101/gad.265439.115 · Cited by 200 · see citing works
Chromatin topology is coupled to Polycomb group protein subnuclear organization
Wani, A. H., Boettiger, A. N., Schorderet, P., Ergün, A., Munger, C., Sadreyev, R. I., Zhuang, X., Kingston, R. E., & Francis, N. J. (2016) · Nature Communications · doi:10.1038/ncomms10291 · Cited by 199 · see citing works
Fauvarque, M., & Dura, J. (1993) · Genes & Development · doi:10.1101/gad.7.8.1508 · Cited by 198 · see citing works
Buchenau, P., Hodgson, J. W., Strutt, H. L., & Arndt‐Jovin, D. J. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.2.469 · Cited by 198 · see citing works
Joshi, O., Wang, S.-Y., Kuznetsova, T., Atlasi, Y., Peng, T., Fabre, P. J., Habibi, E., Shaik, J., Saeed, S., Handoko, L., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.11.010 · Cited by 198 · see citing works
Regional control of histone H3 lysine 27 methylation in Neurospora
Jamieson, K., Rountree, M. R., Lewis, Z., Stajich, J., & Selker, E. U. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303750110 · Cited by 196 · see citing works
The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells
Hu, D., Garruss, A. S., Gao, X., Morgan, M. A., Cook, M. E., Smith, E. R., & Shilatifard, A. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2653 · Cited by 195 · see citing works
Blobel, G. A., Kadauke, S., Wang, E., Lau, A. W., Zuber, J. A., Chou, M. M., & Vakoc, C. R. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.12.001 · Cited by 194 · see citing works
Propagation of Polycomb-repressed chromatin requires sequence-specific recruitment to DNA
Laprell, F., Finkl, K., & Müller, J. (2017) · Science · doi:10.1126/science.aai8266 · Cited by 188 · see citing works
PRC2 is dispensable for HOTAIR‐mediated transcriptional repression
Portoso, M., Ragazzini, R., Brenčič, Ž., Moiani, A., Michaud, A., Vassilev, I., Wassef, M. A., Servant, N., Sargueil, B., & Margueron, R. (2017) · The EMBO Journal · doi:10.15252/embj.201695335 · Cited by 187 · see citing works
The Dynamic Regulatory Genome of Capsaspora and the Origin of Animal Multicellularity
Sebé-Pedrós, A., Ballaré, C., Parra-Acero, H., Chiva, C., Tena, J. J., Sabidó, E., Gómez-Skármeta, J. L., Croce, L. D., & Ruiz‐Trillo, I. (2016) · Cell · doi:10.1016/j.cell.2016.03.034 · Cited by 183 · see citing works
Polycomb Proteins Remain Bound to Chromatin and DNA during DNA Replication In Vitro
Francis, N. J., Follmer, N. E., Simon, M. D., Aghia, G., & Butler, J. D. (2009) · Cell · doi:10.1016/j.cell.2009.02.017 · Cited by 181 · see citing works
Polycomb Protein Ezh1 Promotes RNA Polymerase II Elongation
Mousavi, K., Zare, H., Wang, A. H., & Sartorelli, V. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.11.019 · Cited by 180 · see citing works
From genetics to epigenetics: the tale of Polycomb group and trithorax group genes
Grimaud, C., Negre, N. N., & Cavalli, G. (2006) · Chromosome Research · doi:10.1007/s10577-006-1069-y · Cited by 179 · see citing works
Self-citationHyperconserved CpG domains underlie Polycomb-binding sites
Tanay, A., O’Donnell‐Luria, A., Damelin, M. I., & Bestor, T. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609746104 · Cited by 176 · see citing works
CTCF-mediated topological boundaries during development foster appropriate gene regulationPreprint
Narendra, V. K., Bulajić, M., Dekker, J., Mazzoni, E. O., & Reinberg, D. (2016) · Genes & Development · doi:10.1101/gad.288324.116 · Cited by 172 · see citing works
The central role of EED in the orchestration of polycomb group complexes
Cao, Q., Wang, X., Zhao, M., Yang, R., Malik, R., Qiao, Y., Poliakov, A., Yocum, A. K., Li, Y., Chen, W., et al. (2014) · Nature Communications · doi:10.1038/ncomms4127 · Cited by 167 · see citing works
Long range repression conferring boundaries of Ultrabithorax expression in the Drosophila embryo.
Müller, J., & Bienz, M. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04876.x · Cited by 165 · see citing works
Product Binding Enforces the Genomic Specificity of a Yeast Polycomb Repressive Complex
Dumesic, P. A., Homer, C. M., Moresco, J. J., Pack, L. R., Shanle, E. K., Coyle, S. M., Strahl, B. D., Fujimori, D. G., Yates, J. R., & Madhani, H. D. (2014) · Cell · doi:10.1016/j.cell.2014.11.039 · Cited by 165 · see citing works
Brooun, A., Gajiwala, K. S., Deng, Y., Liu, W., Bolaños, B., Bingham, P., He, Y.-A., Diehl, W. C., Grable, N., Kung, P., et al. (2016) · Nature Communications · doi:10.1038/ncomms11384 · Cited by 164 · see citing works
FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3
Jozwik, K. M., Chernukhin, I. V., Sérandour, A. A., Nagarajan, S., & Carroll, J. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.028 · Cited by 164 · see citing works
Ayton, P. M., Chen, E. H., & Cleary, M. L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.23.10470-10478.2004 · Cited by 160 · see citing works
Variable chromatin structure revealed by in situ spatially correlated DNA cleavage mapping
Risca, V. I., Denny, S. K., Straight, A. F., & Greenleaf, W. J. (2016) · Nature · doi:10.1038/nature20781 · Cited by 159 · see citing works
The E3 ubiquitin ligase activity of RING1B is not essential for early mouse developmentPreprint
Illingworth, R. S., Moffat, M., Mann, A. R., Read, D., Hunter, C. J., Pradeepa, M. M., Adams, I. R., & Bickmore, W. A. (2015) · Genes & Development · doi:10.1101/gad.268151.115 · Cited by 157 · see citing works
ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia
Zhu, L., Li, Q., Wong, S. H. K., Huang, M., Klein, B. J., Shen, J., Ikenouye, L., Onishi, M., Schneidawind, D., Buechele, C., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0058 · Cited by 157 · see citing works
Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain
Vieux-Rochas, M., Fabre, P. J., Leleu, M., Duboule, D., & Noordermeer, D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504783112 · Cited by 156 · see citing works
Polycomb preferentially targets stalled promoters of coding and noncoding transcriptsPreprint
Enderle, D., Beisel, C., Stadler, M. B., Gerstung, M., Athri, P., & Paro, R. (2010) · Genome Research · doi:10.1101/gr.114348.110 · Cited by 156 · see citing works
van den Boom, V., Maat, H., Geugien, M., López, A. R., Sotoca, A. M., Jaques, J., Brouwers-Vos, A. Z., Fusetti, F., Groen, R. W. J., Yuan, H., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.12.034 · Cited by 156 · see citing works
Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning
Lau, M. S., Schwartz, M. G., Kundu, S., Savol, A. J., Wang, P. I., Marr, S. K., Grau, D., Schorderet, P., Sadreyev, R. I., Tabin, C. J., et al. (2017) · Science · doi:10.1126/science.aah5403 · Cited by 152 · see citing works
Gene bivalency at Polycomb domains regulates cranial neural crest positional identity
Minoux, M., Holwerda, S. J. B., Vitobello, A., Kitazawa, T., Kohler, H., Stadler, M. B., & Rijli, F. M. (2017) · Science · doi:10.1126/science.aal2913 · Cited by 144 · see citing works
RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes
Rose, N. R., King, H. W., Blackledge, N. P., Fursova, N. A., Ember, K. J., Fischer, R., Kessler, B. M., & Klose, R. J. (2016) · eLife · doi:10.7554/elife.18591 · Cited by 143 · see citing works
Guo, W., Datta, S., Band, V., & Dimri, G. P. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0447 · Cited by 141 · see citing works
Endoh, M., Endo, T. A., Shinga, J., Hayashi, K., Farcas, A. M., Ma, K.-W., Ito, S., Sharif, J., Endoh, T., Onaga, N., et al. (2017) · eLife · doi:10.7554/elife.21064 · Cited by 141 · see citing works
Morey, L., Santanach, A., Blanco, E., Aloia, L., Nora, E. P., Bruneau, B. G., & Croce, L. D. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.08.009 · Cited by 140 · see citing works
EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells
Beringer, M., Pisano, P., Carlo, V. D., Blanco, E., Chammas, P., Vizán, P., Gutiérrez, A., Aranda, S., Payer, B., Wierer, M., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.018 · Cited by 139 · see citing works
Single-molecule decoding of combinatorially modified nucleosomes
Shema, E., Jones, D. R., Noam Shoresh, F., Donohue, L., Ram, O., & Bernstein, B. (2016) · Science · doi:10.1126/science.aad7701 · Cited by 138 · see citing works
Genome-wide activities of Polycomb complexes control pervasive transcriptionPreprint
Lee, H.-G., Kahn, T. G., Simcox, A. A., Schwartz, Y. B., & Pirrotta, V. (2015) · Genome Research · doi:10.1101/gr.188920.114 · Cited by 134 · see citing works
Polycomb function during oogenesis is required for mouse embryonic developmentPreprint
Pósfai, E., Kunzmann, R., Brochard, V., Salvaing, J., Cabuy, E., Roloff, T. C., Liu, Z., Tardat, M., van Lohuizen, M., Vidal, M., et al. (2012) · Genes & Development · doi:10.1101/gad.188094.112 · Cited by 133 · see citing works
Paramutation and related phenomena in diverse species
Hollick, J. B. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.115 · Cited by 132 · see citing works
Chromatin Sampling—An Emerging Perspective on Targeting Polycomb Repressor Proteins
Klose, R. J., Cooper, S., Farcas, A. M., Blackledge, N. P., & Brockdorff, N. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003717 · Cited by 129 · see citing works
Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila
Ciabrelli, F., Comoglio, F., Fellous, S., Bonev, B., Ninova, M., Szabo, Q., Xuéreb, A., Klopp, C., Aravin, A., Paro, R., et al. (2017) · Nature Genetics · doi:10.1038/ng.3848 · Cited by 129 · see citing works
Self-citationSperm is epigenetically programmed to regulate gene transcription in embryosPreprint
Teperek, M., Simeone, A., Gaggioli, V., Miyamoto, K., Allen, G. E., Erkek, S., Kwon, T., Marcotte, E. M., Zegerman, P., Bradshaw, C. R., et al. (2016) · Genome Research · doi:10.1101/gr.201541.115 · Cited by 128 · see citing works
O-GlcNAcylation Prevents Aggregation of the Polycomb Group Repressor Polyhomeotic
Gambetta, M. C., & Müller, J. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.10.020 · Cited by 126 · see citing works
Chiacchiera, F., Rossi, A., Jammula, S., Piunti, A., Scelfo, A., Ordóñez‐Morán, P., Huelsken, J., Koseki, H., & Pasini, D. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.09.019 · Cited by 124 · see citing works
Ingham, P. W. (1983) · Nature · doi:10.1038/306591a0 · Cited by 121 · see citing works
Schaaf, C. A., Misulovin, Z., Gause, M., Koenig, A. N., Gohara, D. W., Watson, A. R., & Dorsett, D. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003560 · Cited by 118 · see citing works
Frangini, A., Sjöberg-Herrera, M. K., Román-Trufero, M., Dharmalingam, G., Haberle, V., Bartke, T., Lenhard, B., Malumbres, M., Vidal, M., & Dillon, N. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.022 · Cited by 117 · see citing works
EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape
Liefke, R., Karwacki-Neisius, V., & Shi, Y. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.019 · Cited by 115 · see citing works
Herzog, V. A., Lempradl, A. M., Trupke, J., Okulski, H., Altmutter, C., Ruge, F., Boidol, B., Kubicek, S., Schmauss, G., Aumayr, K., et al. (2014) · Nature Genetics · doi:10.1038/ng.3058 · Cited by 110 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Beringer, M., Pisano, P., Di Carlo, V., Blanco, E., Chammas, P., Viza ´ n, P., Gutie ´ rrez, A., Aranda, S., Payer, B., Wierer, M., and Di Croce, L. (2016). http://refhub.elsevier.com/S0092-8674(1730890-5/sref14)
- Lewis, P.H. (1947). New mutants report. Drosoph. Inf. Serv. 21 , 69. http://refhub.elsevier.com/S0092-8674(1730890-5/sref128)
- Tolhuis, B., de Wit, E., Muijrers, I., Teunissen, H., Talhout, W., van Steensel, B., and van Lohuizen, M. (2006). Genome-wide profiling of PRC1 and PRC2 Polycombchromatinbinding in Drosophila melanogaster. Nat. Genet. 38 , 694-699. http://refhub.elsevier.com/S0092-8674(1730890-5/sref221)
Cited by
Sorted by citations
Advances in epigenetics link genetics to the environment and disease
Cavalli, G., & Heard, E. (2019) · Nature · doi:10.1038/s41586-019-1411-0 · Cited by 1,509 · see citing works
Self-citationMolecular mechanisms directing PRC2 recruitment and H3K27 methylation
Laugesen, A., Højfeldt, J. W., & Helin, K. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.03.011 · Cited by 602 · see citing works
Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression
Fursova, N. A., Blackledge, N. P., Nakayama, M., Ito, S., Koseki, Y., Farcas, A. M., King, H. W., Koseki, H., & Klose, R. J. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.03.024 · Cited by 267 · see citing works
Hinohara, K., Wu, H.-J., Vigneau, S., McDonald, T. O., Igarashi, K. J., Yamamoto, K. N., Madsen, T., Fassl, A., Egri, S. B., Papanastasiou, M., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.10.014 · Cited by 255 · see citing works
PRC1 catalytic activity is central to polycomb system function
Blackledge, N. P., Fursova, N. A., Kelley, J. R., Huseyin, M. K., Feldmann, A., & Klose, R. J. (2020) · Molecular Cell · doi:10.1016/j.molcel.2019.12.001 · Cited by 243 · see citing works
Metabolic regulation of chromatin modifications and gene expression
Schvartzman, J. M., Thompson, C. B., & Finley, L. W. S. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201803061 · Cited by 233 · see citing works
Inflammation and DNA damage: cause, effect or both
Pezone, A., Olivieri, F., Napoli, M. V., Procopio, A., Avvedimento, E. V., & Gabrielli, A. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00905-1 · Cited by 212 · see citing works
Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells
Rhodes, J. D. P., Feldmann, A., Hernández-Rodríguez, B., Díaz, N., Brown, J. M., Fursova, N. A., Blackledge, N. P., Prathapan, P., Dobrinic, P., Huseyin, M. K., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.057 · Cited by 187 · see citing works
Astolfi, A., Fiore, M., Melchionda, F., Indio, V., Bertuccio, S. N., & Pession, A. (2019) · Epigenomics · doi:10.2217/epi-2018-0195 · Cited by 183 · see citing works
How subtle changes in 3D structure can create large changes in transcription
Xiao, J. Y., Hafner, A., & Boettiger, A. N. (2021) · eLife · doi:10.7554/elife.64320 · Cited by 162 · see citing works
Epigenetics, Development, and Psychopathology
O'Donnell, K. J., & Meaney, M. J. (2020) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095530 · Cited by 94 · see citing works
Histone Lysine Methylation Dynamics Control <i>EGFR</i> DNA Copy-Number Amplification
Clarke, T. L., Tang, R., Chakraborty, D., Van Rechem, C., Ji, F., Mishra, S., Ma, A., Kaniskan, H. Ü., Jin, J., Lawrence, M. S., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0463 · Cited by 50 · see citing works
A, P., Xu, X., Wang, C., Yang, J., Wang, S., Dai, J., & Ye, L. (2018) · Epigenetics & Chromatin · doi:10.1186/s13072-018-0213-1 · Cited by 30 · see citing works
[Retracted] Quercetin Prevents Radiation‐Induced Oral Mucositis by Upregulating BMI‐1
Zhang, J., Hong, Y., Liuyang, Z., Li, H., Jiang, Z., Tao, J., Liu, H., Xie, A., Feng, Y., Dong, X., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/2231680 · Cited by 28 · see citing works
RetractedAlcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation
Meier, S., Cantilena, S., Niklison Chirou, M. V., Anderson, J., Hargrave, D., Salomoni, P., de Boer, J., & Michod, D. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04078-9 · Cited by 15 · see citing works
Epigenetic preparation of future gene induction kinetics
Xiong, J., & Zhu, B. (2025) · Annual Review of Genetics · doi:10.1146/annurev-genet-012825-093148 · Cited by 12 · see citing works
- Authors
- Schuettengruber, B., Bourbon, H.-M., Di Croce, L., & Cavalli, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Schuettengruber, Bernd
- Cavalli, Giacomo
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 171
- Issue
- 1
- Pages
- 34-57
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2760742318
- Cited by
- 1,094
- References
- 246
- Citations by year
- 2026: 80 · 2025: 101 · 2024: 129 · 2023: 134 · 2022: 152 · 2021: 159 · 2020: 147 · 2019: 106 · 2018: 77 · 2017: 8
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Spanish “Ministerio de Educación y Ciencia” (BFU2016-75008-P)
- AGAUR
- La Marato TV3
- CNRS
- FP7 European Network of Excellence EpiGeneSys
- European Union (676556)
- Agence Nationale de la Recherche (ANR-15-CE12-0006-01)
- Fondation pour la Recherche Médicale (N. 144186)
- INSERM
- ITMO Cancer
- Laboratory of Excellence EpiGenMed
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- Polycomb group proteins, Trithorax group proteins, chromatin regulation, epigenetic memory, SWI/SNF complex, 3D genome organization, chromatin structure, cancer, gene expression inhibition
- MeSH terms
- Animals, Chromosomal Proteins, Non-Histone, Gene Expression Regulation, Humans, Neoplasms, Genome, History, 20th Century, History, 21st Century, Embryonic Stem Cells, Polycomb-Group Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review