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Choline Intake Correlates with Cognitive Performance among Elder Adults in the United States

Liu, Lu, Qiao, Song, Zhuang, Liying, Xu, Shanhu, Chen, Linhui, Lai, Qilun, Wang, Wenfeng·2021·Behavioural Neurology
DOI 10.1155/2021/2962245PMC PMC8570899
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Abstract

Objective. This research attempted to explore the neuroprotective effect of choline and establish evidence for future dietary recommendations and nutritional interventions to maintain a proper cognitive function among elders aged >60 years in the US. Method. This cross-sectional study retrieved data of 2,393 eligible elderly participants from the 2011-2014 National Health and Nutrition Examination Survey. Combining dietary and supplement choline intake, total choline intake was evaluated using the 24-hour dietary recall method and the dietary supplement questionnaire. Total choline intake was categorized into tertiles, which ranged at <187.60 mg/day (T1), 187.60-399.50 mg/day (T2), and >399.50 mg/day (T3). The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) Word Learning subtest, Animal Fluency (AF) test, and Digit Symbol Substitution test (DSST) was used to measure cognitive function. Participants who scored the lowest 25th percentile in each cognitive test were classified in the low cognitive function (LC) group. Logistic regression models were implemented to examine the association between total choline intake and the incidence of LC. Results. In the CERAD test, the risk of LC was significantly lower in T2 than T1 (OR: 0.668, 95% CI: 0.493-0.904, and P = 0.006 ) when adjusted for age, gender, BMI, alcohol consumption, and hypertension. Similarly, T2 was associated with a significantly lower risk of LC when assessed by the AF test (OR: 0.606, 95% CI: 0.580-0.724, and P < 0.001 ) and DSST (0.584, 95% CI: 0.515-0.661, and P < 0.001 ). In all three cognitive measures, the T3 of the total choline intake was not associated with cognitive function compared to T1. Conclusion. Total choline intake at 187.06-399.50 mg/day reduces the risk of LC by approximately 50% compared to intake at <187.6 mg/day. The findings of this research may be used to establish dietary recommendations and nutritional interventions to optimize the cognitive function among elders.

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  • Studies have shown benefits of dietary choline intake and supplementation on cognitive performance in human individuals and in animal models.

    “This finding aligns with studies showing benefits of dietary choline intake and supplementation on cognitive performance in human individuals and in animal models71–78.”

    From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [76]

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Cited by

Sorted by citations

Authors
Liu, L., Qiao, S., Zhuang, L., Xu, S., Chen, L., Lai, Q., & Wang, W.
Affiliations
  • Department of Neurology, Zhejiang Hospital, Hangzhou, Zhejiang 310013, China
  • School of Science, Shanghai Institute of Technology, Shanghai 201418, China
ORCID
Venue
Behavioural Neurology
Publisher
Wiley
Published
2021-10-29
Volume
2021
Pages
1-11
ISSN
  • 1875-8584
  • 0953-4180
DOI
10.1155/2021/2962245
PMC
PMC8570899
Cited by
41
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)
Funders
Natural Science Foundation of Zhejiang Province (LQ19H090006)

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