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Neuroprotective Actions of Dietary Choline

Blusztajn, Jan, Slack, Barbara, Mellott, Tiffany·2017·Nutrients
DOI 10.3390/nu9080815PMC PMC5579609
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Abstract

Choline is an essential nutrient for humans. It is a precursor of membrane phospholipids (e.g., phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl group donor S-adenosylmethionine. High choline intake during gestation and early postnatal development in rat and mouse models improves cognitive function in adulthood, prevents age-related memory decline, and protects the brain from the neuropathological changes associated with Alzheimer’s disease (AD), and neurological damage associated with epilepsy, fetal alcohol syndrome, and inherited conditions such as Down and Rett syndromes. These effects of choline are correlated with modifications in histone and DNA methylation in brain, and with alterations in the expression of genes that encode proteins important for learning and memory processing, suggesting a possible epigenomic mechanism of action. Dietary choline intake in the adult may also influence cognitive function via an effect on PC containing eicosapentaenoic and docosahexaenoic acids; polyunsaturated species of PC whose levels are reduced in brains from AD patients, and is associated with higher memory performance, and resistance to cognitive decline.

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  • Studies have shown benefits of dietary choline intake and supplementation on cognitive performance in human individuals and in animal models.

    “This finding aligns with studies showing benefits of dietary choline intake and supplementation on cognitive performance in human individuals and in animal models71–78.”

    From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [75]

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Authors
Blusztajn, J., Slack, B., & Mellott, T.
Affiliations
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
Venue
Nutrients
Publisher
MDPI AG
Published
2017-07-28
Volume
9
Issue
8
Pages
815
ISSN
2072-6643
DOI
10.3390/nu9080815
PMC
PMC5579609
Cited by
254
References
16
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • NIH (AG009525, CA120488)
  • Simons Foundation

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