The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Research Progress on the Relationship between Obesity-Inflammation-Aromatase Axis and Male Infertility
Open accessAbstract
Aromatase is a key enzyme in the transformation of androgen into estrogen. Its high expression will destroy the hormonal balance in the male body, and the excessive transformation of androgen into estrogen in the body will further damage the spermatogenic function of the testis, affect the normal development of the sperm, and cause spermatogenic disturbance. Adipose tissue has a high expression of aromatase and shows high enzymatic activity and ability to convert estrogen. Adipose tissue is the most estrogen‐producing nongonadal tissue in the body because of its large size, accounting for about 20% of the body mass in healthy adults. PPAR γ is recognized as the key adipose differentiation in the transcriptional regulation of the transcription factor. In the process of adipocyte differentiation, PPAR γ regulate the expression of aromatase. The increase of aromatase is associated with the inflammatory response in adipose tissue caused by obesity. After obesity, the increase of proinflammatory factors in adipocytes will lead to enhanced transcription of the CYP19 gene encoding aromatase in adipocytes, which in turn will lead to increased expression of aromatase in adipocytes. This article reviews the regulation of male sterility from the angle of the “obesity‐inflammation‐aromatase” axis.
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“Chronic inflammation associated with obesity, and inflammatory factors (e.g., IL-6 and TNF-α) increase the expression of the Cyp19a1 gene encoding the aromatase enzyme in testicular tissues [43,44].”
From Prevention of Diet-Induced Obesity by Phytoecdysteroids 20-Hydroxyecdysone and Calonysterone—Unexpected Modulation of Androgen Balance in Normal and Obese Rats (2026) · cites this paper as [43]
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Cites
1 retracted
The Prostaglandin Transporter Regulates Adipogenesis and Aromatase Transcription
Subbaramaiah, K., Hudis, C. A., & Dannenberg, A. J. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0367 · Cited by 15
RetractedGrygiel-Górniak, B. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-17 · Cited by 1,079 · cited 1×
“PPARs are members of the nuclear receptor superfamily and have three subtypes, PPARα, PPARβ/δ, and PPARγ, which have the properties of anti-inflammation, anti-TLR4 inflammatory response pathway, and anti-NF-κB [35, 36].”
BackgroundHypoxia and Adipose Tissue Function and Dysfunction in Obesity
Trayhurn, P. (2013) · Physiological Reviews · doi:10.1152/physrev.00017.2012 · Cited by 932 · cited 1×
“It further recruits macrophages to infiltrate adipose tissue, leaving the body in a state of low-grade inflammatory response [16].”
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“The former provides reductive equivalent NADPH+H and electron transfer for hydroxylation catalyzed by P450arom, while the latter provides steroid hormone binding sites for catalytic synthesis of estrogen [22].”
BackgroundLee, B.-C., & Lee, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.017 · Cited by 714 · cited 1×
“Obesity is now accepted as a low-grade, chronic, and systemic inflammatory disease, which is predominantly characterized by an increase of M1 macrophages and the inflammatory mediators in adipose tissue [26, 27].”
BackgroundMirza, A. Z., Althagafi, I. I., & Shamshad, H. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.01.067 · Cited by 563 · cited 1×
“PPARs are members of the nuclear receptor superfamily and have three subtypes, PPARα, PPARβ/δ, and PPARγ, which have the properties of anti-inflammation, anti-TLR4 inflammatory response pathway, and anti-NF-κB [35, 36].”
BackgroundThe Steroid Hormone Biosynthesis Pathway as a Target for Endocrine-Disrupting Chemicals
Sanderson, J. T. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl051 · Cited by 518
Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity
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“Senescent adipocytes recruit macrophages, release a variety of proinflammatory cytokines, and promote inflammation [18].”
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Li, C., Xu, M. M., Wang, K., Adler, A. J., Vella, A. T., & Zhou, B. (2017) · Translational research · doi:10.1016/j.trsl.2017.10.004 · Cited by 376 · cited 1×
“Obesity is a “low-grade chronic inflammatory state” caused by multiple factors [8].”
BackgroundThe Epidemiology of Male Infertility
Winters, B. R., & Walsh, T. J. (2013) · Urologic Clinics of North America · doi:10.1016/j.ucl.2013.08.006 · Cited by 278
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Mancinelli, A. C., Mattioli, S., Twining, C. W., Bosco, A. D., Donoghue, A. M., Arsi, K., Angelucci, E., Chiattelli, D., & Castellini, C. (2022) · Nutrients · doi:10.3390/nu14091969 · Cited by 97
“Thus, the presence of oxidative stressors, such as obesity, sexually transmitted disease, alcohol, and tobacco use, could represent possible factors affecting male infertility [60,61].”
BackgroundSanti, D., Lotti, F., Sparano, C., Rastrelli, G., Isidori, A. M., Pivonello, R., Barbonetti, A., Salonia, A., Minhas, S., Krausz, C. G., et al. (2023) · Andrology · doi:10.1111/andr.13460 · Cited by 73
Pan, X., Yang, L., Wang, S., Liu, Y., Yue, L., & Chen, S. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04784-2 · Cited by 55
“Obesity has been linked to an increase in serum levels of inflammatory factors, which can lead to metabolic disorders and multi-organ damage [23, 24].”
The role of the thyroid in polycystic ovary syndrome
Fan, H., Ren, Q., Sheng, Z., Deng, G., & Li, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1242050 · Cited by 49
Impact of GLP-1 Agonists on Male Reproductive Health—A Narrative Review
Varnum, A. A., Pozzi, E., Deebel, N. A., Evans, A., Eid, N., Sadeghi‐Nejad, H., & Ramasamy, R. (2023) · Medicina · doi:10.3390/medicina60010050 · Cited by 41
“Excess adipose tissue leads to increased peripheral aromatization of testosterone, which results in higher levels of estradiol [15,21].”
Background
Metadata
- Authors
- Yuxin, L., Chen, L., Xiaoxia, L., Yue, L., Junjie, L., Youzhu, L., Huiliang, Z., & Qicai, L.
- Affiliations
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2021-01
- Volume
- 2021
- Issue
- 1
- Pages
- 6612796-6612796
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC7884171
- OpenAlex
- W3126472018
- Cited by
- 51
- References
- 41
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 11
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81871293)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- obesity, inflammation, aromatase, male infertility, adipose tissue, PPARγ, aromatase gene expression, adipogenesis, androgen to estrogen conversion, spermatogenesis, hormonal imbalance
- MeSH terms
- Animals, Aromatase, Humans, Infertility, Male, Inflammation, Male, Models, Biological, Obesity, Biomedical Research
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