Weight gain and inflammation regulate aromatase expression in male adipose tissue, as evidenced by reporter gene activity

Polari, L.; Yatkin, E.; Martínez Chacón, M.G.; Ahotupa, M.; Smeds, A.; Strauss, L.; Zhang, F.; Poutanen, M.; Saarinen, N.; Mäkelä, S.I.

doi:10.1016/j.mce.2015.06.002

Cited by 38Adipokines, Inflammation, and Metabolic DiseasesEstrogen and related hormone effectsCardiovascular Disease and Adiposity

Weight gain and inflammation regulate aromatase expression in male adipose tissue, as evidenced by reporter gene activity

Polari, L., Yatkin, E., Martínez Chacón, M.G., Ahotupa, M., Smeds, A., Strauss, L., Zhang, F., Poutanen, M. +2 more·2015·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2015.06.002

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Abstract

Obesity and white adipose tissue (WAT) inflammation are associated with enhanced aromatization in women, but little is known about the regulation of aromatase (CYP19A1) gene expression in male WAT. We investigated the impact of weight gain and WAT inflammation on the regulation of CYP19A1 in males, by utilizing the hARO-Luc aromatase reporter mouse model containing a >100-kb 5'-region of the human CYP19A1 gene. We show that hARO-Luc reporter activity is enhanced in WAT of mice with increased adiposity and inflammation. Dexamethasone and TNFα, as well as forskolin and phorbol 12-myristate 13-acetate, upregulate hARO-Luc activity, suggesting the involvement of promoters I.4 and I.3/II. Furthermore, we show that diet enriched with antioxidative plant polyphenols attenuates WAT inflammation and hARO-Luc activity in obese males. In conclusion, our data suggest that obesity-associated WAT inflammation leads to increased peripheral CYP19A1 expression in males, and that polyphenol-enriched diet may have the potential to attenuate excessive aromatization in WAT of obese men.

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Chronic inflammation associated with obesity and inflammatory factors (e.g., IL-6 and TNF-α) increase the expression of the Cyp19a1 gene encoding aromatase in testicular tissues.
“Chronic inflammation associated with obesity, and inflammatory factors (e.g., IL-6 and TNF-α) increase the expression of the Cyp19a1 gene encoding the aromatase enzyme in testicular tissues [43,44].”
From Prevention of Diet-Induced Obesity by Phytoecdysteroids 20-Hydroxyecdysone and Calonysterone—Unexpected Modulation of Androgen Balance in Normal and Obese Rats (2026) · cites this paper as [44]

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Authors: Polari, L., Yatkin, E., Martínez Chacón, M. G., Ahotupa, M., Smeds, A., Strauss, L., Zhang, F., Poutanen, M., Saarinen, N., & Mäkelä, S. I.
Affiliations: University of Turku (FI)
Åbo Akademi University (FI)
Corresponding author: Mäkelä, S.I.
ORCID: Polari, L.
Yatkin, E.
Strauss, L.
Zhang, F.
Poutanen, M.
Saarinen, N.
Mäkelä, S.I.
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2015-09
Volume: 412
Pages: 123-130
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2015.06.002
OpenAlex: W585962525
Semantic Scholar: 9f7e4f1d113b689bfa60ea1ce2b763434e12778c
Cited by: 38
References: 45
Citations by year: 2026: 2 · 2025: 4 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 12 · 2019: 3 · 2018: 3 · 2017: 8 · 2016: 2
FWCI: 3.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Åbo Akademi University Research Portal (submittedVersion)
Funders: Turun Yliopisto
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: aromatase, CYP19A1, white adipose tissue, obesity, adipose tissue inflammation, weight gain, aromatization, dexamethasone, TNF-α, forskolin, phorbol ester, plant polyphenols, antioxidant diet, male obesity
MeSH terms: Animals, Antioxidants, Aromatase, Cells, Cultured, Enzyme Induction, Luciferases, Male, Obesity, Plant Extracts, Weight Gain, Transcriptional Activation, Gene Expression, Cytokines, Genes, Reporter, Mice, Adipose Tissue, White, Diet, High-Fat, Polyphenols

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Weight gain and inflammation regulate aromatase expression in male adipose tissue, as evidenced by reporter gene activity

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