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Cited by 13Ginger and Zingiberaceae researchThyroid Disorders and TreatmentsGinseng Biological Effects and Applications

Efficacy of Ginger Supplementation in Relieving Persistent Hypothyroid Symptoms in Patients with Controlled Primary Hypothyroidism: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial

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Ashraf, Hamide, Heydari, Mojtaba, Shams, Mesbah, Zarshenas, Mohammad Mehdi, Tavakoli, Ali, Sayadi, Mehrab·2022·Evidence-Based Complementary and Alternative Medicine
DOI 10.1155/2022/5456855PMC PMC8794674
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Abstract

Primary hypothyroidism is a common disease. Some patients have persistent symptoms despite normal serum thyroid-stimulating hormone (TSH) levels. Ginger is reported to be beneficial in relieving similar symptoms. Our aim was to evaluate the efficacy of ginger supplementation in relieving persistent symptoms in these patients. In this randomized, double-blind, placebo-controlled clinical trial, 60 hypothyroid patients aged 20–60 years with normal serum TSH concentrations were randomly allocated to two equal parallel study groups of ginger (500 mg twice a day) or placebo for 30 days. Hypothyroid symptoms were evaluated as the primary outcome using the Thyroid Symptom Rating Questionnaire (ThySRQ) before and after the intervention. Anthropometric measures and laboratory indices including TSH, triglyceride (TG), total cholesterol (TChol), and fasting blood sugar (FBS) were considered as secondary outcomes. A significant lower mean total ThySRQ score (8.63 ± 5.47 vs. 15.76 ± 6.09, P < 0.001 ) was observed in the ginger group compared to the control group. Ginger led to significant improvements in the mean scores of the weight gain, cold intolerance, constipation, dry skin, appetite, memory loss, concentration disturbance, and feeling giddy or dizzy domains ( P < 0.001 ). However, no significant improvements were observed in hair loss, nail fragility, hearing, hoarseness, speech, and depression or feeling down ( P > 0.05 ). Ginger supplementation also led to a significant decrease in body weight, body mass index, waist circumference, serum TSH, FBS, TG, and TChol levels compared to the placebo. In summary according to preliminary results of this study, ginger supplementation can help relieve persistent hypothyroid symptoms. Also, it may have beneficial effects in terms of weight reduction and regulation of the FBS and lipid profile in hypothyroid patients.

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Authors
Ashraf, H., Heydari, M., Shams, M., Zarshenas, M. M., Tavakoli, A., & Sayadi, M.
Affiliations
  • Shiraz University (IR)
  • Shiraz University of Medical Sciences (IR)
Corresponding author
  • Shams, Mesbah
  • Tavakoli, Ali
ORCID
Venue
Evidence-Based Complementary and Alternative Medicine
Publisher
Wiley
Published
2022-01-20
Volume
2022
Pages
1-10
ISSN
  • 1741-427X (ISSN-L)
  • 1741-4288
DOI
10.1155/2022/5456855
PMC
PMC8794674
OpenAlex
W4205885649
Cited by
13
References
11
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 5
FWCI
2.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Shiraz University of Medical Sciences (97–17708)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginger and Zingiberaceae research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
Keywords
ginger supplementation, primary hypothyroidism, thyroid-stimulating hormone, weight gain, lipid profile, fasting blood glucose, cold sensitivity, complementary therapy

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